Milwaukee Brewers vs San Diego Padres Prediction 9/23/2025 Today’s MLB Picks

The Milwaukee Brewers and San Diego Padres meet Tuesday in MLB action at Petco Park. Here’s a Milwaukee Brewers vs San Diego Padres Prediction. This article will include a Milwaukee Brewers vs San Diego Padres Pick.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 95-62 on the year and play the Reds next. The Milwaukee Brewers are batting .260 on the season, have a .334 OBP, and a .407 slugging percentage. The Milwaukee Brewers pitching staff has a 3.62 ERA and a 1.23 WHIP. Brice Turang leads the Milwaukee Brewers with 161 hits and 77 RBI, while Sal Frelick and William Contreras have combined for 296 hits and 138 RBI.

Bruce Zimmermann gets the ball for the Milwaukee Brewers, and he was 2-0 with a 4.73 ERA and 14 strikeouts in the 2023 season. This will be Zimmermann’s first career game against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 86-71 on the year and play the Diamondacks next. The San Diego Padres are batting .252 on the season, have a .320 OBP, and a .388 slugging percentage. The San Diego Padres pitching staff has a 3.68 ERA and a 1.21 WHIP. Luis Arraez leads the San Diego Padres with 172 hits and 58 RBI while Manny Machado and Fernando Tatis Jr. have combined for 321 hits and 159 RBI.

Randy Vasquez gets the ball for the San Diego Padres, and he is 5-7 with a 3.94 ERA and 74 strikeouts this season. Vasquez is 1-0 with a 0.00 ERA and 5 strikeouts in his career against the Milwaukee Brewers.

Milwaukee Brewers @ San Diego Padres Betting Trends: September 23, 2025

• Probable Starting Pitcher: Randy Vasquez      Record this season: 5-7      ERA: 3.94
• Home Record: 2-2
• Last 5 against Brewers: 1-0

Why the San Diego Padres will win

• The Brewers have lost each of their last five games against teams that held a winning record.
• The Padres have won four of their last five home games.
• The Brewers have failed to cover the run line in each of their last seven road games after playing the previous day.
• The Padres have covered the run line in each of their last four games against the Brewers.
• The Padres have led after 5 innings in six of their last eight games at Petco Park against opponents that held a winning record.

• Probable Starting Pitcher: TBD

Why the Milwaukee Brewers will win

• The Brewers have won eight of their last nine games against the Padres after going to extra innings.
• The Padres have lost four of their last five games against National League opponents following a home win.
• The Brewers have covered the run line in six of their last seven games against NL West opponents that held a winning record.
• The Padres have failed to cover the run line in four of their last five games following an extra innings win.
• The Padres have trailed after 3 innings in four of their last five night games.
• The Padres have trailed after 5 innings in four of their last five night games.

Total Runs Facts

• Each of the last five games between the Brewers and Padres at Petco Park have gone OVER the total runs line.
• Five of the Brewers’ last six road games after going to extra innings have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Padres’ last seven night games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 15 of the Brewers’ last 20 night games against NL West opponents.

San Diego Padres Player Prop Facts

• Manny Machado has hit a home run in two of his last three home appearances.
• Gavin Sheets has recorded at least one Double in three of the Padres’ last four games at Petco Park against opponents that held a winning record.
• Luis Arraez has recorded at least one hit in each of his last 10 appearances after playing the previous day.

Milwaukee Brewers Player Prop Facts

• William Contreras has hit a home run in four of his last 14 road appearances against NL West opponents.
• Brice Turang has recorded at least one hit in each of the Brewers’ last eight night games against NL opponents that held a winning record.

Matchup/League Facts

• The Padres rank 29th in the league for home runs this season (142).
• The Padres rank 2nd in the league for runs allowed this season (605).
• The Brewers rank 2nd in the league for on-base percentage this season (.334).
• The Brewers rank 2nd in the league for steals this season (159).

Milwaukee Brewers vs San Diego Padres Prediction

The Brewers are still playing for the best record in the bigs, but they’re coming off some tough losses. Now, they’re throwing out Zimmermann, who hasn’t pitched since 2023 due to injuries and inconsistent performances. In MLB starts from 2021-2022, Zimmermann has a 5.54 ERA and 5.74 FIP. No, thanks. The Padres have caught a recent heat wave, and they’re still in the NL West race. Vasquez is having a decent September where he’s allowed 16 hits and 6 earned runs in 14.1 innings, and he has a 3.41 ERA and .246 allowed batting average in 63.1 home innings. Give me the Padres.