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New York Yankees vs Los Angeles Angels Prediction 5/28/25 MLB Picks

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Los Angeles Angels (25-29) vs New York Yankees (34-20)

May 28, 2025 at 09:38 PM EDT

The Line: Betting Odds: Los Angeles Angels +145 / New York Yankees -175 — Over/Under: 8.5

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The New York Yankees and the Los Angeles Angels meet Wednesday in MLB action from Angel Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a New York Yankees vs. Los Angeles Angels prediction.

Starting Pitching Matchup

The New York Yankees will send out Clarke Schmidt for the start here, and Schmidt is 1-2 with a 4.58 ERA and 38 strikeouts this season. This will be Schmidt’s second career start against the Angels. Yusei Kikuchi will get the start for the Angels here and is 1-4 with a 3.17 ERA and 54 strikeouts this season. In his last five starts against the Yankees, Kikuchi is 3-1 with a 2.30 ERA and 33 strikeouts.

New York Yankees Recap

The New York Yankees come into this game looking to build on their 3-2 win over the Angels from Tuesday’s matchup to improve to 34-20 on the year. After this series, the Yankees will head on the road for a marquee weekend series against the Los Angeles Dodgers.

Yankees Win Four In A Row & 8 Of Last 9

Aaron Judge leads the Yankees with 80 hits, including 18 home runs, 47 RBIs, 14 doubles, and a .398 batting average, along with 4 stolen bases. Anthony Volpe also had 16 doubles with 7 stolen bases, 6 home runs, and 31 RBIs, while Jasson Dominguez has added 9 doubles of his own. Paul Goldschmidt has 67 hits with 11 doubles and a .345 batting average, while Volpe also has a team-high 56 strikeouts so far this season. Ben Rice also has 39 hits with 11 doubles, 10 home runs, and 22 RBIs, while Cody Bellinger has 8 homers with 32 RBIs, and Austin Wells has 8 home runs and 31 RBIs, with both Bellinger and Wells chipping in 9 doubles apiece. Trent Grisham also has 12 home runs and 24 RBIs so far this season.

Why the New York Yankees will win

  • The Angels have lost 15 of their last 16 night games against American League opponents that held a winning record.
  • The Yankees have won each of their last six games against American League opponents.
  • The Angels have failed to cover the run line in 14 of their last 16 night games against American League opponents that held a winning record.
  • The road team has covered the run line in 10 of the Angels’ last 12 games.

New York Yankees Player Prop Facts

  • Aaron Judge has recorded at least one hit in each of the Yankees’ last 19 road games.
  • Giancarlo Stanton has recorded at least one RBI in each of his last nine road appearances.
  • Oswaldo Cabrera has scored at least one run in each of his last seven appearances in night games against AL West teams that held a losing record.
  • Giancarlo Stanton has hit a home run in four of his last five appearances with the Yankees against AL opponents.
  • Bryan De La Cruz has recorded at least one Single in each of his last eight road appearances against AL West opponents.
  • Aaron Judge ranks 1st in the league in Hits (81) this season.

Los Angeles Angels Recap

The Los Angeles Angels come into this game looking to bounce back from their loss at the hands of the Yankees on Tuesday, slipping to 25-29 on the year as a result. After this series, the Angels will head on the road for a series against the Cleveland Guardians.

Angels Drop Fourth Straight

Logan O’Hoppe has 44 hits, including 14 home runs and 30 RBIs, while Nolan Schanuel has 48 hits with 9 doubles, a triple, 3 home runs, and 14 RBIs. Luis Rengifo has 7 doubles with his 37 hits, and Taylor Ward also has 45 hits as well, while Mike Trout’s added 9 home runs and 18 RBIs so far this season. Jorge Soler also has 10 doubles, 7 home runs, and 21 RBIs, but also has 60 strikeouts so far this season. Kyren Paris has also chipped in 24 hits with a triple, 6 home runs, and 11 RBIs in addition to 7 stolen bases. Ward has also chipped in 11 doubles, 15 home runs, and 37 RBIs, but has a team-high 61 strikeouts, while Zach Neto has 10 doubles, 9 home runs, 20 RBIs, and 8 stolen bases.

Why the Los Angeles Angels will win

  • The Angels have won seven of their last 10 games as underdogs.
  • The Angels have covered the run line in each of their last seven Wednesday night games against the Yankees.
  • The Yankees have failed to cover the run line in each of their last seven Wednesday night games as favorites against American League opponents.

Los Angeles Angels Player Prop Facts

  • Taylor Ward has scored at least one run in seven of the Angels’ last eight night games.
  • Luis Rengifo has recorded a Single in each of his last seven appearances after playing the previous day.
  • Yusei Kikuchi has recorded six or more strikeouts in each of his last seven home appearances against AL East opponents.
  • Zach Neto has recorded at least one hit in each of his last nine appearances against AL opponents that held a winning record.
  • Mike Trout has hit a home run in three of his last four appearances at Angel Stadium of Anaheim against AL East opponents that held a winning record.
  • Mike Trout has recorded at least one RBI in five of his last six appearances with the Angels as home underdogs against AL opponents.
  • Taylor Ward ranks T6th in the league in Home Runs (15) this season.

Total Runs Facts

  • Each of the Yankees’ last seven games against AL West opponents have gone UNDER the total runs line.
  • Each of the Angels’ last four night games against AL East opponents have gone UNDER the total runs line.

New York Yankees vs. Los Angeles Angels Prediction

I’m on the Yankees here. The Angels made it interesting in the bottom of the 9th on Tuesday, but realistically, the Yankees are still the far better team here and the team I trust to make it happen once again on Wednesday. Kikuchi has had his ups and downs, and the Yankees have been smashing lefties lately. I think Schmidt is good enough for the Yankees to get the win here. Give me New York.

Chris Ruffolo's Pick: New York Yankees -175

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