Sep 12, 2025; San Francisco, California, USA; Los Angeles Dodgers designated hitter Shohei Ohtani (17) places his bat on the ground before batting against the San Francisco Giants during the fifth inning at Oracle Park. Mandatory Credit: Darren Yamashita-Imagn Images

Los Angeles Dodgers vs San Francisco Giants Prediction 9/14/2025 Today’s MLB Picks

Pick details

Los Angeles (83-65) vs San Francisco (75-73)

September 14, 2025 at 04:05 PM EDT

The Line: Betting Odds: San Francisco +115 — Over/Under: +8

(Get latest betting odds)

The Los Angeles Dodgers and the San Francisco Giants meet Sunday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Dodgers vs. San Francisco Giants prediction.

Starting Pitching Matchup

The Los Angeles Dodgers will send out Tyler Glasnow for the start here and Glasnow is 2-3 with a 3.21 ERA and 92 strikeouts this season. In his last five starts agains the Giants, Glasnow is 3-1 with a 3.81 ERA and 25 strikeouts. Robbie Ray will get the nod for the Giants here and is 11-6 with a 3.32 ERA and 176 strikeouts this season. In his last five starts against the Dodgers, Ray is 2-1 with a 4.73 ERA and 31 strikeouts.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to build on their 13-7 win over the Giants on Saturday’s matchup to sit at 83-65 this season. After this series, the Dodgers will head home for a set against the Philadelphia Phillies.

Dodgers Win 5 Of Their Last 6 Games

Shohei Ohtani has 152 hits including 21 doubles, 48 home runs, 90 RBIs and 8 triples . Michael Conforto has 73 hits with 20 doubles while Teoscar Hernandez has 107 hits with 21 home runs, 25 doubles and 78 RBIs as well this season. Ohtani has a team-high 17 stolen bases while Max Muncy has 10 doubles but also has 73 strikeouts so far this season. Mookie Betts has also chipped in 16 home runs and 67 RBIs as well on the year. Freddie Freeman has also logged 144 hits with a team-high 37 doubles, 19 home runs and 78 RBIs. Andy Pages also has 139 hits with 22 doubles, 24 home runs and 79 RBIs as well this season.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to rebound from their loss at the hands of the Dodgers to fall to 75-73 on the year. After this series, the Giants will head on the road for a series against the Diamondbacks. 

Giants Looking To Bounce Back

Jung Hoo Lee has 139 hits including a team-high 30 doubles along with 11 triples, 8 home runs and 51 RBIs with 10 stolen bases while Heliot Ramos has 146 hits with 23 doubles, 17 home runs and 61 RBIs. Wilmer Flores also 15 home runs and 67 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 96 hits with 21 home runs and 56 RBIs along with 19 doubles and Willy Adames has 122 hits with 19 doubles, 28 home runs and 81 RBIs of his own this season. 

Los Angeles Dodgers @ San Francisco Giants Betting Trends: September 14, 2025

  • Probable Starting Pitcher: Robbie Ray      Record this season: 11-6      ERA: 3.32
  • Home Record: 5-3
  • Last 5 against Dodgers: 2-1

Why the San Francisco Giants will win

  • The Dodgers have lost each of their last seven games as road favorites following a win.
  • The Giants have won six of their last seven games as underdogs against National League opponents.
  • The Dodgers have failed to cover the run line in each of their last nine road games following a win.
  • The Giants have covered the run line in each of their last eight games as underdogs against National League opponents.
  • The Dodgers have trailed after 5 innings in each of their last four games as road favorites against NL West opponents.
  • The Giants have won the first inning in each of their last four games against opponents that held a winning record.
  • The Dodgers have trailed after 3 innings in each of their last six road games against National League opponents.
  • Probable Starting Pitcher: Tyler Glasnow      Record this season: 2-3      ERA: 3.21
  • Road Record: 0-1
  • Last 5 against Giants: 3-1

Why the Los Angeles Dodgers will win

  • The Dodgers have won each of their last 13 day games against NL West opponents.
  • The Giants have lost eight of their last nine day games against NL West opponents that held a winning record.
  • The Giants have failed to cover the run line in 13 of their last 14 home games against National League opponents following a home loss.
  • The Dodgers have covered the run line in each of their last five games after playing the previous day.
  • The Giants have trailed after 5 innings in seven of their last eight day games against NL West opponents that held a winning record.
  • The Dodgers have won the first inning in each of their last six day games.
  • The Dodgers have led after 3 innings in six of their last seven day games.

Total Runs Facts

  • Each of the Giants’ last five day games against National League opponents have gone UNDER the total runs line.
  • Each of the Dodgers’ last four games as road favorites have gone UNDER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Dodgers’ last six day games.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Giants’ last 10 home games.

San Francisco Giants Player Prop Facts

  • Matt Chapman has hit at least one home run in three of his last four appearances with the Giants as home underdogs against NL opponents.
  • Patrick Bailey has recorded at least one hit in each of the Giants’ last eight home games against the Dodgers.
  • Rafael Devers ranks 9th amongst qualified players for On Base Percentage (.378) this season.

Los Angeles Dodgers Player Prop Facts

  • Freddie Freeman has hit at least one home run in each of the Dodgers’ last three day games against opponents that held a winning record.
  • Freddie Freeman has recorded a Double in three of the Dodgers’ last four games against the Giants.
  • Tyler Glasnow has recorded seven or more strikeouts in six of his last seven appearances against NL West opponents that held a winning record.
  • Andy Pages has recorded at least one hit in each of the Dodgers’ last eight day games against NL opponents that held a winning record.
  • Shohei Ohtani ranks 2nd amongst qualified players for Slugging Percentage (.612) this season.

Matchup/League Facts

  • The Giants rank 1st in the league for home runs allowed this season (127).
  • The Giants rank 29th in the league for steals this season (64).
  • The Dodgers rank 2nd in the league for home runs this season (217).
  • The Dodgers rank 2nd in the league for RBIs this season (721).

Los Angeles Dodgers vs. San Francisco Giants Prediction

I’m backing the Giants here. I just think it’s where the value is as I think Glasnow is hittable and the Giants have still been doing a really good job of hitting right-handed pitching as of late. Robbie Ray’s been solid at home, and I think the Dodgers could have some issues against him here. I’ll side with the Giants in this one.

Chris Ruffolo's Pick: San Francisco +115

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