Philadelphia Phillies vs Arizona Diamondbacks Prediction 9/19/2025 Today’s MLB Picks

In this article, we will formulate a Phillies vs Diamondbacks Prediction for this MLB game on Friday, September 19th at the Chase Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 77-76 record this season and are sitting on the third place of the NL West. The Diamondbacks have a 40-35 home record and are 73-71 in over/under They are coming off a 1-5 home defeat by the Giants, which ended their four-game winning streak. They are playing the Padres and the Dodgers next.

The Diamondbacks have a .251 batting average this season, .324 OBP and .434 slugging percentage. Arizona’s pitching staff has a 4.44 ERA and 1.31 WHIP. Geraldo Perdomo leads the Diamondbacks with 162 hits, adding a team-high 97 RBI. He Is also the team’s best hitter with a .289 batting average, while Corbin Carroll leads the team in home runs with 30.

Ryne Nelson (R) is the projected starting pitcher for the Diamondbacks, and he has a 7-3 record, 3.34 ERA and 1.06 WHIP.

Philadelphia Phillies Preview

The Philadelphia Phillies have a 91-62 record this season and are sitting on the first place of the NL East. They have a 40-38 road record, and are 68-75 in over/under. They are coming off a 3-2 home victory over the Braves, and have three consecutive wins. Under is 3-1 in their last 4 games and are playing the Twins and the Marlins next.

The Phillies have a .259 batting average this season, .330 OBP and .431 Slugging percentage. Philly’s pitching staff has a 3.86 ERA and 1.24 WHIP. Trea Turner leads the Phillies with 179 hits and he is the team’s best hitter, with a .305 batting average. Kyle Schwarber leads the team with 128 RBI and a team-high 53 home runs.

Taijuan Walker (R) is the projected starting pitcher for the Phillies, and he has a 5-8 record, 4.17 ERA and 1.39 WHIP.

Philadelphia Phillies @ Arizona Diamondbacks Betting Trends: September 19, 2025

• Probable Starting Pitcher: Ryne Nelson      Record this season: 7-3      ERA: 3.34
• Home Record: 5-1
• Last 5 against Phillies: 0-1

Why the Arizona Diamondbacks will win

• The Phillies have lost each of their last nine games as underdogs against NL West opponents following a road loss.
• The Diamondbacks have won each of their last five games after going to extra innings.
• The Phillies have failed to cover the run line in eight of their last nine games as underdogs against NL West opponents following a road loss.
• The Diamondbacks have covered the run line each of their last six Friday games against NL East opponents that held a winning record.
• The Phillies have trailed after 3 innings in 10 of their last 12 games as road underdogs.
• The Phillies have trailed after 5 innings in each of their last nine games as road underdogs against NL West opponents.
• The Diamondbacks have won the first inning in each of their last nine home games against National League opponents that held a winning record.

• Probable Starting Pitcher: Taijuan Walker      Record this season: 5-8      ERA: 4.17
• Road Record: 2-4
• Last 5 against Diamondbacks: 0-1

Why the Philadelphia Phillies will win

• The Phillies have won each of their last four games as underdogs following a loss.
• The Diamondbacks have lost five of their last six games as favorites against NL East opponents.
• The Phillies have covered the run line in 11 of their last 12 games as underdogs following a loss.
• The Diamondbacks have failed to cover the run line in seven of their last eight games as favorites against National League opponents.
• The Diamondbacks have trailed after 3 innings in five of their last six night games against NL East opponents that held a winning record.
• The Phillies have won the first inning in three of their last four games against the Diamondbacks.

Total Runs Facts

• Eight of the Phillies’ last nine games have gone OVER the total runs line.
• Each of the Diamondbacks’ last four games against NL East opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 13 of the Diamondbacks’ last 14 home games against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Phillies’ last eight night games against NL West opponents.

Arizona Diamondbacks Player Prop Facts

• Corbin Carroll has hit at least one home run in six of the Diamondbacks’ last eight home games against NL East opponents that held a winning record.
• Ryne Nelson has recorded six or more strikeouts in five of his last six appearances in night games against teams that held a winning record.
• Corbin Carroll has recorded at least one hit in each of the Diamondbacks’ last 18 games as favorites.
• Lourdes Gurriel Jr. has recorded a Double in four of the Diamondbacks’ last five night games against NL East opponents that held a winning record.
• Geraldo Perdomo ranks 5th amongst qualified players for On Base Percentage (.391) this season.

Philadelphia Phillies Player Prop Facts

• J.T. Realmuto has hit a home run in each of his last two appearances with the Phillies as underdogs against the Diamondbacks.
• Alec Bohm has recorded a Double in three of the Phillies’ last four road games against the Diamondbacks.
• Trea Turner has recorded at least one hit in each of his last 15 road appearances.
• Kyle Schwarber ranks 2nd in the league in Home Runs (53) this season.

Matchup/League Facts

• The Diamondbacks rank 1st in the league for triples this season (37).
• The Diamondbacks rank 3rd in the league for RBIs this season (737).
• The Phillies rank 2nd in the league for walks allowed this season (415).
• The Phillies rank 3rd in the league for hits this season (1350).

Phillies vs Diamondbacks Prediction

The Diamondbacks are 4-2 in their last 6 head-to-head meetings against the Phillies, and have won their last three meetings in Arizona.

In this Phillies vs Diamondbacks Prediction, the Diamondbacks are coming as -125 home favorites. The Phillies are the better team, but recently clinched their playoff spot, while the Dbacks are still fighting for a Wild Card spot in the NL. Nelson has been a better pitching option than Walker, and he has been excellent at home, with a 2.51 ERA. He has one earned run or less in three of his last four starts, while on the flip side, Walker has been struggling for the Phillies lately, with an atrocious 7.20 ERA across his last 5 starts. The Dbacks need this win and they have the pitching advantage, so take them to win this one at home.