Milwaukee Brewers vs St. Louis Cardinals Prediction 9/19/2025 Today’s MLB Picks

In this article, we will formulate a Brewers vs Cardinals Prediction for this MLB game on Friday, September 19th at the Busch Stadium in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 74-79 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 42-36 home record and are 76-69 in over/under. They are coming off a 2-6 home defeat by the Reds, and are 2-7 in their last 9 games. Under is 3-1 in their last 4 games and are playing the Cubs and the Giants next.

The Cardinals have a .244 batting average this season, .314 OBP and .378 Slugging percentage. Saint Louis’ pitching staff has a 4.29 ERA and 1.32 WHIP. Alec Burleson leads the Cardinals with 133 hits, and he is the team’s best hitter with a .285 batting average. Wilson Contreras leads the team in RBI, with 80, adding a team-high 20 home runs.

Sonny Gray (R) is the projected starting pitcher for the Cardinals, and he has a 13-8 record, 4.43 ERA and 1.22 WHIP.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 94-59 record this season and are sitting on the first place of the NL Central. They have a 43-32 road record and are 74-74 in over/under. They are coming off a 9-2 home victory over the Angels, and are 4-1 in their last 5 games. Over is 7-2 in their last 9 games and are playing the Reds and the Padres next.

The Brewers have a .261 batting average this season, .334 OBP and .409 Slugging percentage. Milwaukee’s pitching staff has a 3.60 ERA and 1.22 WHIP. Brice Turang leads the Brewers with 160 hits, while Christian Yelich leads the team in RBI, with 100, adding a team-high 29 home runs. Sal Frelick is the team’s best hitter with a .296 batting average.

Jacob Misiorowski (R) is the projected starting pitcher for the Brewers, and he has a 5-2 record, 4.35 ERA and 1.13 WHIP.

Milwaukee Brewers @ St. Louis Cardinals Betting Trends: September 19, 2025

• Probable Starting Pitcher: Sonny Gray      Record this season: 13-8      ERA: 4.43
• Home Record: 9-5
• Last 5 against Brewers: 0-2

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last four games as underdogs following a home loss.
• The Brewers have lost each of their last three games as road favorites.
• The Brewers have failed to cover the run line in each of their last six games against the Cardinals following a win.
• The Cardinals have covered the run line in nine of their last 10 games as underdogs against National League opponents following a loss.
• The Cardinals have led after 3 innings in each of their last four games as underdogs.
• The Cardinals have led after 5 innings in four of their last five games against NL Central opponents that held a winning record.
• The Cardinals have won the first inning in three of their last four games as underdogs.

• Probable Starting Pitcher: Jacob Misiorowski      Record this season: 5-2      ERA: 4.35
• Road Record: 2-2
• Last 5 against Cardinals: 1-0

Why the Milwaukee Brewers will win

• The Brewers have won each of their last 10 road games against teams that held a losing record.
• The Cardinals have lost each of their last five night games against teams that held a winning record.
• The Brewers have covered the run line each of their last 10 road games against teams that held a losing record.
• The Cardinals have failed to cover the run line in seven of their last eight games against the Brewers following a home loss.
• The Brewers have led after 5 innings in nine of their last 10 road games against opponents that held a losing record.

Total Runs Facts

• Each of the Cardinals’ last five games as home underdogs have gone UNDER the total runs line.
• Six of the Brewers’ last eight games have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Brewers’ last four night games at Busch Stadium.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the last seven games between the Brewers and Cardinals at Busch Stadium.

St. Louis Cardinals Player Prop Facts

• Lars Nootbaar has hit a home run in two of his last three home appearances against NL Central opponents that held a winning record.
• Sonny Gray has recorded six or more strikeouts in each of his seven previous appearances with his team as an underdog against the Brewers.
• Brendan Donovan has recorded at least one hit in each of his last nine appearances against the Brewers.
• Sonny Gray has recorded a win in four of his last five home appearances against NL opponents that held a winning record.
• Victor Scott II ranks T9th in the league in Steals (33) this season.

Milwaukee Brewers Player Prop Facts

• Christian Yelich has hit a home run in three of his last four appearances in night games against NL Central teams that held a losing record.
• Jackson Chourio has recorded a Double in each of the Brewers’ last four road games against the Cardinals.
• Brice Turang has recorded at least one hit in each of the Brewers’ last 11 games as road favorites against NL opponents.
• Sal Frelick ranks 10th amongst qualified players for Batting Average (.296) this season.

Matchup/League Facts

• The Cardinals rank 30th in the league for triples this season (8).
• The Cardinals rank 29th in the league for strikeouts this season (1135).
• The Brewers rank 2nd in the league for runs scored this season (785).
• The Brewers rank 2nd in the league for hits this season (1357).

Brewers vs Cardinals Prediction

The Brewers are 6-2 in their last 8 head-to-head meetings against the Cardinals, but the Cardinals are 2-1 in their last 3 meetings in Saint Louis.

In this Brewers vs Cardinals Prediction, the Brewers are coming as -120 road favorites. Brewers have been the best team in baseball this season, and have been red-hot lately, but this is a tricky spot for them. The Cardinals are still 5 wins behind the Wild Card Spot in the NL, and are putting their ace on the mound in Sonny Gray. On the flip side, the Brewers are putting Misiorowski on the mound, who has been struggling lately, and has been bad on the road, with a 5.61 road ERA. The total is set too low, given both pitchers’ form, with just 7.5 runs. Both pitchers have been struggling lately, having 4.97 and 5.08 ERA in their last 5 starts respectively, and both teams are slightly better against righties, with 9.8 average runs combined. The Brewers have scored 8+ runs in four of their last six games, and the Cardinals have allowed 6+ runs in four of their last six. Go over the 7.5 runs in this one.