Oakland Athletics vs St. Louis Cardinals Prediction 9/3/2025 Today’s MLB Picks

The Athletics and the St. Louis Cardinals meet Wednesday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Athletics vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Athletics will send out Jeffrey Springs for the start here and Springs is 10-9 with a 4.17 ERA and 122 strikeouts this season. In his career, Springs is 0-1 with a 3.27 ERA and 8 strikeouts against the Cardinals. Matthew Liberatore will get the nod for the Cardinals here and is 6-11 with a 4.32 ERA and 102 strikeouts this season. This will be Liberatore’s second career start against the Athletics.

Athletics Recap

The Athletics come into this game looking to rebound from a 2-1 loss at the hands of the Cardinals to sit at 64-76 after Tuesday’s matchup. After this series, the Athletics will head on the road for a series against the Los Angeles Angels.

Athletics Drop 4 Of Their Last 5

Jacob Wilson has 129 hits, 20 doubles and a .315 batting average while Tyler Soderstrom has 136 hits with 28 doubles, 23 home runs and 81 RBIs this season. Brent Rooker has 146 hits with 35 doubles, 27 home runs and 80 RBIs but also has 132 strikeouts this season while Nick Kurtz has a team-high 27 home runs and 71 RBIs with 24 doubles. Shea Langeliers has 106 hits with 29 home runs and 65 RBIs while Lawrence Butler’s also chipped in 17 stolen bases and 29 doubles as part of his 115 hits as well as 18 home runs and 54 RBIs while also owning a team-high 157 strikeouts this season.

Why the Athletics will win

• The Athletics have won each of their last six games as road underdogs following a loss.
• The Cardinals have lost each of their last eight Wednesday games as favorites.
• The Cardinals have failed to cover the run line in each of their last 12 games as favorites following a home win.
• The Athletics have covered the run line in each of their last eight road games following a loss.

Athletics Player Prop Facts

• Zack Gelof has recorded at least one Double in five of his last six road appearances against opponents that held a losing record.
• Shea Langeliers has hit a home run in three of his last four appearances against opponents that held a losing record.
• JJ Bleday has recorded at least one hit in each of the Athletics’ last eight night games against NL Central opponents that held a losing record.
• Jacob Wilson ranks 2nd amongst qualified players for Batting Average (.315) this season.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to add on to their win over the A’s from Tuesday’s matchup to improve to 69-71 this season. After this series, the Cardinals will take on the San Francisco Giants in a series at home.

Cardinals Win 4 Of Their Last 6

Brendan Donovan has a team-high 118 hits along with 25 doubles, 9 home runs and 45 RBIs while Lars Nootbaar has 106 hits with 13 home runs, 44 RBIs, 22 doubles and 4 stolen bases. Nolan Arenado also has 85 hits with 15 doubles, 10 home runs and 43 RBIs of his own and Victor Scott II has 79 hits with 14 doubles, a triple, 35 RBIs and a team-high 31 stolen bases. Willson Contreras has also chipped in 117 hits with 30 doubles, 20 home runs and 74 RBIs of his own as well this season. Masyn Winn’s added 121 hits with 27 doubles, 9 home runs and 51 RBIs and Alec Burleson’s added 123 hits with 21 doubles, 16 home runs and 60 RBIs.

Why the St. Louis Cardinals will win

• The Athletics have lost four of their last five games.
• The Cardinals have won each of their last three night games after playing the previous day.
• The Athletics have failed to cover the run line in four of their last five games.
• The Cardinals have covered the run line in four of their last five games as favorites against American League opponents.

St. Louis Cardinals Player Prop Facts

• Lars Nootbaar has recorded a Double in four of the Cardinals’ last five night games against AL West opponents that held a losing record.
• Lars Nootbaar has recorded at least one hit in each of the Cardinals’ last eight home games against AL West opponents.
• Alec Burleson has hit a home run in two of his last three appearances with the Cardinals as favorites against AL opponents.

Total Runs Facts

• Nine of the Cardinals’ last 10 games as favorites against AL West opponents have gone OVER the total runs line.
• Six of the Athletics’ last seven games as underdogs have gone OVER the total runs line.

Athletics vs. St. Louis Cardinals Prediction

I’m on the Athletics in this one. I still am not sold on the Cardinals in this matchup, and I’m not sold on Matthew Liberatore here as the Athletics have hit lefties fairly well as of late and Jeffrey Springs has been better when you take him on the road this season. All in all, I think the value is on the Athletics here. Give me the A’s.