Sep 19, 2025; Baltimore, Maryland, USA; Baltimore Orioles third baseman Jordan Westburg (11) scores during the sixth inning against the New York Yankees at Oriole Park at Camden Yards. Mandatory Credit: Daniel Kucin Jr.-Imagn Images

New York Yankees vs Baltimore Orioles Prediction 9/20/2025 Today’s MLB Picks

Pick details

New York (86-68) vs Baltimore (73-81)

September 20, 2025 at 07:05 PM EDT

The Line: Betting Odds: Yankees -205 / Orioles +165 — Over/Under: 9

(Get latest betting odds)

The New York Yankees and Baltimore Orioles meet on Saturday in MLB action from Oriole Park at Camden Yards. Here’s a New York Yankees vs Baltimore Orioles prediction. We will look at this from a betting perspective and determine the best Yankees vs Orioles pick. We will examine:

The New York Yankees’ recent form and player performance

The Baltimore Orioles’ recent form and player performance

Recent betting trends and streaks involving the Yankees

Recent betting trends and streaks involving the Orioles

Recent betting trends in games played between the Yankees and Orioles

A summary that ties it all together and produces a favorable betting outcome for the Orioles and Yankees game.

Yankees Bats Let Them Down


The Yankees bats let them down on Saturday and they have to get out to a faster start here. The Yankees scored only two runs, and although the pitching wasn’t awful, the offense just wasn’t good enough. Jazz Chisholm Jr was the only bright spot for the Yankees offense hitting a home run and driving in two RBIs. 

The Yankees are averaging 5.24 runs while their pitching is giving up 4.35 runs per game. The offense is ranked 1st in the league while the pitching is ranked 16th. Aaron Judge has hit 48 home runs and driven in 104 RBIs. Cody Bellinger has hit 29 home runs and driven in 71 RBIs so far this season. Carlos Rodon gets the start for the Yankees and he sits with a 16-9 record and a 3.11 ERA. Against the Minnesota Twins he went six innings giving up five hits and two runs. 

Why the Yankees WIll Beat the Orioles


The Yankees have won 11 of their last 12 night games against the Orioles following a road loss.
The Orioles have lost eight of their last nine games against AL East opponents that held a winning record.
The Orioles have failed to cover the run line in eight of their last nine games against the Yankees at Oriole Park at Camden Yards following a win.
The Yankees have covered the run line in seven of their last eight night games against the Orioles following a road loss.
The Orioles have trailed after 3 innings in three of their last four games at Oriole Park at Camden Yards against opponents that held a winning record.
The Orioles have trailed after 5 innings in three of their last four home games against opponents that held a winning record.
The Orioles have lost the first inning in three of their last four games as home underdogs against AL East opponents.

Can Orioles Close Season Strong?


The Orioles haven’t found a whole lot of success this season, but they still have to believe that they can close out the season strong. Some success in this series, would go a long way in making that happen. Ryan Mountcastle had a strong game hitting a home run and driving in two RBIs. Trevor Rogers has pitched really well for this team and he went six innings giving up only one hit and zero runs. 

The Orioles are averaging 4.25 runs while their pitching is giving up 4.69 runs per game. The offense is ranked 23rd while the pitching is ranked 24th. Jackson Holliday has hit 17 home runs and driven in 55 RBIs so far this year. Tomoyuki Sugano will get the start for the Orioles and he sits with a 10-8 record and an ERA of 4.39. In his last start against the Toronto Blue Jays, he went six innings giving up four hits and one run. 

Why The Orioles Will Beat the Yankees

The Yankees have lost each of their last five games as favorites against AL East opponents following a road loss.
The Orioles have won six of their last eight games as home underdogs following a home win.
The Orioles have covered the run line in seven of their last eight games as home underdogs following a home win.
The Yankees have failed to cover the run line in each of their last five games as favorites against AL East opponents following a road loss.

New York Yankees vs Baltimore Orioles Prediction 


Give me the Orioles and the value here. Rodon has been good obviously, this season, but let’s not overlook what Sugano has been able to do. In his last start he faced off against a very good Blue Jays offense and held them down. The Yankees are averaging 5.24 runs per game, but thier offense is going to really struggle to get anything going. The Orioles will only need 4 or 5 runs to get the job done, and they will reach that number. Back the Orioles on the money line. I also am sprinkling a few days on the Orioles on the reverse run line.

Shane Mickle's Pick: Orioles ML

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