Los Angeles Dodgers vs St. Louis Cardinals Prediction 6/6/25 MLB Picks

In this article, we will formulate a Dodgers vs Cardinals prediction for this MLB game on Friday, June 6, at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Dodgers Betting Preview

The Los Angeles Dodgers (38-25, 15-14 Away) spent the last two series at home, where they faced both teams from New York. Following a win over the Yankees, the Dodgers split the series with the Mets. Los Angeles salvaged that series with a 6-5 victory in Game 4, scoring three runs in the 8th inning to come from behind and secure a W. Will Smith led the offense with two RBI, while Landon Knack pitched for 3.1 innings in a no-decision, allowing four runs on four hits with one strikeout and five walks. Alex Vesia was credited with the win. 

This year, the Dodgers average 5.70 runs per game (2nd in the MLB) on a .266/.341/.465 triple-slash. When it comes to pitching, the Dodgers’ staff has a 4.13 ERA (21st) and 1.30 WHIP (17th). Teoscar Hernandez leads the Dodgers with a .272 batting average, ten home runs, and 43 RBI this season.

The projected starting pitcher for the Dodgers is Justin Wrobleski, who is 1-1 in one start this season, with an 8.00 ERA and 1.33 WHIP in 9.0 innings.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals (34-28, 20-10 Home) are not in fine form at the moment after losing back-to-back series to the Texas Rangers and Kansas City Royals. In the latest 7-5 defeat in Game 3 against the Royals, Willson Contreras led the offense with three RBI, while Matthew Liberatore took the loss after allowing seven runs on eight hits with two strikeouts and one walk in 4.0 innings. 

This season, the Cardinals average 4.69 runs per game (8th in the MLB) on a .257/.329/.395 triple-slash. When it comes to pitching, the Cardinals’ staff has a 3.93 ERA (16th) and 1.25 WHIP (15th). Willson Contreras leads the Cardinals with a .250 batting average, six home runs, and 36 RBI this season.

Sonny Gray will take the mound for the Cardinals on Friday. The 35-year-old right-hander has a 6-1 record in 12 starts this year with a 3.65 ERA and 1.12 WHIP in 69.0 innings.

Why the Cardinals will beat the Dodgers

• The Cardinals have won 12 of their last 13 games as home underdogs following a home loss.
• The Dodgers have lost four of their last five games as road favorites against NL Central opponents following a home win.
• The underdogs have covered the run line in each of the Dodgers’ last eight games.
• The Dodgers have failed to cover the run line in each of their last six games as favorites.
• The Cardinals have led after 5 innings in four of their last five night games against the Dodgers at Busch Stadium.
• The Cardinals have led after 3 innings in four of their last five games against the Dodgers at Busch Stadium.

Total Runs Facts

• Each of the Cardinals’ last four night games after playing the previous day have gone OVER the total runs line.
• Four of the Dodgers’ last five games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last five games at Busch Stadium.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Dodgers’ last four games as favorites against NL Central opponents.

Matchup/League Facts

• The Cardinals rank 3rd in the league for home runs allowed this season (50).
• The Cardinals rank 4th in the league for doubles this season (114).
• The Dodgers rank 1st in the league for home runs this season (101).
• The Dodgers rank 1st in the league for batting average this season (.266).

Dodgers vs Cardinals Prediction

The Dodgers won six of the previous ten H2H encounters, including five of the last seven. However, I am backing the Cardinals in this one, mainly because of the pitching matchup. Justin Wrobleski is an emergency starter for the Dodgers, who have numerous pitchers on IL, and I don’t think he will have a good time in St. Louis. Sonny Gray, on the other hand, allowed just three runs in his last three starts, all of which were quality starts. In two of those, Gray posted shutouts. His numbers and experience make me to back the Cardinals.