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San Francisco Giants vs Boston Red Sox Prediction 06/22/2025 Picks
Pick details
Boston (40-38) vs San Francisco (43-34)
June 22, 2025 at 04:05 PM EDT
The Line: Betting Odds: San Francisco -160 / Boston +135 — Over/Under: +7.5
The Boston Red Sox are visiting the San Francisco Giants on Sunday, June 22nd at the Oracle Parkin the third game of this series, with both teams being tied 1-1 wins. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Boston Red Sox vs San Francisco Giants Prediction. We will examine:
The San Francisco Giants recent form and player performance
The Boston Red Sox recent form and player performance
Recent betting trends and streaks involving the San Francisco Giants
Recent betting trends and streaks involving the Boston Red Sox
Recent betting trends in games played between the Boston Red Sox vs San Francisco Giants
A summary that ties it all together and produces a favorable betting outcome for the Boston Red Sox vs San Francisco Giants game
San Francisco Giants Preview
The San Francisco Giants have a 43-34 record this season and are sitting on the second place of the NL West. They have a 24-14 home record and are 35-40 in over/under. They are coming off a 3-2 home victory over the Red Sox, and are 2-5 in their last 7 games. Under is 4-1-1 in their last 6 games, and are playing the White Sox and the Marlins next.
The Giants have a .231 batting average this season, .312 OBP and .371 Slugging percentage. San Francisco’s pitching staff has a 3.25 ERA and 1.21 WHIP. Heliot Ramos leads the Giants with 81 hits and is the team’s best hitter, with a .282 batting average, while adding a team-high 13 home runs. Wilmer Flores leads the team in RBI with 54.
Robbie Ray (L) is the projected starting pitcher for the Giants, and he has an 8-2 record, 2.68 ERA and 1.12 WHIP. He has been better at home, with a 2.29 ERA across 8 home starts but he has given up 2+ runs in each of his last three starts. Robbie Ray has a record of 2-2 with an ERA of 3.54 and 45 strikeouts in 8 appearances against the Red Sox in his career.
Boston Red Sox Preview
The Boston Red Sox have a 40-38 record this season and are sitting on the 4th place of the AL East. The Red Sox have a 18-21 road record and are 35-42 in over/under. They are coming off a 2-3 road defeat by the Giants and are 8-2 in their last 10 games. They are 8-2 to the under in their last 10 games and are playing the Blue Jays and the Angels next.
The Red Sox have a .248 batting average this season, .322 OBP and .415 slugging percentage. Boston’s pitching staff has a 3.90 ERA and 1.31 WHIP. Jarren Duran leads the Red Sox with 84 hits, adding a team-high 38 RBI, while being the team’s best hitter, with a .257 batting average.
Lucas Giolito (R) is the projected starting pitcher for the Red Sox, and he has a 3-1 record, 4.73 ERA and 1.42 WHIP. He has been excellent on the road, with a 1.93 ERA across four road starts, and he is coming off back-to-back shutout starts across 12 innings pitched against the Mariners and the Rays. Lucas Giolito is 1-1 with an ERA of 3.63 and 19 strikeouts in 3 appearances against the Giants in his career.
Why the San Francisco Giants will win
The Red Sox have lost each of their last six day games against NL West opponents.
The Giants have won 10 of their last 12 day games at Oracle Park following a win.
The Red Sox have failed to cover the run line in four of their last five day games against NL West opponents.
The Red Sox have trailed after 3 innings in each of their last seven road games against National League opponents that held a winning record.
The Red Sox have lost the first inning in each of their last four games as underdogs against National League opponents.
The Red Sox have trailed after 5 innings in five of their last six road games against National League opponents that held a winning record.
Why the Boston Red Sox will win
The Giants have lost each of their last six games as favorites against AL East opponents following a win.
The underdogs have won nine of the Giants’ last 13 games at Oracle Park.
The Giants have failed to cover the run line in each of their last 19 home games against AL East opponents following a win.
The underdogs have covered the run line in each of the Giants’ last 17 games at Oracle Park.
The Giants have trailed after 5 innings in five of their last six day games against American League opponents.
Total Runs Facts
Nine of the Giants’ last 10 games against AL East opponents have gone OVER the total runs line.
Seven of the Red Sox’s last eight games after playing the previous day have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Giants’ last 10 games against AL East opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Red Sox’s last five games against National League opponents.
Matchup/League Facts
The Giants rank 2nd in the league for home runs allowed this season (59).
The Giants rank T3rd in the league for walks this season (278).
The Red Sox rank 1st in the league for doubles this season (145).
The Red Sox rank 28th in the league for strikeouts against this season (722).
Boston Red Sox vs San Francisco Giants Prediction
The Red Sox are 3-2 in their last 5 overall meetings against the Giants, but the Giants are 3-2 in their last 5 meetings in San Francisco. Under is 7-1 in their last 8 meetings.
In this Cleveland GuardiansvsSan Francisco GiantsPrediction, the Giantsare coming as -160 home favorites. Both teams have a similar overall record, but the Giants have been very effective at home, while the Red Sox are below average on the road. San Francisco boasts the best bullpen in the league and the are better against righties, and Ray has been excellent this season, and even better at home. Giolito might be coming off two straight shutouts, but he still sits on a 5.24 expected ERA this season. All things point to another Giants home win in this one.