Milwaukee Brewers vs San Diego Padres Prediction 9/24/2025 Today’s MLB Picks

In this article, we will formulate a Brewers vs Padres Prediction for this MLB game on Wednesday, September 24th at the Petco Park in the third game of this series, with the Padres having the 2-0 lead. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Preview

The San Diego Padres have an 87-71 record this season and are sitting on the 2nd place of the NL West. The Padres have a 49-28 home record and are 67-85 in over/under. They are coming off a 7-0 home victory over the Brewers, and have four consecutive wins. They are playing the Diamondbacks next.

The Padres have a .252 batting average this season, .320 OBP and .388 slugging percentage. San Diego’s pitching staff has a 3.65 ERA and 1.20 WHIP. Luis Arraez leads the Padres with 175 hits, and he is the team’s best hitter with .288 batting average. Manny Machado leads the team in RBI, with 93 and in home runs, with 26.

Dylan Cease (R) is the projected starting pitcher for the Padres, and he has an 8-12 record, 4.64 ERA and 1.32 WHIP.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 95-63 record this season and are sitting on the 1st place of the NL Central. The Brewers have a 44-36 road record and are 76-77 in over/under. They are coming off a 0-7 road defeat by the Padres, and are 1-4 in their last 5 games. They are playing the Reds next.

The Brewers have a .259 batting average this season, .333 OBP and .405 slugging percentage. Milwaukee’s pitching staff has a 3.63 ERA and 1.23 WHIP. Brice Turang leads the Brewers with 162 hits, while Sam Frelick is the team’s best hitter, with a .291 batting average. Christian Yelich leads the team in RBI, with 102, adding a team-high 29 home runs.

Chad Patrick (R) is the projected starting pitcher for the Brewers, and he has a 3-8 record, 3.66 ERA and 1.28 WHIP.

Milwaukee Brewers @ San Diego Padres Betting Trends: September 24, 2025

• Probable Starting Pitcher: Dylan Cease      Record this season: 8-12      ERA: 4.64
• Home Record: 7-3
• Last 5 against Brewers: 1-1

Why the San Diego Padres will win

• The Brewers have lost each of their last six games against teams that held a winning record.
• The Padres have won eight of their last nine day games against NL Central opponents.
• The Padres have covered the run line in each of their last nine day games against NL Central opponents.
• The Brewers have failed to cover the run line in each of their last eight road games.
• The Padres have won the first inning in four of their last five home games.
• The Padres have led after 3 innings in each of their last four games as home favorites.
• The Brewers have trailed after 5 innings in seven of their last eight road games.

• Probable Starting Pitcher: Chad Patrick      Record this season: 3-8      ERA: 3.66
• Road Record: 1-4
• Last 5 against Padres: 0-1

Why the Milwaukee Brewers will win

• The Brewers have won each of their last six games as underdogs against NL West opponents.
• The Padres have lost four of their last five games as favorites against the Brewers following a home win.
• The Brewers have covered the run line in each of their last 11 games as underdogs following a loss.
• The Padres have failed to cover the run line in five of their last six games as favorites against NL Central opponents following a win.
• The Brewers have led after 5 innings in six of their last eight games against NL West opponents.
• The Padres have lost the first inning in each of their last three day games against National League opponents that held a winning record.
• The Brewers have led after 3 innings in three of their last four games at Petco Park against opponents that held a winning record.

Total Runs Facts

• Seven of the Brewers’ last eight games as underdogs against the Padres have gone OVER the total runs line.
• Each of the Padres’ last five games as favorites against the Brewers have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Padres’ last eight games against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 13 of the Brewers’ last 15 games as road underdogs.

San Diego Padres Player Prop Facts

• Jackson Merrill has hit a home run in three of the Padres’ last four games as home favorites.
• Dylan Cease has recorded six or more strikeouts in each of his last nine home appearances against NL opponents.
• Dylan Cease has recorded a win in each of his last four appearances with the Padres as favorites against NL opponents.
• Jose Iglesias has recorded at least one hit in each of his last 15 appearances in day games against NL Central teams that held a winning record.
• Luis Arraez ranks 4th in the league in Hits (175) this season.

Milwaukee Brewers Player Prop Facts

• Brice Turang has hit a home run in three of the Brewers’ last four day games against opponents that held a winning record.
• William Contreras has recorded at least one hit in each of his last 10 appearances with the Brewers as road underdogs against NL West opponents.

Matchup/League Facts

• The Padres rank 1st in the league for opponent batting average this season (.224).
• The Padres rank 1st in the league for hits allowed this season (1163).
• The Brewers rank 2nd in the league for hits this season (1396).
• The Brewers rank 2nd in the league for on-base percentage this season (.333).

Brewers vs Padres Prediction

The Padres are 9-3 in their last 12 head-to-head meetings against the Brewers, and are 5-1 in their last 6 meetings in San Diego. Under is 4-1 in their last 5 meetings.

In this Brewers vs Padres Prediction, the Padres are coming as -130 home favorites. Both teams have clinched their playoffs spot, but the Padres are in a better situation today, as Cease has been better at home, with a 3.72 home ERA, while Patrick has been weaker on the road for the Brewers, with a 4.56 road ERA. The Padres have the best bullpen in baseball to back Cease up, and have been hot lately, with four straight wins. Take the Padres to take care of business once again at home in this one.