San Diego Padres vs Seattle Mariners Prediction 8/25/2025 Today’s MLB Picks

In this article, we will formulate a Padres vs Mariners Prediction for this MLB game on Monday, August 25th at the T-Mobile Park in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Preview

The Seattle Mariners have a 70-61 record this season and are sitting on the second place of the AL West. The Mariners have a 39-26 home record and are 70-55 in over/under. They are coming off a 11-4 home victory over the Athletics, and are 2-6 in their last 8 games. Over is 6-3 in their last 9 games and they are playing the Rays and the Guardians next.

The Mariners have a .241 batting average this season, .317 OBP and .410 Slugging percentage. Seattle’s pitching staff has a 3.95 ERA and 1.26 WHIP. Julio Rodriguez leads the Mariners in hits with 139, while JP Crawford is the team’s best hitter with a .262 batting average. Cal Raleigh leads the team both in RBI with 106, and in home runs with 49.

Bryce Miller (R) is the projected starting pitcher for the Mariners, and he has a 2-5 record, 5.87 ERA and 1.51 WHIP.

San Diego Padres Preview

The San Diego Padres have a 74-57 record this season and are sitting on the second place of the NL West. They have a 31-35 road record, and are 54-73 in over/under. The Padres are coming off a 2-8 home defeat by the Dodgers, which ended their previous five-game winning streak. They are playing the Twins and the Orioles next.

The Padres have a .251 batting average this season, .321 OBP and .383 Slugging percentage. San Diego’s pitching staff has a 3.53 ERA and 1.19 WHIP. Manny Machado leads the Padres with 147 hits and is the team’s best hitter with a .292 batting average. He also leads the team in RBI, with 78, and in home runs, with 21.

JP Sears (R) is the projected starting pitcher for the Padres, and he has an 8-10 record, 4.94 ERA and 1.29 WHIP.

Why the Seattle Mariners will win

• The Mariners have won nine of their last 10 games at T-Mobile Park.
• The Padres have lost each of their last five road games against American League opponents.
• The Mariners have covered the run line in eight of their last nine games against the Padres.
• The Padres have failed to cover the run line in eight of their last nine night games against American League opponents.
• The Padres have trailed after 3 innings in four of their last five night games against opponents that held a winning record.
• The Padres have lost the first inning in four of their last five night games against American League opponents.
• The Padres have trailed after 5 innings in each of their last three road games.

Why the San Diego Padres will win

• The Padres have won each of their last nine games following a home loss.
• The Mariners have lost five of their last six games as favorites after playing the previous day.
• The Mariners have failed to cover the run line in each of their last 10 games as favorites against National League opponents following a win.
• The underdogs have covered the run line in each of the last six games between the Padres and Mariners.
• The Mariners have lost the first inning in three of their last four games as favorites against NL West opponents.
• The Mariners have trailed after 5 innings in each of their last seven games against National League opponents that held a winning record.
• The Mariners have trailed after 3 innings in each of their last five games against National League opponents that held a winning record.

Total Runs Facts

• Each of the Padres’ last eight night games as underdogs have gone UNDER the total runs line.
• Each of the Mariners’ last four games against National League opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Mariners’ last seven games as favorites against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last five games as underdogs against American League opponents.

• The Mariners rank 29th in the league for doubles this season (179).
• The Mariners rank 29th in the league for triples this season (7).
• The Padres rank 1st in the league for opponent batting average this season (.223).
• The Padres rank 1st in the league for hits allowed this season (952).

Padres vs Mariners Prediction

The Mariners are 8-1 in their last 9 head-to-head meetings against the Padres, and are 3-1 their last 4 meetings in Seattle. Under is 6-2-1 in their last 9 meetings.

In this Padres vs Mariners Prediction, the Mariners are coming as -125 home favorites. I don’t trust either pitcher in this matchup, as they both have been shaky at best, and not in the best current form. Miller has not been himself this season, and he has been lit up lately, having given up 19 runs in 18 innings pitched across his last four starts. The Padres have the best bullpen in basketball for come after Sears, and the Mariners are terrible against left-handed pitching, so I like the chances with the road dog in this one. Take the San Diego Padres on the moneyline for plus money.