Minnesota Twins vs Athletics Prediction 6/4/25 MLB Picks

The Minnesota Twins and the Athletics meet Wednesday in MLB action from Sutter Health Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Minnesota Twins vs. Athletics prediction.

Starting Pitching Matchup

The Minnesota Twins will send out Zebby Matthews for the start here and is 0-1 with a 6.43 ERA and 21 strikeouts this season. This will be Matthews’ first career start against the Athletics. The Athletics did not have a starting pitcher announced at the time that this article was published.

Minnesota Twins Recap

The Minnesota Twins come into this game looking to build on their 10-3 win over the Athletics last time out to improve to 33-27 on the year. After this series, the Twins go back home for a weekend series with the Toronto Blue Jays.

Twins Win Back-To-Back Games

Byron Buxton has 47 hits along with 6 doubles, a team-high 10 home runs, and 35 RBIs with 10 stolen bases and 3 triples, while Carlos Correa has 45 hits with 11 doubles, and Willi Castro has 34 hits with 9 doubles as well. Harrison Bader added 5 home runs and 22 RBIs while Buxton contributed a team-high 59 strikeouts as well this season. Ty France has also added 56 hits, 9 doubles, 4 home runs, and 32 RBIs, and Trevor Larnach chipped in 56 hits with 8 home runs and 29 RBIs as well this season.

Why the Minnesota Twins will win

• The Athletics have lost each of their last 14 night games after playing the previous day.
• The Twins have won each of their last 10 games against American League opponents that held a losing record.
• The Twins have covered the run line each of their last 10 games against American League opponents that held a losing record.
• The Athletics have failed to cover the run line in each of their last 10 night games against American League opponents.

Minnesota Twins Player Prop Facts

• Trevor Larnach has recorded at least one RBI in eight of his last nine road appearances against AL West opponents that held a losing record.
• Ty France has recorded a Double in three of the Twins’ last four games against AL West opponents that held a losing record.
• Byron Buxton has scored at least one run in each of his last nine Wednesday appearances against teams that held a losing record.
• Trevor Larnach has recorded at least one hit in each of his last 15 appearances against AL West opponents.
• Byron Buxton has hit a home run in three of the Twins’ last five night games against AL opponents that held a losing record.
• Trevor Larnach has recorded at least one Single in each of the Twins’ last seven games against AL West opponents.

Athletics Recap

The Athletics come into this game looking to bounce back from their loss on Tuesday to fall to 23-39 on the year. After this series, the Athletics will take on the Baltimore Orioles in a weekend set.

Athletics Continue To Slide

Jacob Wilson leads the Athletics with 81 hits, 13 doubles, and a .355 batting average, while Tyler Soderstrom has 59 hits with 11 doubles, 12 home runs, and 36 RBIs this season. Brent Rooker has 65 hits with 11 doubles, 13 home runs, and 32 RBIs, but also has 61 strikeouts this season, while JJ Bleday has 34 hits with 9 doubles, and Gio Urshela has 9 doubles. Shea Langeliers has 46 hits with 10 home runs and 26 RBIs, while Lawrence Butler also chipped in 9 stolen bases and 17 doubles as part of his 59 hits as well as 9 home runs and 27 RBIs.

Why the Athletics will win

• The Athletics have won four of their last five night games against AL Central opponents following a home loss.
• The Twins have lost seven of their last nine night games against the Athletics following a road win.
• The Twins have failed to cover the run line in six of their last seven games following a win.
• The Athletics have covered the run line in eight of their last 10 night games against AL Central opponents following a loss.

Athletics Player Prop Facts

• Lawrence Butler has recorded at least one hit in each of the Athletics’ last 11 night games.
• Lawrence Butler has hit a home run in two of his last three home appearances with the Athletics against AL opponents.
• Brent Rooker has recorded at least one Single in eight of the Athletics’ last nine games against AL opponents that held a winning record.
• Brent Rooker has recorded at least one RBI in six of his last seven appearances in night games against AL Central teams that held a winning record.
• Lawrence Butler has recorded at least one Double in five of the Athletics’ last six night games against opponents that held a winning record.
• Lawrence Butler has scored at least one run in each of his last seven home appearances after playing the previous day.

Total Runs Facts

• Each of the Athletics’ last seven night games against American League opponents have gone OVER the total runs line.
• Each of the Twins’ last six night games against AL West opponents have gone OVER the total runs line.

Minnesota Twins vs. Athletics Prediction

I’m backing the Twins here. The Athletics continue to struggle and keep finding different ways to lose as each day goes by, and have gotten back to looking like the Athletics we’ve gotten used to seeing in each of the last couple of seasons. The Twins haven’t been playing overly well as of late in their own right, but the Twins are still the better team by a mile right now, and until the Athletics show a pulse, I have to roll the other way. Give me the Twins in this one to pick up another W and add to the Athletics’ misery.