Jul 27, 2025; Bronx, New York, USA; Philadelphia Phillies first baseman Otto Kemp (4) hits his second home run of the game during the fifth inning against the New York Yankees at Yankee Stadium. Mandatory Credit: John Jones-Imagn Images

Philadelphia Phillies vs Chicago White Sox Prediction 07/28/2025 Picks

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Philadelphia (60-45) vs Chicago (38-68)

July 28, 2025 at 07:40 PM EDT

The Line: Betting Odds: Chicago +1.5 — Over/Under: +8.5

(Get latest betting odds)

The Philadelphia Phillies and Chicago White Sox meet Monday in MLB action at Rate Field. Here’s a Philadelphia Phillies vs Chicago White Sox Prediction. This article will include a Philadelphia Phillies vs Chicago White Sox Pick.

Philadelphia Phillies Betting Preview

The Philadelphia Phillies are 60-45 on the year and play the Tigers, Orioles, and Rangers next. The Philadelphia Phillies are batting .255 on the season, have a .328 OBP, and a .413 slugging percentage. The Philadelphia Phillies pitching staff has a 3.73 ERA and a 1.25 WHIP. Trea Turner leads the Philadelphia Phillies with 125 hits and 44 RBI, while Nick Castellanos and Kyle Schwarber have combined for 206 hits and 141 RBI. 

Cristopher Sanchez gets the ball for the Philadelphia Phillies, and he is 9-2 with a 2.40 ERA and 134 strikeouts this season. This will be Sanchez’s first career game against the Chicago White Sox.

Chicago White Sox Betting Preview

The Chicago White Sox are 38-68 on the year and play the Angels, Mariners, and Guardians next. The Chicago White Sox are batting .227 on the season, have a .299 OBP, and a .360 slugging percentage. The Chicago White Sox pitching staff has a 4.10 ERA and a 1.38 WHIP. Miguel Vargas leads the Chicago White Sox with 85 hits and 41 RBI while Lenyn Sosa and Chase Meidroth have combined for 161 hits and 52 RBI.

Davis Martin gets the ball for the Chicago White Sox, and he is 2-8 with a 3.89 ERA and 56 strikeouts this season. This will be Martin’s first career game against the Philadelphia Phillies.

Why the Chicago White Sox will win

  • The White Sox have won three of their last four games as underdogs against National League opponents following a home loss.
  • The Phillies have lost nine of their last 15 games as road favorites after playing the previous day.
  • The White Sox have covered the run line in each of their last six games as underdogs following a loss.
  • The Phillies have failed to cover the run line in each of their last five Monday games against American League opponents.

Why the Philadelphia Phillies will win

  • The Phillies have won 10 of their last 11 night games against American League opponents that held a losing record.
  • The White Sox have lost each of their last five night games against NL East opponents that held a winning record.
  • The Phillies have covered the run line in eight of their last nine games as road favorites against AL Central opponents following a road loss.
  • The White Sox have failed to cover the run line in seven of their last eight night games against National League opponents following a home loss.
  • The White Sox have trailed after 5 innings in each of their last three home games against NL East opponents that held a winning record.
  • The White Sox have trailed after 3 innings in six of their last eight night games against NL East opponents that held a winning record.

Chicago White Sox Player Prop Facts

  • Mike Tauchman has hit a home run in three of the White Sox’s last four games as underdogs against NL opponents.
  • Luis Robert has recorded at least one hit in each of his last seven appearances in night games.
  • Michael A. Taylor has recorded a Double in four of his last five appearances against NL opponents.

Philadelphia Phillies Player Prop Facts

  • Kyle Schwarber has hit a home run in four of the Phillies’ last five night games against opponents that held a losing record.
  • J.T. Realmuto has recorded at least one hit in each of his last eight road appearances.
  • Brandon Marsh has recorded a Double in three of his last four appearances against AL Central opponents.
  • Kyle Schwarber ranks T4th in the league in Home Runs (36) this season.

Philadelphia Phillies vs Chicago White Sox Prediction

The White Sox started the second half off hot, but they’re coming off two ugly losses and are remaining us they’re one of the worst teams in baseball history, 30 games below a .500 record. As I’ve said many times, I’m not in the business of backing the White Sox. The Phillies are comfortably the better team and Sanchez is an all-star caliber pitcher, wallowing 22 hits and four runs in his last 30.1 innings. Sanchez has allowed six runs in his last 44.1 innings. In 66.1 road innings, Sanchez has a 2.17 ERA. Give me the Phillies and the RL for max betting value.

Randy Chambers's Pick: Philadelphia Phillies -1.5

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