San Diego Padres vs Arizona Diamondbacks Prediction 08/05/2025 Today’s MLB Picks

In this article, we will formulate a Padres vs Diamondbacks prediction for this MLB game on Tuesday, August 5, at Chase Field in Phoenix, Arizona. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Betting Preview

The San Diego Padres (62-51, 26-32 Away) have swept the New York Mets and beat the St. Louis Cardinals before losing the opening game of the series against the Diamondbacks on Monday. Jackson Merrill and Jake Cronenworth had an RBI apiece in a 6-2 defeat, while JP Sears took the loss in his first start for San Diego following his move from the Athletics. He allowed five runs on ten hits with four strikeouts and one walk in 5.0 innings.

This year, the Padres average 4.12 runs per game (24th in the MLB) on a .251/.319/.381 triple-slash. When it comes to pitching, the Padres’ staff has a 3.56 ERA (3rd) and 1.21 WHIP (3rd). Manny Machado leads the Padres with a .299 batting average, 20 home runs, and 72 RBI this season.

The projected starting pitcher for the Padres is Yu Darvish, who is 1-3 in five starts this season, with a 6.46 ERA and 1.35 WHIP in 23.2 innings.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks (54-59, 27-28 Home) lost a series to the Pittsburgh Pirates and were swept by the Detroit Tigers, but returned to winning ways against the Athletics. Arizona is now on a three-game winning streak after defeating the Padres 6-2 in Game 1 of the current series last night. Corbin Carroll and Lourdes Gurriel Jr. led the offense with two RBI apiece, while Brandon Pfaadt got the win after allowing two runs on five hits with four strikeouts and three walks in 5.2 innings.

This season, the Diamondbacks average 4.84 runs per game (6th in the MLB) on a .249/.324/.435 triple-slash. When it comes to pitching, the Diamondbacks’ staff has a 4.57 ERA (25th) and 1.33 WHIP (24th). Geraldo Perdomo leads the Diamondbacks with a .278 batting average, 11 home runs, and 75 RBI this season.

Ryne Nelson will take the mound for the Diamondbacks on Tuesday. The 27-year-old right-hander has a 6-3 record in 13 starts this year with a 3.20 ERA and 1.02 WHIP in 95.2 innings.

Total Runs Facts

• Five of the Diamondbacks’ last six night games after playing the previous day have gone UNDER the total runs line.
• Each of the Padres’ last three road games against NL West opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Diamondbacks’ last seven night games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Padres’ last five night games at Chase Field.

Matchup/League Facts

• The Diamondbacks rank 5th in the league for doubles this season (197).
• The Diamondbacks rank 5th in the league for RBIs this season (536).
• The Padres rank 2nd in the league for opponent batting average this season (.228).
• The Padres rank 3rd in the league for strikeouts against this season (791).

Padres vs Diamondbacks Prediction

The Diamondbacks won six of the previous ten H2H encounters, while this season, Arizona was better in five of eight duels. Only one of Arizona’s last ten games went Over, which is one of the reasons why I am going with Under in this game. Ryne Nelson had a very strong last month, posting a 2.22 ERA in July, while he allowed more than two runs just once in his previous nine starts. Yu Darvish, on the other hand, is still working on his form after coming from a lengthy injury. Following a couple of poor starts, Darvish secured his first win of the season against the Mets, registering a shutout in 7.0 innings along the way. Go with Under.