Padres vs White Sox Prediction 9/19/2025 Today’s MLB Picks

In this article we will formulate a Padres vs White Sox prediction for this MLB game on Friday, September 19th at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

San Diego Padres Betting Preview

The San Diego Padres are 83-70 this year after they lost two out of three against the Mets by scores of 3-8, 7-4, and 1-6. In their game three loss, San Diego tied the game at one in the third inning, but allowed the last five runs for the loss. The Padres recorded six hits in the game and they were led by Arraez, who went 1-3 with one RBI in the loss. San Diego started Vasquez, who allowed four hits and four earned runs over 2.1 innings for the loss, while Peralta and Marinaccio each allowed one earned run in relief. 

Prior to that series, the Padres won three out of four against the Rockies, but lost two out of three against the Reds before that. San Diego has won three of their last five games and they are second in the NL West standings. The San Diego pitching staff has a 3.69 ERA with a 1.20 WHIP and a .226 opponent batting average, while their offense has scored 652 runs with a .252 batting average and a .321 on base percentage this season. Manny Machado has led San Diego with 26 home runs and 92 RBIs, while Fernando Tatis has added 22 home runs and 65 RBIs this year. The projected starting pitcher for San Diego is Dylan Cease, who is 8-11 with a 4.59 ERA and a 1.32 WHIP over 157.0 innings pitched this year. 

Chicago White Sox Betting Preview

The Chicago White Sox are 57-96 this season after they lost all three against Baltimore by scores of 1-4, 7-8, and 1-3. In their game three loss, Chicago cut the deficit to 3-1 in the fourth inning, but couldn’t find anymore offense in the defeat. The White Sox recorded five hits and they committed one error in the game, while they were led by Tauchman, who went 1-3 with one home run and one RBI in the loss. Chicago started Perez, who allowed five hits and three earned runs over 3.2 innings for the loss, while five other pitchers closed out the last 5.1 innings. 

Prior to that series, the White Sox lost all three against the Guardians, but did win two out of three against the Rays before that. Chicago has lost six games in a row and they are last in the AL Central standings. The Chicago pitching staff has a 4.23 ERA with a 1.36 WHIP and a .247 opponent batting average, while the offense has scored 609 runs with a .233 batting average and a .302 on base percentage this season. Lenyn Sosa has led Chicago with 20 home runs and 70 RBIs, while Andrew Benintendi has added 20 home runs and 62 RBIs this year. The projected starting pitcher for Chicago is Davis Martin, who is 6-10 with a 4.01 ERA and a 1.28 WHIP over 132.1 innings pitched this season.

Why the Padres will beat the White Sox 

The White Sox have lost 16 of their last 17 night games against NL West opponents that held a winning record.
The Padres have won nine of their last 10 night games against AL Central opponents following a road loss.
The White Sox have failed to cover the run line in seven of their last eight night games following a loss.
The Padres have covered the run line in each of their last four games as road favorites after playing the previous day.
The Padres have won the first inning in three of their last four night games against the White Sox at Rate Field.
The White Sox have trailed after 5 innings in four of their last five home games against opponents that held a winning record.

Total Runs Facts

Six of the White Sox’s last seven games have gone UNDER the total runs line.
Six of the Padres’ last seven games as favorites against the White Sox have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last seven games at Rate Field.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last five games against AL Central opponents.

Chicago White Sox Player Prop Facts

Luis Robert has recorded at least one hit in each of the White Sox’s last six games against NL opponents.
Andrew Benintendi has hit a home run in two of his last three appearances at Rate Field.

San Diego Padres Player Prop Facts

Luis Arraez has recorded at least one hit in each of his last 18 road appearances against AL Central opponents.
Dylan Cease has recorded a win in each of his last three appearances against AL Central opponents.
Jackson Merrill has hit a home run in three of the Padres’ last four games as favorites.
Jake Cronenworth has recorded a Double in three of the Padres’ last four road games against AL opponents. 

Padres vs White Sox Prediction 

San Diego enters this series needing a sweep to stay in the NL West race with the Dodgers, as they are a few games back already. The Padres are 36-42 on the road this year, while the White Sox are 32-46 at home. Chicago has dropped six games in a row and they are starting Martin, who has allowed three earned runs or fewer in five straight starts. SD is going with Cease, who has allowed two earned runs or fewer in three straight starts, but doesn’t go very deep into games. I will take the Padres by at least two runs here, but they aren’t the most trustworthy option out there.