San Diego Padres vs San Francisco Giants Prediction 6/3/25 MLB Picks

The San Diego Padres are visiting the San Francisco Giants on Tuesday, June 3rd at the Oracle Park in the second game of this series, with the Padres having the 1-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s San Diego Padres vs San Francisco Giants Prediction. We will examine:

The San Francisco Giants recent form and player performance

The San Diego Padres recent form and player performance

Recent betting trends and streaks involving the San Francisco Giants

Recent betting trends and streaks involving the San Diego Padres

Recent betting trends in games played between the San Diego Padres vs San Francisco Giants

A summary that ties it all together and produces a favorable betting outcome for San Diego Padres vs San Francisco Giants game

San Francisco Giants Preview

The San Francisco Giants have a 33-27 record this season and are sitting on the third place of the NL West. They have a 17-10 home record and are 28-32 in over/under. They are coming off a 0-1 home defeat by the Padres, and are 2-5 in their last 7 games. Their last ten game have gone under the total, and are playing the Rockies and the Braves next.

The Giants have a .232 batting average this season, .310 OBP and .371 Slugging percentage. San Francisco’s pitching staff has a 3.05 ERA and 1.19 WHIP.  Heliot Ramos leads the Giants with 66 hits and is the team’s best hitter, with a .295 batting average. Wilmer Flores leads the team in RBI with 47, and in home runs with 10.

Landen Roupp (R) will take the mound for the Giants, and he has a 3-4 record, 3.54 ERA and 1.43 WHIP. He has been better at home, with a 2.30 ERA across three home starts, and he has been in excellent form, having just one earned run across 16 innings pitched in his last three starts. In his previous start against the Padres this season, he gave up 4 runs in 4.1 innings of work.

San Diego Padres Preview

The San Diego Padres have a 34-24 record this season and are sitting on the second place of the NL West. They have a 14-14 road record, and are 24-32 in over/under. The Padres are coming off a 1-0 road victory over the Giants, and are 6-2 in their last 8 games. Under is 3-1 in their last 4 games, and are playing the Dodgers and the Brewers next. 

The Padres have a .248 batting average this season, .314 OBP and .383 Slugging percentage. San Diego’s pitching staff has a 3.54 ERA and 1.21 WHIP.  Manny Machado leads the Padres with 65 hits and team-high .302 batting average. Gavin Sheets leads the team in RBI, with 34, while Fernando Tatis Jr. adds a team-high 13 home runs. 

Ryan Bergert (R) will take the mound for the Padres, and he has been a reliever, which means that we will see a bullpen game from the Padres. Bergert a 1-0 record, 0.00 ERA and 0.25 WHIP. This will be his first career start against the Giants.

Why the San Francisco Giants will win

• The Giants have won each of their last eight games following a home loss.
• The Padres have lost five of their last six games against teams that held a winning record.
• The Padres have failed to cover the run line in each of their last seven road games following an extra innings win.
• The Giants have covered the run line in each of their last six night games against National League opponents following a loss.
• The Giants have led after 3 innings in three of their last four games as home favorites against National League opponents.
• The Padres have trailed after 5 innings in four of their last five road games against National League opponents that held a winning record.

Why the San Diego Padres will win

• The Padres have won each of their last seven games after going to extra innings.
• The Giants have lost seven of their last eight games against teams that held a winning record.
• The Padres have covered the run line in each of their last 11 games as underdogs against the Giants.
• The Giants have failed to cover the run line in each of their last seven games as favorites against the Padres following a loss.
• The Padres have led after 5 innings in each of their last six Tuesday games against National League opponents that held a winning record.
• The Padres have won the first inning in six of their last seven night games against the Giants.
• The Padres have led after 3 innings in four of their last five night games against NL West opponents.

Total Runs Facts

• Each of the Giants’ last 10 games have gone UNDER the total runs line.
• Five of the Padres’ last six games against NL West opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 14 of the Giants’ last 16 night games at Oracle Park.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Padres’ last five night games against NL West opponents.

Matchup/League Facts

• The Giants rank T1st in the league for home runs allowed this season (41).
• The Giants rank 2nd in the league for ERA this season (3.05).
• The Padres rank 1st in the league for strikeouts against this season (401).
• The Padres rank 4th in the league for hits allowed this season (435).

San Diego Padres vs San Francisco Giants Prediction

The Padres have won their last six meetings against the Giants, including all three this season and their last three visits in San Francisco. Under is 4-1 in their last 5 meetings in San Francisco.

In this San Diego Padres vs San Francisco Giants Prediction, the Giants are coming as -150 home favorites. Both teams have almost identical overall records, but the Giants have been strong at home, while the Padres have been mediocre on the road. The Padres have been in better form, but I cannot trust them in a bullpen game on the road. Roupp has been almost unhittable for the Giants lately, and they also have the best bullpen in the league. I expect a bounce-back performance and a win for the San Francisco Giants in this one.