New York Yankees vs St. Louis Cardinals Prediction 8/16/2025 Today’s MLB Picks

In this article, we will formulate a Yankees vs Cardinals Prediction for this MLB game on Saturday, August 16th at the Busch Stadium in the second game of this series, with the Yankees having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 61-62 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 35-28 home record and are 60-57 in over/under They are coming off a 3-4 home defeat by the Yankees, and have three consecutive losses. Under is 6-2 in their last 8 games and are playing the Marlins and the Rays next.

The Cardinals have a .249 batting average this season, .318 OBP and .386 Slugging percentage. Saint Louis’ pitching staff has a 4.18 ERA and 1.28 WHIP. Brendan Donovan leads the Cardinals with 118 hits, while Alec Burleson is the team’s best hitter with a .279 batting average. Wilson Contreras leads the team in RBI, with 65, adding a team-high 16 home runs.

Sonny Gray (R) is the projected starting pitcher for the Cardinals, and he has a 11-5 record, 4.06 ERA and 1.15 WHIP.

New York Yankees Preview

The New York Yankees have a 65-57 record this season and are sitting on the third place of the AL East. The Yankees have a 28-32 road record and are 54-63 in over/under. They are coming off a 4-3 road victory over the Cardinals, and are 3-1 in their last 4 games. Under is 4-1 in their last 5 games and are playing the Rays and the Red Sox next.

The Yankees have a .249 batting average this season, .329 OBP and .445 Slugging percentage. New York’s pitching staff has a 4.01 ERA and 1.25 WHIP. Aaron Judge leads the Yankees with 134 hits, adding team-highs both in RBI, with 89 and in home runs, with 38. He is also the team’s best hitter, with a .330 batting average.

Max Fried (L) will take the mound for the Yankees, and he has a 12-5 record, 2.94 ERA and 1.10 WHIP.

Why the St. Louis Cardinals will win

• The Yankees have lost each of their last five games as road favorites following a win.
• The Cardinals have won five of their last six games as home underdogs against American League opponents following a loss.
• The Yankees have failed to cover the run line in each of their last eight road games.
• The Cardinals have covered the run line in each of their last six games as underdogs against American League opponents following a home loss.
• The Yankees have trailed after 5 innings in seven of their last eight Saturday games as favorites.
• The Cardinals have led after 3 innings in six of their last seven games against American League opponents.

Why the New York Yankees will win

• The Cardinals have lost each of their last six night games against AL East opponents that held a winning record.
• The Yankees have won each of their last six Saturday night games against National League opponents that held a losing record.
• The Cardinals have failed to cover the run line in seven of their last eight home games against American League opponents.
• The Yankees have covered the run line each of their last six Saturday night games against National League opponents that held a losing record.
• The Cardinals have trailed after 5 innings in each of their last nine home games against American League opponents that held a winning record.
• The Cardinals have lost the first inning in seven of their last eight night games against American League opponents.
• The Yankees have led after 3 innings in seven of their last eight night games against the Cardinals.

Total Runs Facts

• Each of the Yankees’ last four road games against NL Central opponents have gone UNDER the total runs line.
• Ten of the Cardinals’ last 12 night games against American League opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last seven home games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Yankees’ last four night games at Busch Stadium.

Matchup/League Facts

• The Cardinals rank 30th in the league for triples this season (4).
• The Cardinals rank 29th in the league for strikeouts this season (892).
• The Yankees rank 1st in the league for home runs this season (192).
• The Yankees rank 1st in the league for slugging percentage this season (.445).

Yankees vs Cardinals Prediction

The Cardinals are 7-3 in their last 10 meetings against the Yankees, and are 5-2 in their last 7 meetings in Saint Louis. Over is 3-1 in their last 4 meetings.

In this Yankees vs Cardinals Prediction, the Yankees are coming as -150 road favorites. Fried has been weaker on the road, and Gray has been better at home, but both pitchers are coming into this matchup in poor form. Fried is currently in his worst stretch of the season, having given up 4 runs in three of his last four starts, and he has a 1-4 record and 6.12 ERA across his last 5 starts. Gray has a 6.26 ERA in his last 5 starts, and both teams average 9.6 runs per game combined. With the total set at 8, which gives up push protection, I will go over the total in this one.