Oakland Athletics vs Los Angeles Angels Prediction 9/6/2025 Today’s MLB Picks

In this article, we will formulate an Athletics vs Angels Prediction for this MLB game on Saturday, September 6th at the Angel Stadium in the second game of this series, with the Athletics having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Angels Preview

The Los Angeles Angels have a 66-75 record this season and are sitting on the 4th place of the AL West. The Angels have a 34-36 home record and 76-62 in over/under They are coming off a 4-10 home defeat by the A’s, and have back-to-back losses. Under is 6-2 in their last 8 games and are playing the Mariners and the Twins next.

The Angels have a .227 batting average this season, .302 OBP and .399 Slugging percentage. LA’s pitching staff has a 4.74 ERA and 1.43 WHIP. Zach Neto leads the Angels with 125 hits, while Nolan Schanuel is the team’s best hitter with a .266 batting average. Taylor Ward leads the team with 95 RBI, while Jo Adell adds a team-high 33 home runs.

Yusei Kikuchi (L) is the projected starting pitcher for the Angels, and he has a 6-10 record, 3.83 ERA and 1.44 WHIP.

Athletics Preview

The Athletics have a 65-77 record this season and are sitting on the last place of the AL West. The Athletics have a 36-37 road record and are 72-64 in over/under. They are coming off a 10-4 road victory over the Angels, which ended their two-game losing streak. Over is 4-2 in their last 6 games and are playing the Red Sox and the Reds next.

The Athletics have a .254 batting average this season, .320 OBP and .433 Slugging percentage. Athletics’ pitching staff has a 4.81 ERA and 1.36 WHIP. Brent Rooker leads the Athletics with 149 hits, while Jacob Wilson is the team’s best hitter with a .314 batting average. Tyler Soderstrom adds a team-high 81 RBI, while Shea Langeliers adds a team-high 29 home runs. 

J.T. Ginn (R) is the projected starter for the Athletics, and he has a 2-6 record, 5.17 ERA, and 1.36 WHIP.

Why the Los Angeles Angels will win

• The Angels have won each of their last six games against AL West opponents following a home loss.
• The Athletics have lost each of their last four games against AL West opponents following a win.
• The Angels have covered the run line in each of their last six games against AL West opponents following a home loss.
• The Athletics have failed to cover the run line in four of their last five games against AL West opponents.
• The Athletics have trailed after 5 innings in four of their last five games against AL West opponents.
• The Athletics have trailed after 3 innings in three of their last four games as underdogs against AL West opponents.
• The Angels have won the first inning in four of their last five games as home favorites against AL West opponents.

Why the Athletics will win

• The underdogs have won each of the Athletics’ last four games.
• The Angels have lost five of their last six games as favorites against AL West opponents.
• The Athletics have covered the run line in each of their last 12 Saturday games as road underdogs against American League opponents.
• The Angels have failed to cover the run line in eight of their last nine night games against American League opponents that held a losing record.
• The Angels have trailed after 3 innings in each of their last five night games against AL West opponents that held a losing record.
• The Angels have lost the first inning in five of their last six night games against AL West opponents that held a losing record.
• The Angels have trailed after 5 innings in eight of their last nine night games against American League opponents that held a losing record.

Total Runs Facts

• Seven of the Athletics’ last eight games as underdogs have gone OVER the total runs line.
• Seven of the Angels’ last eight games as favorites against AL West opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Angels’ last six games as favorites against AL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Athletics’ last seven road games against AL West opponents.

Matchup/League Facts

• The Angels rank 30th in the league for strikeouts against this season (1392).
• The Angels rank 30th in the league for walks allowed this season (539).
• The Athletics rank 2nd in the league for doubles this season (261).
• The Athletics rank 29th in the league for home runs allowed this season (198).

Athletics vs Angels Prediction

The Angels are 8-3 in their last 11 head-to-head meetings against the Athletics, and are 3-1 in their last 4 meetings in Los Angeles. Over is 8-2 in their last 10 meetings.

In this Athletics vs Angels Prediction, the Angels are coming as -135 home favorites. Both pitchers are coming into this matchup in terrible form, as they have a 7.01 and 7.04 ERA across their last 5 starts. In their previous start against the other team this season, they both gave up 4 earned runs, and both bullpens rank on the bottom-4 of the league in ERA. Yesterday’s game had 14 total runs, and I expect another high-scoring affair today. Take the over 9 runs in this one.