San Diego Padres vs Arizona Diamondbacks Prediction 6/13/25 MLB Picks

In this article, we will formulate a Padres vs Diamondbacks prediction for this MLB game on Friday, June 13, at Chase Field in Phoenix, Arizona. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Betting Preview

The San Diego Padres (38-29, 17-17 Away) split the series with the San Francisco Giants, beat the Milwaukee Brewers, and lost to the Los Angeles Dodgers. In the rubber match on Wednesday, the Padres lost 5-2. Randy Vasquez pitched for 4.2 innings in a no-decision, allowing one run on two hits with four strikeouts and one walk. Adrian Morejon took the loss. 

This year, the Padres average 4.16 runs per game (19th in the MLB) on a .247/.315/.375 triple-slash. When it comes to pitching, the Padres’ staff has a 3.44 ERA (6th) and 1.21 WHIP (11th). Gavin Sheets leads the Padres with a .251 batting average, 11 home runs, and 39 RBI this season.

The projected starting pitcher for the Padres is Stephen Kolek, who is 3-1 in seven starts this season, with a 3.00 ERA and 1.24 WHIP in 42.0 innings.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks (34-34, 18-17 Home) are playing in hot and cold form lately. They swept the Atlanta Braves, were swept by the Cincinnati Reds, and then swept the Seattle Mariners. In the most recent 5-2 victory, Eugenio Suarez hit a grand slam to lead his offense with four RBI, while Eduardo Rodrigues got the win after allowing two runs on six hits with five strikeouts and one walk across 6.1 innings of work. 

This season, the Diamondbacks average 5.09 runs per game (4th in the MLB) on a .255/.333/.449 triple-slash. When it comes to pitching, the Diamondbacks’ staff has a 4.77 ERA (25th) and 1.34 WHIP (21st). Eugenio Suarez leads the Diamondbacks with a .233 batting average, 19 home runs, and 52 RBI this season.

Ryne Nelson will take the mound for the Diamondbacks on Friday. The 27-year-old right-hander has a 2-2 record in four starts this year with a 4.60 ERA and 1.11 WHIP in 45.0 innings.

Why the Padres will beat the Diamondbacks

• The Diamondbacks have lost seven of their last eight games as favorites against National League opponents.
• The Padres have won each of their last six night games against National League opponents following a loss.
• The Padres have covered the run line in each of their last seven games as road underdogs.
• The Diamondbacks have failed to cover the run line in 11 of their last 12 night games at Chase Field following a home win.

Total Runs Facts

• Eight of the Padres’ last nine games as road underdogs have gone UNDER the total runs line.
• Four of the Diamondbacks’ last five home games against National League opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last six games as road underdogs against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Diamondbacks’ last six games at Chase Field.

Matchup/League Facts

• The Diamondbacks rank 3rd in the league for triples this season (14).
• The Diamondbacks rank 3rd in the league for slugging percentage this season (.449).
• The Padres rank T26th in the league for home runs this season (57).
• The Padres rank 5th in the league for opponent batting average this season (.226).

Padres vs Diamondbacks Prediction

The teams have traded victories in the past couple of years, each recording five in the previous ten H2H encounters. Stephen Kolek has been excellent in his previous two starts and allowed zero runs in 11.1 innings. Ryne Nelson had a fantastic May but struggled in his first start in June, allowing seven runs in 3.0 innings in a loss to the Reds. Although I don’t think he will struggle that much in this one, I do expect the Padres to get to him and score 3+ runs off him in the opening five innings. Go with San Diego.