NRFI & YRFI Best Picks Today 08/06/2025 Today’s MLB Picks

Chicago Cubs vs Cincinnati Reds 2:20 PM EST

Pick: NRFI (No Runs First Inning)

The Chicago Cubs and Cincinnati Reds face off at Wrigley Field on Wednesday, August 6, 2025. The Cubs enter the game with a 65‑47 record, one of the best in the National League, and have already won the previous two series against the Reds this season. The Reds, sitting at 59‑54, are battling to stay alive in the NL Wild Card race, trailing by four games entering the series. This game features an intriguing pitching duel, with Andrew Abbott (8‑1, 2.15 ERA) taking the mound for Cincinnati and Cade Horton (5‑3, 3.42 ERA) starting for Chicago. I expect both of these pitchers to get out of the first inning without giving up a run. Abbott has been fantastic all season long, and Horton is in his best stretch of the season so far, not giving up a run in his last 3 starts combined. Also, it looks like there’s wind blowing towards the infield in Wrigley on Wednesday, which is great conditions for pitchers. 

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San Francisco Giants vs Pittsburgh Pirates 12:35 PM EST

Pick: NRFI (No Runs First Inning)

The San Francisco Giants and Pittsburgh Pirates meet at PNC Park on Wednesday, August 6, 2025, in a matchup that features two struggling teams trying to gain momentum late in the season. The Giants enter the game at 56‑57, hovering just below .500 as they attempt to climb the NL West standings, while the Pirates sit at 49‑64 and near the bottom of the NL Central. The pitching matchup features a duel between left-handers, with Robbie Ray starting for the Giants and Andrew Heaney taking the mound for the Pirates. Ray has been in excellent form, recently delivering his 14th quality start of the year with just one earned run over seven innings, while Heaney has been solid at home, posting a 4‑3 record and 3.25 ERA through 10 starts at PNC Park. I expect Robbie Ray to continue his success against this weak Pirates lineup, and Heaney should have a decent start as well, given how poorly this Giants lineup has performed over the last month. I like this to be a lower-scoring game, which should result in an NRFI.

Seattle Mariners vs Chicago White Sox 9:40 PM EST

Pick: NRFI (No Runs First Inning)

The Seattle Mariners take on the Chicago White Sox at T-Mobile Park on Wednesday, August 6, 2025, in a matchup between a Wild Card contender and a rebuilding team showing late-season life. Seattle enters at 60‑53, pushing to strengthen its playoff position, while Chicago sits at 42‑70 but has shown signs of improvement with a 10‑5 record since the All‑Star break. Jonathan Cannon takes the mound for the White Sox, and George Kriby takes the mound for the Mariners. Kirby is fully capable of getting out of this first inning without giving up a run. The real question is if Cannon can give us a solid inning. This should be a good spot for Cannon with this game being played in T-Mobile Park, which is the most pitcher-friendly ballpark in the MLB.