Apr 24, 2026; St. Louis, Missouri, USA; Seattle Mariners starting pitcher George Kirby (68) pitches against the St. Louis Cardinals during the first inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images
Jeff Curry-Imagn Images

Mariners vs Twins Prediction 4/29/2026 Today’s MLB Picks

Pick details

MATCHUP Seattle Mariners Minnesota Twins
Team Records 15-16 13-17
Spread -1.5 123 +1.5 -149
Moneyline -131 +109
Total Over 8 (-102) Under 8 (-118)
Where Target Field, Minneapolis, Minnesota
When Wednesday, April 29, 2026
Time 01:40 PM EDT
TV MLB.TV

In this article we will formulate a Mariners vs Twins prediction for this MLB game on Wednesday, April 29th at Target Field in Minneapolis, Minnesota. Let’s take a look at the prediction for this MLB matchup. 

Seattle Mariners Betting Preview

The Seattle Mariners are 15-16 this season after they split the first two games in this series by scores of 4-11 and 7-1. In game two, Seattle trailed 1-0 in the fifth inning, but they scored the last seven runs for the lopsided win. The Mariners recorded 12 hits and they committed one error in the game, while they were led by Naylor, who went 3-5 with one home run and four RBIs. Gilbert allowed six hits and one earned run over 5.0 innings, while Bazardo got the win and Speier picked up the hold. Prior to this series, Seattle swept the Cardinals in three games, but lost two out of three against the Athletics before that. 

This season, Seattle has a 3.69 ERA with a 1.25 WHIP and a .258 opponent batting average, while they have scored 129 runs with a .235 batting average and a .324 on base percentage. Cal Raleigh has led the Mariners with seven home runs and 17 RBIs, while Cole Young has added three home runs and 16 RBIs. The projected starting pitcher for Seattle is George Kirby, who is 4-2 with a 2.97 ERA and a 1.04 WHIP over 39.1 innings pitched this season. 

Minnesota Twins Betting Preview

The Minnesota Twins are 13-17 this year after they lost game two by a score of 7-1 on Tuesday night. Minnesota took a 1-0 lead in the fifth inning, but they couldn’t find anymore offense for the loss. The Twins recorded seven hits in the game and they were led by Buxton, who went 2-5 with one home run and one RBI. Ryan allowed six hits and two earned runs over 6.0 innings for the loss, while Sands allowed two earned runs in relief. Prior to this series, Minnesota lost all three against the Rays and two out of three against the Mets. 

This season, Minnesota has a 4.40 ERA with a 1.37 WHIP and a .253 opponent batting average, while they have scored 144 runs with a .229 batting average and a .326 on base percentage. Ryan Jeffers has led the Twins with three home runs and 18 RBIs, while Josh Bell has added three home runs and 16 RBIs. The projected starting pitcher for Minnesota is Taj Bradley, who is 3-1 with a 2.91 ERA and a 1.29 WHIP over 34.0 innings pitched this year. 

Why the Minnesota Twins will win

  • The Mariners have lost each of their last four games as favorites against American League opponents following a road win.
  • The Twins have won six of their last eight games as home underdogs.
  • The Mariners have failed to cover the run line in each of their last 10 Wednesday day games.
  • The Twins have covered the run line in 17 of their last 19 games as underdogs against AL West opponents following a loss.
  • The Mariners have trailed after 5 innings in each of their last four road games against American League opponents.
  • The Mariners have trailed after 3 innings in three of their last four games.

Why the Seattle Mariners will win

  • The Mariners have won each of their last five day games against American League opponents.
  • The Twins have lost each of their last five day games after playing the previous day.
  • The Twins have failed to cover the run line in each of their last six Wednesday day games at Target Field.
  • The Mariners have covered the run line in five of their last six day games against teams that held a losing record.
  • The Twins have trailed after 5 innings in each of their last three day games against American League opponents.

Total Runs Facts

  • Each of the Twins’ last five home games after playing the previous day have gone OVER the total runs line.
  • Each of the Mariners’ last four games as favorites against the Twins have gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last eight games between the Mariners and Twins.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Mariners’ last nine road games.

Mariners vs Twins Prediction 

Seattle was able to bounce back from that ugly loss in game one with a big win in game two, and they have won five of their last six games. The Mariners are 5-9 on the road this year, while the Twins are 8-7 at home. Minnesota has lost 10 of their last 12 games and they have scored two runs or fewer in four of their last five. The Twins are starting Bradley, who has allowed two earned runs or fewer in four of his last five starts, while Kirby has allowed two earned runs or fewer in three straight outings. I think Kirby is the much better pitcher in this game, so I like the Mariners to win here.

David Racey's Pick: Mariners ML

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