Minnesota Twins vs Cleveland Guardians Prediction 08/01/2025 Picks

The Minnesota Twins and Cleveland Guardians meet Friday in MLB action at Sutter Health Park. Here’s a Minnesota Twins vs Cleveland Guardians Prediction. This article will include a Minnesota Twins vs Cleveland Guardians Pick.

Minnesota Twins Betting Preview

The Minnesota Twins are 51-57 on the year and play the Tigers, Royals, and Yankees next. The Minnesota Twins are batting .241 on the season, have a .313 OBP, and a .399 slugging percentage. The Minnesota Twins pitching staff has a 4.29 ERA and a 1.27 WHIP. Byron Buxton leads the Minnesota Twins with 92 hits and 59 RBI, while Carlos Correa and Ty France have combined for 178 hits and 75 RBI. 

Joe Ryan gets the ball for the Minnesota Twins, and he is 10-5 with a 2.82 ERA and 137 strikeouts this season. Ryan is 3-4 with a 2.58 ERA and 48 strikeouts in his career against the Cleveland Guardians.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 54-54 on the year and play the Mets, White Sox, and Marlins next. The Cleveland Guardians are batting .228 on the season, have a .301 OBP, and a .377 slugging percentage. The Cleveland Guardians pitching staff has a 3.90 ERA and a 1.31 WHIP. Jose Ramirez leads the Cleveland Guardians with 118 hits and 56 RBI while Steven Kwan and Carlos Santana have combined for 196 hits and 84 RBI.

Gavin Williams gets the ball for the Cleveland Guardians, and he is 6-4 with a 3.51 ERA and 109 strikeouts this season. Williams is 3-2 with a 3.24 ERA and 22 strikeouts in his career against the Minnesota Twins.

Why the Cleveland Guardians will win

• The Guardians have won 10 of their last 11 games against the Twins following a win.
• The Twins have lost eight of their last nine games against the Guardians following a home loss.
• The Twins have failed to cover the run line in seven of their last eight games against American League opponents.
• The Guardians have covered the run line in 10 of their last 11 games against the Twins following a win.
• The Guardians have led after 5 innings in five of their last six night games.

Why the Minnesota Twins will win

• The underdogs have won four of the Twins’ last five games at Progressive Field.
• The Guardians have lost seven of their last eight Friday night games.
• The underdogs have covered the run line in each of the Twins’ last eight games at Progressive Field.
• The Guardians have failed to cover the run line in four of their last five games against American League opponents.

Why the Minnesota Twins will win

• The underdogs have won four of the Twins’ last five games at Progressive Field.
• The Guardians have lost seven of their last eight Friday night games.
• The underdogs have covered the run line in each of the Twins’ last eight games at Progressive Field.
• The Guardians have failed to cover the run line in four of their last five games against American League opponents.

Minnesota Twins Player Prop Facts

• Joe Ryan has recorded seven or more strikeouts in each of his last three appearances against AL opponents.
• Carlos Correa has recorded at least one hit in each of his last six appearances.
• Byron Buxton has hit a home run in each of his last two road appearances after not playing the previous day.

Minnesota Twins vs Cleveland Guardians Prediction

You can make a case for either team with the pitchers on the mound. The Guardians should probably have the edge at home, especially with the Twins having a rough week. However, Ryan is hard to bet against with his 2.82 ERA and 0.92 WHIP, and he’s allowed nine earned runs in his last 36 innings. In 61 road innings, Ryan has a 2.51 ERA and .199 allowed batting average. Ryan has been a top-five pitcher in the AL this season, the sort of guy capable of getting the Twins back on track. That’s where I’ll lean on Friday.