Pittsburgh Pirates vs San Diego Padres Prediction 6/1/25 MLB Picks

In this article, we will formulate a Pirates vs Padres prediction for this MLB game on Sunday, June 1, at PETCO Park in San Diego, California. Let’s take a look at the prediction for this MLB matchup.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates (22-37, 9-21 Away) are on a three-series winning streak after beating the Reds, Brewers, and Diamondbacks. They did lose Game 1 of the current series against the Padres, but responded with a 5-0 win on Saturday. In that victory, Bryan Reynolds led the offense with two RBI, while Bailey Falter got the win after allowing no runs on two hits with one strikeout and one walk across 6.1 innings of work.

This year, the Pirates average 3.22 runs per game (29th in the MLB) on a .228/.306/.338 triple-slash. When it comes to pitching, the Pirates’ staff has a 3.92 ERA (16th) and 1.24 WHIP (14th). Bryan Reynolds leads the Pirates with a .327 batting average, seven home runs, and 34 RBI this season.

The projected starting pitcher for the Pirates is Andrew Heaney, who is 4-3 in 11 starts this season, with a 3.32 ERA and 1.30 WHIP in 62.1 innings.

San Diego Padres Betting Preview

The San Diego Padres (32-24, 19-10 Home) were swept by the Mariners and Blue Jays, but bounced back with series wins over the Braves and Marlins. The Padres opened the current series against Pittsburgh with a 3-2 win, but lost Game 2, failing to score a single run in the process. Dylan Cease took the loss after allowing three runs on seven hits with six strikeouts and one walk in 4.2 innings.

This season, the Padres average 4.21 runs per game (16th in the MLB) on a .249/.315/.384 triple-slash. When it comes to pitching, the Padres’ staff has a 3.60 ERA (8th) and 1.21 WHIP (11th). Gavin Sheets leads the Padres with a .269 batting average, 11 home runs, and 34 RBI this season.

Randy Vasquez will take the mound for the Padres on Sunday. The 26-year-old right-hander has a 3-4 record in 11 starts this year with a 3.58 ERA and 1.39 WHIP in 55.1 innings.

Why the Padres will beat the Pirates

• The Pirates have lost each of their last seven day games against NL West opponents that held a winning record.
• The Padres have won each of their last seven games against National League opponents following a loss.
• The Pirates have failed to cover the run line in nine of their last 10 day games against teams that held a winning record.
• The Padres have covered the run line in six of their last seven day games against NL Central opponents following a home loss.
• The Padres have led after 5 innings in seven of their last nine day games against the Pirates.

Total Runs Facts

• Each of the Padres’ last four home games against NL Central opponents have gone UNDER the total runs line.
• Eight of the Pirates’ last 10 day games against National League opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Padres’ last six Sunday day games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in three of the Pirates’ last four games at Petco Park.

Matchup/League Facts

• The Padres rank 6th in the league for opponent batting average this season (.228).
• The Padres rank T24th in the league for home runs this season (52).
• The Pirates rank 29th in the league for home runs this season (41).
• The Pirates rank 29th in the league for RBIs this season (184).

Pirates vs Padres Prediction

The Padres won nine of the previous ten H2H encounters, and that Pittsburgh’s lone win came last night. I am backing the Padres to get back in the saddle with a win on Sunday. Although I respect Andrew Heaney and his numbers this season, he did have a weaker month (May) than Randy Vasquez. It’s not going to be easy for the Padres, but I am going with them here. I am not impressed with the Padres’ batting average against southpaws (.233 BA in 529 at-bats), but I am backing them to get this one.