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Minnesota Twins vs Houston Astros Prediction 6/14/25 MLB Picks

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Houston Astros (39-30) vs Minnesota Twins (36-33)

June 14, 2025 at 04:10 PM EDT

The Line: Betting Odds: Houston Astros -127 / Minnesota Twins +104 — Over/Under: 7

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The Minnesota Twins and the Houston Astros meet Saturday in MLB action from Daikin Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Minnesota Twins vs. Houston Astros prediction.

Starting Pitching Matchup

The Minnesota Twins will send out Joe Ryan for the start here, and Ryan is 7-2 with a 2.96 ERA and 82 strikeouts this season. The Astros will send out Hunter Brown for the start here, and Brown is 8-3 with a 1.82 ERA and 93 strikeouts this season

Minnesota Twins Recap

The Minnesota Twins come into this game looking to bounce back from their 10-3 loss at the hands of the Astros from Friday’s series opener to sit at 36-33 on the year. After this series, the Twins will head on the road for a series against the Cincinnati Reds.

Twins Drop 6 Of Their Last 8

Byron Buxton has 55 hits along with 8 doubles, a team-high 11 home runs, and 41 RBIs with 11 stolen bases and 3 triples, while Carlos Correa has 52 hits with 13 doubles, and Willi Castro has 46 hits with 10 doubles as well. Harrison Bader added 6 home runs and 24 RBIs while Buxton contributed a team-high 64 strikeouts as well this season. Ty France has also added 67 hits, 11 doubles, 4 home runs, and 36 RBIs, and Trevor Larnach chipped in 63 hits with 9 doubles, 10 home runs, and 32 RBIs as well this season.

Why the Minnesota Twins will win

  • The Twins have won 11 of their last 12 games as underdogs against AL West opponents following a loss.
  • The Astros have lost five of their last six games as favorites against the Twins following a win.
  • The Twins have covered the run line in each of their last 12 games as underdogs against AL West opponents following a loss.
  • The Astros have failed to cover the run line in each of their last four games as home favorites against AL Central opponents following a win.

Minnesota Twins Player Prop Facts

  • Trevor Larnach has hit a home run in each of his last two road appearances against the Astros.
  • Carlos Correa has recorded at least one Double in three of his last four appearances with the Twins as road underdogs against the Astros.
  • Carlos Correa has recorded at least one RBI in seven of his last eight appearances with the Twins as underdogs against AL West opponents.
  • Joe Ryan has recorded seven or more strikeouts in four of his last five appearances with the Twins as underdogs against AL opponents.
  • Byron Buxton has scored at least one run in each of his last five appearances with the Twins as road underdogs.
  • Ty France has recorded at least one hit in each of his last nine appearances with his team as an underdog against AL West opponents.
  • Joe Ryan has recorded a win in five of his last six appearances.
  • Joe Ryan ranks T6th in the league for Wins (7) this season.

Houston Astros Recap


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The Houston Astros come into this game looking to add on to their win over the Twins from Friday’s matchup to sit at 39-30 on the year. After this series, the Astros will head on the road for a series against the Athletics.

Astros Win Three Straight & Six Of Last Eight

Jose Altuve has 70 hits, including 9 doubles, 9 home runs, and 27 RBIs. Jeremy Pena also has 85 hits with 14 doubles, 9 homers, and 33 RBIs with 14 stolen bases, while Yordan Alvarez has 4 doubles and 18 RBIs with 21 strikeouts as well. Jake Meyers has 11 doubles as well, and Christian Walker has 9 home runs and 33 RBIs, but has also accrued a team-high 75 strikeouts so far this season. Altuve also has 6 stolen bases, while Jake Meyers has 10 stolen bases this season. Isaac Paredes also has a team-high 15 home runs with 42 RBIs of his own, and Cam Smith has contributed 3 homers and 20 RBIs.

Why the Houston Astros will win

  • The Twins have lost seven of their last eight day games against American League opponents.
  • The Astros have won each of their last four home games after playing the previous day.
  • The Twins have failed to cover the run line in each of their last six Saturday day games as underdogs against AL West opponents.
  • The Astros have covered the run line in four of their last five games against the Twins.

Houston Astros Player Prop Facts

  • Jeremy Pena has recorded a Double in four of the Astros’ last five games against AL Central opponents at Daikin Park.
  • Jeremy Pena has scored at least one run in each of the Astros’ last six home games.
  • Jeremy Pena has recorded two or more hits in each of the Astros’ last eight home games against AL Central opponents.
  • Isaac Paredes has hit a home run in each of his last two appearances at Daikin Park against AL Central opponents that held a winning record.
  • Isaac Paredes has recorded at least one RBI in each of his last five home appearances against AL Central opponents.
  • Hunter Brown ranks T2nd in the league for Wins (8) this season.

Total Runs Facts

  • Seven of the Twins’ last eight games have gone OVER the total runs line.
  • Six of the Astros’ last seven day games against AL Central opponents have gone OVER the total runs line.

Minnesota Twins vs. Houston Astros Prediction

I’m on the Astros here. I get the case to be made for the Twins as the Twins have been winning a lot of Joe Ryan’s starts, and Ryan’s been picking up the win in a lot of his outings as well, and bolstering his strong win-loss record this season. However, the Astros have had his number for the better part of his career, and the Astros are playing their best baseball at home by a mile so far this season. Hunter Brown has also been stellar at Daikin Park so far this season, and I just think that he outduels Ryan here. Give me the Astros.

Chris Ruffolo's Pick: Houston Astros -127


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