San Diego Padres vs San Francisco Giants Prediction 8/11/2025 Today’s MLB Picks

The San Diego Padres and San Francisco Giants meet Monday in MLB action at Oracle Park. Here’s a San Diego Padres vs San Francisco Giants Prediction. This article will include a San Diego Padres vs San Francisco Giants Pick.

San Diego Padres Betting Preview

The San Diego Padres are 66-52 on the year and play the Dodgers, Giants, and Dodgers next. The San Diego Padres are batting .251 on the season, have a .321 OBP, and a .380 slugging percentage. The San Diego Padres pitching staff has a 3.62 ERA and a 1.22 WHIP. Luis Arraez leads the San Diego Padres with 135 hits and 44 RBI, while Manny Machado and Fernando Tatis Jr. have combined for 250 hits and 118 RBI. 

Yu Darvish gets the ball for the San Diego Padres, and he is 1-3 with a 6.51 ERA and 23 strikeouts this season. Darvish is 2-3 with a 5.89 ERA and 78 strikeouts in his career against the San Francisco Giants.

San Francisco Giants Betting Preview

The San Francisco Giants are 59-59 on the year and play the Rays, Padres, and Brewers next. The San Francisco Giants are batting .233 on the season, have a .311 OBP, and a .376 slugging percentage. The San Francisco Giants pitching staff has a 3.64 ERA and a 1.28 WHIP. Heliot Ramos leads the San Francisco Giants with 123 hits and 51 RBI while Jung Hoo Lee and Willy Adames have combined for 208 hits and 107 RBI.

Logan Webb gets the ball for the San Francisco Giants, and he is 10-8 with a 3.24 ERA and 165 strikeouts this season. Webb is 4-4 with a 2.98 ERA and 78 strikeouts in his career against the San Diego Padres.

Why the San Francisco Giants will win

• The Padres have lost each of their last four games against NL West opponents following a home win.
• The Giants have won each of their last three night games against NL West opponents.
• The Padres have failed to cover the run line in seven of their last eight games against NL West opponents following a win.
• The Giants have covered the run line in three of their last four games following a loss.
• The Padres have trailed after 3 innings in four of their last five night games against NL West opponents.
• The Padres have trailed after 5 innings in six of their last seven road night games.

Why the San Diego Padres will win

• The Giants have lost each of their last seven games at Oracle Park following a loss.
• The Padres have won 10 of their last 12 games after playing the previous day.
• The Giants have failed to cover the run line in each of their last 14 games at Oracle Park following a loss.
• The Padres have covered the run line in 10 of their last 12 road games against the Giants.

San Francisco Giants Player Prop Facts

• Jung Hoo Lee has recorded a Double in six of the Giants’ last seven games against NL opponents that held a winning record.
• Casey Schmitt has hit a home run in two of his last three appearances in night games against NL West teams that held a winning record.
• Dominic Smith has recorded at least one hit in each of his last 11 appearances against NL opponents.

San Diego Padres Player Prop Facts

• Xander Bogaerts has hit a home run in three of the Padres’ last four road games against NL opponents.
• Jake Cronenworth has recorded at least one hit in each of the Padres’ last six road games against NL West opponents.
• Manny Machado has recorded at least one Double in four of the Padres’ last five road games.

San Diego Padres vs San Francisco Giants Prediction

We know what Darvish is capable of when he’s right, but he’s had issues working his way back into form. In 27.2 innings this season, Darvish has allowed 26 hits and 20 runs. Darvish has also walked 11 in those frames, so control has been an issue as well. Webb has not only been solid this season, but he’s been fantastic at Oracle in his career. In 80 career starts in San Francisco, Webb has a 2.78 ERA and 1.12 WHIP. The Giants have been a mess in the second half, but with a clear edge on the mound, I’ll back them in this spot.