May 27, 2026; Chicago, Illinois, USA;  Chicago White Sox second baseman Chase Meidroth (10) is dunked by left fielder Sam Antonacci (10) left, and shortstop Colson Montgomery (12) after the game against the Minnesota Twins at Rate Field. Mandatory Credit: Matt Marton-Imagn Images
Matt Marton-Imagn Images

Minnesota Twins vs Chicago White Sox Prediction 5/28/2026 Today’s MLB Picks

Pick details

MATCHUP Minnesota Twins Chicago White Sox
Team Records 27-29 28-27
Spread +1.5 -188 -1.5 155
Moneyline +113 -136
Total Over 8 (-105) Under 8 (-114)
Where Rate Field, Chicago, Illinois
When Thursday, May 28, 2026
Time 02:10 PM EDT
TV MLB.TV

The Minnesota Twins and Chicago White Sox meet on Thursday in MLB action at Comerica Park. Here’s a Minnesota Twins vs Chicago White Sox Prediction. This article will include a Minnesota Twins vs Chicago White Sox Pick.

Minnesota Twins Betting Preview


The Minnesota Twins are 27-29 on the year and play the White Sox and Pirates next. The Minnesota Twins are batting .236 on the season and have a .319 OBP and a .385 slugging percentage. The Minnesota Twins’ pitching staff has a 4.33 ERA and a 1.33 WHIP. Byron Buxton leads the Minnesota Twins with 51 hits and 27 RBI, while Luke Keaschall and Brooks Lee have combined for 92 hits and 48 RBI.

Kendry Rojas gets the ball for the Minnesota Twins, and he is 1-0 with a 1.26 ERA and 14 strikeouts this season. This will be Rojas’ first career game against the Chicago White Sox.

Chicago White Sox Betting Preview


The Chicago White Sox are 28-27 on the year and play the Twins and Tigers next. The Chicago White Sox are batting .236 on the season, have a .325 OBP, and have a .403 slugging percentage. The Chicago White Sox pitching staff has a 4.40 ERA and a 1.33 WHIP. Chase Meidroth leads the Chicago White Sox with 54 hits and 18 RBI, while Munetaka Murakami and Miguel Vargas have combined for 92 hits and 71 RBI.

Davis Martin gets the ball for the Chicago White Sox, and he is 7-1 with a 2.04 ERA and 66 strikeouts this season. Martin is 2-3 with a 6.15 ERA and 21 strikeouts in his career against the Minnesota Twins.

Why the Chicago White Sox will win

  • The White Sox have won eight of their last nine games against the Twins.
  • The Twins have lost four of their last five games against the White Sox following a loss.
  • The White Sox have covered the run line in each of their last eight day games against American League opponents following a home win.
  • The Twins have failed to cover the run line in 10 of their last 11 Thursday day games against AL Central opponents that held a winning record.
  • The Twins have trailed after 5 innings in six of their last seven day games at Rate Field against American League opponents.

Why the Minnesota Twins will win

  • The Twins have won five of their last six games as underdogs against American League opponents.
  • The White Sox have lost five of their last six games as favorites against American League opponents following a win.
  • The Twins have covered the run line in each of their last six games following a loss.
  • The White Sox have failed to cover the run line in each of their last four games as home favorites following a win.

Total Runs Facts

  • Seven of the White Sox’s last eight home games against AL Central opponents have gone OVER the total runs line.
  • Nine of the Twins’ last 12 road games have gone OVER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Twins’ last five games as underdogs.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last four day games between the Twins and White Sox at Rate Field.

Chicago White Sox Player Prop Facts

  • Austin Hays has recorded at least one hit in seven of his last eight home appearances against AL opponents.
  • Andrew Benintendi has hit a home run in three of his last 10 appearances with the White Sox as home favorites against AL opponents.

Minnesota Twins Player Prop Facts

  • Byron Buxton has hit at least one home run in three of his last four appearances at Rate Field against AL Central opponents that held a winning record.
  • Byron Buxton has recorded at least one hit in each of his last eight appearances with the Twins as road underdogs.

Minnesota Twins vs Chicago White Sox Prediction


Quick turnaround and a lot of offense yesterday, it feels like things calm down here. Rojas has pitched just 14.1 innings in his big league career, but he has a 1.26 ERA and 1.47 WHIP. Martin has a 2.04 ERA and 1.02 WHIP through 61.2 innings. Martin has allowed 19 hits and 6 runs in his last 24.2 innings. In 23.2 home innings, Martin has a 1.14 ERA and a .216 allowed batting average. Two pitchers in fantastic form. Give me the under in this spot.

Randy Chambers's Pick: Under 8

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