Apr 21, 2026; Denver, Colorado, USA; Colorado Rockies and San Diego Padres fans with the 999 challenge hot dog and beer food during the game at Coors Field. Mandatory Credit: Ron Chenoy-Imagn Images
Ron Chenoy-Imagn Images

San Diego Padres vs Colorado Rockies Prediction 4/22/2026 Today’s MLB Picks

Pick details

MATCHUP San Diego Padres Colorado Rockies
Team Records 16-7 9-15
Where Coors Field, Denver, Colorado
When Wednesday, April 22, 2026
Time 08:40 PM EDT
TV MLB.TV

The San Diego Padres and Colorado Rockies meet Wednesday in MLB action at Coors Field. Here’s a San Diego Padres vs. Colorado Rockies Prediction. This article will include a San Diego Padres vs. Colorado Rockies Pick.

San Diego Padres Betting Preview


The San Diego Padres are 16-7 on the year and play the Cubs and Diamondbacks next. The San Diego Padres are batting. 230 on the season, have a .307 OBP, and have a .364 slugging percentage. The San Diego Padres pitching staff has a 3.22 ERA and a 1.19 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 22 hits and 12 RBI, while Ramon Laureano and Xander Bogaerts have combined for 43 hits and 29 RBI.

Walker Buehler gets the ball for the San Diego Padres, and he is 1-1 with a 4.58 ERA and 18 strikeouts this season. Buehler is 7-4 with a 4.48 ERA and 128 strikeouts in his career against the Colorado Rockies.

Colorado Rockies Betting Preview


The Colorado Rockies are 9-15 on the year and play the Reds and Mets next. The Colorado Rockies are batting .238 on the season and have a .304 OBP, and a .380 slugging percentage. The Colorado Rockies pitching staff has a 4.26 ERA and a 1.40 WHIP. Troy Johnston leads the Colorado Rockies with 21 hits and 10 RBI while TJ Rumfield and Hunter Goodman have combined for 40 hits and 19 RBI.

Tomoyuki Sugano gets the ball for the Colorado Rockies, and he is 1-1 with a 3.92 ERA and 15 strikeouts this season. This will be Sugano’s second career game against the San Diego Padres.

Why the Colorado Rockies will win

  • The underdogs have won six of the Rockies’ last nine games at Coors Field.
  • The Padres have lost six of their last eight night games against the Rockies at Coors Field following a road win.
  • The Rockies have covered the run line in each of their last six home games following a loss.
  • The Padres have failed to cover the run line in seven of their last eight night games against the Rockies at Coors Field following a road win.

Why the San Diego Padres will win

  • The Padres have won each of their last 10 games as favorites.
  • The Rockies have lost 12 of their last 13 night games against National League opponents.
  • The Padres have covered the run line in each of their last five games against National League opponents after playing the previous day.
  • The Rockies have failed to cover the run line in 12 of their last 15 night games against NL West opponents.
  • The Padres have led after 5 innings in four of their last five games against National League opponents that held a losing record.

Total Runs Facts

  • Each of the Padres’ last four road games has gone UNDER the total runs line.
  • Five of the Rockies’ last six night games after playing the previous day have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last seven games.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Rockies’ last eight night games.

Colorado Rockies Player Prop Facts

  • Hunter Goodman has hit a home run in three of his last four appearances against the Padres at Coors Field.
  • Tyler Freeman has recorded at least one hit in each of the Rockies’ last nine Wednesday games at Coors Field.

San Diego Padres Player Prop Facts

  • Luis Campusano has hit a home run in two of his last three appearances against the Rockies.
  • Fernando Tatis Jr. has recorded two or more hits in each of the Padres’ last three games as favorites against the Rockies.

Matchup/League Facts

  • The Rockies rank 28th in the league for opponent batting average this season (.266).
  • The Rockies rank 27th in the league for home runs allowed this season (32).
  • The Padres rank 2nd in the league for ERA this season (3.22).
  • The Padres rank T4th in the league for doubles this season (46).

San Diego Padres vs Colorado Rockies Prediction


Sugano has been solid through 20.2 innings, but it’s not enough for me to step in front of the Padres. I keep saying it, but the Padres have some magic to them and they keep winning. Until that stops, I’m going to keep backing the Padres. The sample size is still fairly small, but the Padres are getting it done and oozing with confidence. Give me the Padres to keep things rolling, especially with prices that are more than reasonable.

Randy Chambers's Pick: San Diego Padres