San Diego Padres vs Cincinnati Reds Prediction 06/27/2025 Picks

The San Diego Padres and Cincinnati Reds meet Friday in MLB action at Great American Ball Park. Here’s a San Diego Padres vs Cincinnati Reds Prediction. This article will include a San Diego Padres vs Cincinnati Reds Pick.

San Diego Padres Betting Preview

The San Diego Padres are 44-36 on the year and play the Phillies, Rangers, and Diamondbacks next. The San Diego Padres are batting .248 on the season, have a .316 OBP, and a .379 slugging percentage. The San Diego Padres pitching staff has a 3.59 ERA and a 1.22 WHIP. Manny Machado leads the San Diego Padres with 91 hits and 47 RBI, while Luis Arraez and Fernando Tatis Jr. have combined for 165 hits and 67 RBI. 

Dylan Cease gets the ball for the San Diego Padres, and he is 3-6 with a 4.43 ERA and 109 strikeouts this season. Cease is 1-1 with a 3.00 ERA and 16 strikeouts in his career against the Cincinnati Reds.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 42-39 on the year and play the Red Sox, Phillies, and Marlins next. The Cincinnati Reds are batting .247 on the season, have a .319 OBP, and a .401 slugging percentage. The Cincinnati Reds pitching staff has a 3.85 ERA and a 1.22 WHIP. Elly De La Cruz leads the Cincinnati Reds with 86 hits and 55 RBI while TJ Friedl and Spencer Steer have combined for 151 hits and 57 RBI.

Nick Martinez gets the ball for the Cincinnati Reds, and he is 4-8 with a 4.40 ERA and 63 strikeouts this season. Martinez is 0-3 with a 6.89 ERA and 9 strikeouts in his career against the San Diego Padres.

Why the Cincinnati Reds will win

The Reds have won each of their last nine games at Great American Ball Park against NL West opponents that held a winning record.
The Padres have lost each of their last six night games following a win.
The Padres have failed to cover the run line in each of their last six games following a win.
The Reds have covered the run line in seven of their last eight home games against NL West opponents that held a winning record.

Why the San Diego Padres will win

The Padres have won each of their last seven games as road favorites against the Reds following a win.
The Reds have lost four of their last five night games against National League opponents.
The Reds have failed to cover the run line in each of their last eight home games against the Padres following a home loss.
The Padres have covered the run line in each of their last seven road games against NL Central opponents.
The Reds have trailed after 5 innings in three of their last four night games against opponents that held a winning record.
The Padres have led after 3 innings in five of their last six night games against National League opponents that held a winning record.

Cincinnati Reds Player Prop Facts

Spencer Steer has hit a home run in two of his last three appearances at Great American Ball Park against NL West opponents that held a winning record.
Elly De La Cruz has recorded a Double in three of the Reds’ last four games against the Padres.
Austin Hays has recorded at least one hit in each of his last eight home appearances.

San Diego Padres Player Prop Facts

Xander Bogaerts has recorded a Double in four of the Padres’ last five games against opponents that held a winning record.
Gavin Sheets has hit a home run in each of his two previous appearances with his team as a favorite against the Reds.
Dylan Cease has recorded seven or more strikeouts in four of his last five appearances against NL opponents.
Gavin Sheets has recorded at least one hit in each of the Padres’ last nine games against NL opponents that held a winning record.
Dylan Cease ranks 10th in the league for total Strikeouts (109) this season.

San Diego Padres vs Cincinnati Reds Prediction

I’m looking at the over in this spot. Cease has been hittable this season, and he’s at his worst on the road, where he has a 6.26 ERA and .261 allowed batting average. Martinez has been terrible this month, allowing 28 hits and 17 runs in his last 21.1 innings. Martinez allowed three homers in two of his last four starts. The Padres are one of the more talented offenses in baseball, and the Reds are playing their best ball of the season. I expect some fireworks in this contest. Give me the over.

Randy Chambers's Pick: Over 9