New York Yankees vs Minnesota Twins Prediction 9/16/2026 Today’s MLB Picks

In this article, we will formulate a Yankees vs Twins Prediction for this MLB matchup on Wednesday, September 16th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Minnesota Twins Preview

The Minnesota Twins have a 70-81 record this season and are sitting in the 4th place of the AL Central. They have a 39-38 home record and are coming off a 1-8 home loss against the Yankees. They will face the Angels and the Giants next.

The Minnesota Twins have a .243 batting average this season, .317 OBP and .404 Slugging percentage. Minnesota’s pitching staff has a 4.70 ERA and 1.38 WHIP. Luke Keaschall is the team’s best hitter with a .276 batting average. Josh Bell leads the team in RBI with 87, while Kody Clemens adds a team-high 26 home runs.

Zebby Matthews (R) is the projected starting pitcher for the Twins, and he has a 9-10 record, 4.98 ERA and 1.27 WHIP.

New York Yankees Preview

The New York Yankees have a 88-63 record this season and are sitting in the 2nd place of the AL East. They have a 46-31 away record and are coming off an 8-1 road win against the Twins. They will face the Dbacks and the Rays next.

The New York Yankees have a .236 batting average this season, .312 OBP and .411 Slugging percentage. New York’s pitching staff has a 3.21 ERA and 1.16 WHIP. Cody Bellinger is the team’s best hitter with a .272 batting average. Ben Rice leads the team in RBI with 92, adding a team-high 38 home runs.

Carlos Rodon (L) is the projected starting pitcher for the Yankees, and he has a 6-3 record, 2.94 ERA and 1.12 WHIP.

New York Yankees @ Minnesota Twins Betting Trends: September 16, 2026

• Probable Starting Pitcher: Zebby Matthews      Record this season: 9-10      ERA: 4.98
• Home Record: 5-4
• Last 5 against Yankees: 0-2

Why the Minnesota Twins will win

• The Twins have won each of their last six day games against AL East opponents.
• The Yankees have lost each of their last four day games against AL Central opponents.
• The Twins have covered the run line in each of their last six day games against AL East opponents.
• The Yankees have failed to cover the run line each of their last four day games against AL Central opponents that held a losing record.
• The Twins have led after 3 innings in each of their last seven day games against AL East opponents.
• The Twins have won the first inning in six of their last seven day games against AL East opponents.
• The Twins have led after 5 innings in six of their last seven day games against AL East opponents.

• Probable Starting Pitcher: Carlos Rodon      Record this season: 6-3      ERA: 2.94
• Road Record: 4-1
• Last 5 against Twins: 4-1

Why the New York Yankees will win

• The Yankees have won nine of their last 10 games against teams that held a losing record.
• The Twins have lost each of their last four home games against AL East opponents that held a winning record.
• The Twins have failed to cover the run line in each of their last six games.
• The Yankees have covered the run line in each of their last six road games after playing the previous day.
• The Yankees have led after 5 innings in nine of their last 10 games against opponents that held a losing record.
• The Yankees have led after 3 innings in each of their last four games as favorites against AL Central opponents.
• The Yankees have won the first inning in three of their last four games at Target Field.

Total Runs Facts

• Each of the Yankees’ last seven games against AL opponents have gone OVER the total runs line.
• Each of the last four games between the Yankees and Twins at Target Field have gone OVER the total runs line.
• There has been at least one run scored in the first inning in each of Zebby Matthews’ last eight appearances as a starter.
• There has been no run scored during the first inning in each of Carlos Rodon’s last four road appearances as a starter.

Minnesota Twins Player Prop Facts

• Josh Bell has hit a home run in three of his last four home appearances against AL East opponents that held a winning record.
• Zebby Matthews has recorded a win in each of his last three home appearances.
• Zebby Matthews has recorded five or more strikeouts in 10 of his last 13 appearances against AL opponents that held a winning record.
• Kody Clemens has recorded at least one hit in each of the Twins’ last 10 Wednesday games.

New York Yankees Player Prop Facts

• Austin Wells has hit a home run in each of his last two appearances.
• Carlos Rodon has recorded a win in eight of his last 10 appearances with his team as a favorite against the Twins .
• Cody Bellinger has recorded at least one hit in each of his last 12 road appearances after playing the previous day.
• Luis Garcia ranks 3rd amongst qualified players for Slugging Percentage (.543) this season.

Matchup/League Facts

• The Twins rank 26th in the league for ERA this season (4.70).
• The Twins rank 26th in the league for runs allowed this season (761).
• The Yankees rank 1st in the league for home runs this season (209).
• The Yankees rank 1st in the league for ERA this season (3.21).

Yankees vs Twins Prediction

The Yankees are 5-2 in their last 7 meetings against the Twins and have won their last four visits in Minnesota. 

In this Yankees vs Twins Prediction, the Yankees are coming as -170 road favorites. I like the Yankees to keep rolling in this one, as they have the pitching edge with Carlos Rodon on the mound. He has given up one run or less in five of his last six starts, while Matthews has given up 9 runs in his last two starts and has been bad against the Yankees historically. The Twins cannot hit lefties lately and their bullpen has been terrible, so take the Yankees to win this one on the road.

Nikos Lagouretos's Pick: New York Yankees ML