Milwaukee Brewers vs St. Louis Cardinals Prediction 9/21/2025 Today’s MLB Picks

In this article, we will formulate a Brewers vs Cardinals Prediction for this MLB game on Sunday, September 21st at the Busch Stadium in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 75-80 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 43-37 home record and are 77-70 in over/under. They are coming off a 2-3 home defeat by the Brewers, and are still 3-8 in their last 11 games. They are playing the Cubs and the Giants next.

The Cardinals have a .246 batting average this season, .315 OBP and .378 Slugging percentage. Saint Louis’ pitching staff has a 4.25 ERA and 1.32 WHIP. Alec Burleson leads the Cardinals with 137 hits, and he is the team’s best hitter with a .289 batting average. Wilson Contreras leads the team in RBI, with 80, adding a team-high 20 home runs.

Matthew Liberatore (L) is the projected starting pitcher for the Cardinals, and he has a 7-12 record, 4.30 ERA and 1.31 WHIP.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 95-60 record this season and are sitting on the first place of the NL Central. They have a 44-33 road record and are 75-75 in over/under. They are coming off a 3-2 road victory over the Cardinals, and are 4-1 in their last 5 games. Over is 8-3 in their last 11 games and are playing the Reds and the Padres next.

The Brewers have a .261 batting average this season, .334 OBP and .409 Slugging percentage. Milwaukee’s pitching staff has a 3.61 ERA and 1.23 WHIP. Brice Turang leads the Brewers with 161 hits, while Christian Yelich leads the team in RBI, with 100, adding a team-high 29 home runs. Sal Frelick is the team’s best hitter with a .294 batting average.

Freddy Peralta (R) is the projected starting pitcher for the Brewers, and he has a 17-6 record, 2.65 ERA and 1.07 WHIP.

Milwaukee Brewers @ St. Louis Cardinals Betting Trends: September 21, 2025

• Probable Starting Pitcher: Matthew Liberatore      Record this season: 7-12      ERA: 4.30
• Home Record: 5-5
• Last 5 against Brewers: 1-0

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last five games as home underdogs following an extra innings loss.
• The Brewers have lost four of their last five games as road favorites.
• The Brewers have failed to cover the run line in each of their last seven games against the Cardinals following a win.
• The underdogs have covered the run line in 10 of the Cardinals’ last 11 games at Busch Stadium.
• The Cardinals have led after 3 innings in five of their last six games as underdogs.
• The Cardinals have won the first inning in three of their last four games.
• The Brewers have trailed after 5 innings in each of their last five road games.

• Probable Starting Pitcher: Freddy Peralta      Record this season: 17-6      ERA: 2.65
• Road Record: 8-5
• Last 5 against Cardinals: 2-0

Why the Milwaukee Brewers will win

• The Brewers have won each of their last nine games as favorites against National League opponents following a road win.
• The Cardinals have lost four of their last five day games at Busch Stadium following a loss.
• The Cardinals have failed to cover the run line in each of their last seven Sunday day home games.
• The Brewers have covered the run line in each of their last five road games following an extra innings win.
• The Brewers have led after 5 innings in five of their last six day games against NL Central opponents that held a losing record.
• The Brewers have led after 3 innings in five of their last six day games against NL Central opponents that held a losing record.

Total Runs Facts

• Seven of the Cardinals’ last eight home games after playing the previous day have gone UNDER the total runs line.
• Four of the Brewers’ last five road games after going to extra innings have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Cardinals’ last six day games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Brewers’ last nine games at Busch Stadium.

St. Louis Cardinals Player Prop Facts

• Nolan Arenado has hit a home run in five of his last 13 home appearances against the Brewers after playing the previous day.
• Brendan Donovan has recorded at least one hit in each of his last 11 appearances against the Brewers.
• Brendan Donovan has recorded a Double in three of the Cardinals’ last four home games against the Brewers.

Milwaukee Brewers Player Prop Facts

• Sal Frelick has hit a home run in two of his last three appearances.
• Sal Frelick has recorded at least one hit in each of his last 12 appearances against NL Central opponents.
• Freddy Peralta has recorded a win in each of his last five road appearances against NL opponents.
• Andrew Vaughn has recorded a Double in each of his last three appearances.
• Sal Frelick ranks 10th amongst qualified players for Batting Average (.294) this season.

Matchup/League Facts

• The Cardinals rank 30th in the league for triples this season (8).
• The Cardinals rank 29th in the league for strikeouts this season (1151).
• The Brewers rank 2nd in the league for hits this season (1378).
• The Brewers rank 2nd in the league for batting average this season (.261).

Brewers vs Cardinals Prediction

The Brewers are 7-3 in their last 10 head-to-head meetings against the Cardinals, but the Cardinals are 3-2 in their last 5 meetings in Saint Louis.

In this Brewers vs Cardinals Prediction, the Brewers are coming as -140 road favorites. The Brewers bounced back yesterday after Friday’s loss and are putting their ace on the mound in Freddy Peralta, who has 17 wins this season, and has been red-hot lately, with one earned run or less in seven of his last eight starts. On the flip side, Liberatore has a 5.11 ERA across his last 5 starts for the Cardinals, who also have a weaker offense. This is good price for the road team who has a huge pitching advantage in this game, so take the Milwaukee Brewers on the moneyline on the road.