San Diego Padres vs Seattle Mariners Prediction 8/26/2025 Today’s MLB Picks

The San Diego Padres and Seattle Mariners meet Tuesday in MLB action at T-Mobile Park. Here’s a San Diego Padres vs Seattle Mariners Prediction. This article will include a San Diego Padres vs Seattle Mariners Pick.

San Diego Padres Betting Preview

The San Diego Padres are 74-58 on the year and play the Twins, Orioles, and Rockies next. The San Diego Padres are batting .251 on the season, have a .321 OBP, and a .385 slugging percentage. The San Diego Padres pitching staff has a 3.57 ERA and a 1.19 WHIP. Luis Arraez leads the San Diego Padres with 147 hits and 48 RBI, while Manny Machado and Fernando Tatis Jr. have combined for 276 hits and 132 RBI.

Dylan Cease gets the ball for the San Diego Padres, and he is 6-11 with a 4.71 ERA and 178 strikeouts this season. This will be Cease’s second career game against the Seattle Mariners.

Seattle Mariners Betting Preview

The Seattle Mariners are 71-61 on the year and play the Guardians, Rays, and Braves next. The Seattle Mariners are batting .242 on the season, have a .318 OBP, and a .411 slugging percentage. The Seattle Mariners pitching staff has a 3.96 ERA and a 1.26 WHIP. Julio Rodriguez leads the Seattle Mariners with 140 hits and 73 RBI while J.P. Crawford and Cal Raleigh have combined for 245 hits and 153 RBI.

Luis Castillo gets the ball for the Seattle Mariners, and he is 8-7 with a 3.57 ERA and 127 strikeouts this season. Castillo is 3-3 with a 3.13 ERA and 49 strikeouts in his career against the San Diego Padres.

Why the Seattle Mariners will win

• The Mariners have won 10 of their last 11 home games.
• The Padres have lost seven of their last eight road games against American League opponents.
• The Mariners have covered the run line in seven of their last eight games against NL West opponents that held a winning record.
• The Padres have failed to cover the run line each of their last five night games against American League opponents that held a winning record.
• The Mariners have won the first inning in each of their last three games as favorites against the Padres.
• The Mariners have led after 5 innings in three of their last four night games against the Padres.

Why the San Diego Padres will win

• The Padres have won five of their last six games as road underdogs against AL West opponents following a road loss.
• The Mariners have lost three of their last four games as favorites against National League opponents.
• The Mariners have failed to cover the run line in eight of their last nine home games against National League opponents following a win.
• The Padres have covered the run line in seven of their last eight games as road underdogs against American League opponents following a road loss.
• The Padres have led after 5 innings in four of their last five night games.

Seattle Mariners Player Prop Facts

• J.P. Crawford has recorded a Double in six of his last seven appearances at T-Mobile Park against NL West opponents that held a winning record.
• Cal Raleigh has hit at least one home run in each of the Mariners’ last three games as favorites against the Padres.
• J.P. Crawford has recorded at least one hit in each of his last eight appearances with the Mariners as home favorites against NL West opponents.
• Luis Castillo has recorded five or more strikeouts in each of his last 23 appearances with his team as a home favorite against NL opponents.
• Luis Castillo has recorded a win in four of his last five appearances with the Mariners as favorites against NL West opponents.
• Cal Raleigh ranks 3rd amongst qualified players for Slugging Percentage (.596) this season.

San Diego Padres Player Prop Facts

• Fernando Tatis Jr. has hit a home run in each of the Padres’ last three games against the Mariners at T-Mobile Park.
• Luis Arraez has recorded a Double in each of the Padres’ last three games against AL opponents.
• Luis Arraez has recorded two or more hits in each of the Padres’ last seven games against AL opponents.
• Dylan Cease has recorded nine or more strikeouts in three of his last four appearances with his team as an underdog against AL opponents.
• Dylan Cease has recorded a win in three of his last four appearances against AL opponents that held a winning record.
• Manny Machado ranks T4th in the league in Hits (147) this season.

San Diego Padres vs Seattle Mariners Prediction

We have two capable offenses and two pitchers who can get rocked from time to time. Cease hasn’t been good on the road through 65.1 innings, as he has a 5.65 ERA and .255 allowed batting average. Castillo has allowed 28 hits and 13 runs in his last 19.1 innings. We saw 15 runs between the Mariners and Padres last night and I expect some runs in this spot as well. Give me the over.