May 9, 2026; Cleveland, Ohio, USA; Minnesota Twins center fielder Byron Buxton (25) celebrates his RBI double in the eleventh inning against the Cleveland Guardians at Progressive Field. Mandatory Credit: David Richard-Imagn Images
David Richard-Imagn Images

Minnesota Twins vs Cleveland Guardians Prediction 5/10/2026 Today’s MLB Picks

Pick details

MATCHUP Minnesota Twins Cleveland Guardians
Team Records 17-23 21-20
Spread +1.5 -181 -1.5 149
Moneyline +124 -150
Total Over 7.5 (-110) Under 7.5 (-110)
Where Progressive Field, Cleveland, Ohio
When Sunday, May 10, 2026
Time 01:40 PM EDT
TV MLB.TV

The Minnesota Twins and Cleveland Guardians meet Sunday in MLB action at Progressive Field. Here’s a Minnesota Twins vs. Cleveland Guardians Prediction. This article will include a Minnesota Twins vs. Cleveland Guardians Pick.

Minnesota Twins Betting Preview


The Minnesota Twins are 17-23 on the year and play the Marlins and Brewers next. The Minnesota Twins are batting .234 on the season and have a .323 OBP, and a .381 slugging percentage. The Minnesota Twins pitching staff has a 4.64 ERA and a 1.37 WHIP. Byron Buxton leads the Minnesota Twins with 41 hits and 21 RBI, while Luke Keaschall and Brooks Lee have combined for 68 hits and 38 RBI.

Andrew Morris gets the ball for the Minnesota Twins, and he is 1-1 with a 4.96 ERA and 15 strikeouts this season. This will be Morris’ second career game against the Cleveland Guardians.

Cleveland Guardians Betting Preview


The Cleveland Guardians are 21-20 on the year and play the Angels and Reds next. The Cleveland Guardians are batting. 228 on the season, have a .319 OBP, and have a .369 slugging percentage. The Cleveland Guardians pitching staff has a 3.91 ERA and a 1.27 WHIP. Chase DeLauter leads the Cleveland Guardians with 38 hits and 23 RBI while Brayan Rocchio and Jose Ramirez have combined for 66 hits and 34 RBI.

Gavin Williams gets the ball for the Cleveland Guardians, and he is 5-2 with a 3.28 ERA and 60 strikeouts this season. Williams is 3-2 with a 2.61 ERA and 30 strikeouts in his career against the Minnesota Twins.

Why the Cleveland Guardians will win

  • The Twins have lost each of their last eight day games at Progressive Field following a win.
  • The Guardians have won nine of their last 10 games following a home loss.
  • The Twins have failed to cover the run line in seven of their last eight road games after playing the previous day.
  • The Guardians have covered the run line in seven of their last eight games following an extra innings loss.
  • The Twins have trailed after 5 innings in nine of their last 11 road games.

Why the Minnesota Twins will win

  • The underdogs have won four of the Guardians’ last five games.
  • The Guardians have lost three of their last four games as favorites.
  • The Guardians have failed to cover the run line in each of their last nine Sunday games against AL Central opponents.
  • The underdogs have covered the run line in 12 of the last 13 games between the Twins and Guardians at Progressive Field.
  • The Twins have led after 3 innings in three of their last four games against American League opponents.

Total Runs Facts

  • Seven of the Twins’ last eight day games against AL Central opponents have gone UNDER the total runs line.
  • Five of the Guardians’ last six games as home favorites have gone UNDER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Twins’ last four games as underdogs against American League opponents.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the last six games between the Twins and Guardians at Progressive Field.

Cleveland Guardians Player Prop Facts

  • Jose Ramirez has recorded at least one hit in each of the Guardians’ last eight games as favorites against the Twins.
  • Rhys Hoskins has hit a home run in three of his six previous home appearances against the Twins after playing the previous day.
  • Gavin Williams ranks T3rd in the league for total Strikeouts (60) this season.

Minnesota Twins Player Prop Facts

  • Byron Buxton has hit a home run in five of the Twins’ last six games as underdogs against AL opponents.
  • Ryan Jeffers has recorded a hit in each of his last six appearances against the Guardians.

Matchup/League Facts

  • The Guardians rank 2nd in the league for strikeouts this season (377).
  • The Guardians rank 3rd in the league for walks this season (168).
  • The Twins rank 7th in the league for walks this season (156).
  • The Twins rank 24th in the league for ERA this season (4.64).

Minnesota Twins vs Cleveland Guardians Prediction


The Twins have had issues on the road all season and Morris isn’t the guy to turn things around. Despite just 16.1 innings, Morris has a 4.96 ERA and 1.53 WHIP. He’s a rookie who is still trying to find his footing. The Guardians have had success with Williams on the bump, and he’s far more trustworthy with his 3.28 ERA and 1.09 WHIP. Williams needs to trim down the walks, but with the quick turnaround, I’ll side with Cleveland at home.

Randy Chambers's Pick: Cleveland Guardians

Hot Cappers