Los Angeles Dodgers vs San Francisco Giants Prediction 9/12/2025 Today’s MLB Picks

The Los Angeles Dodgers and the San Francisco Giants meet Friday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Dodgers vs. San Francisco Giants prediction.

Starting Pitching Matchup

The Los Angeles Dodgers will send out Yoshinobu Yamamoto here and Yamamoto is 11-8 with a 2.72 ERA and 177 strikeouts this season. In his career, Yamamoto is 0-1 with a 4.67 ERA and 17 strikeouts against the Giants. Justin Verlander will get the start for the Giants and is 3-10 with a 4.09 ERA and 120 strikeouts this season. In his career, Verlander is 3-1 with a 3.38 ERA and 33 strikeouts against the Dodgers.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to add on to their 9-0 win over the Colorado Rockies last time out to sit at 82-64 this season. After this series, the Dodgers will head home for a series against the Philadelphia Phillies.

Dodgers Win Four In A Row

Shohei Ohtani has 152 hits including 21 doubles, 48 home runs, 90 RBIs and 8 triples . Michael Conforto has 73 hits with 20 doubles while Teoscar Hernandez has 107 hits with 21 home runs, 25 doubles and 78 RBIs as well this season. Ohtani has a team-high 17 stolen bases while Max Muncy has 10 doubles but also has 73 strikeouts so far this season. Mookie Betts has also chipped in 16 home runs and 67 RBIs as well on the year. Freddie Freeman has also logged 144 hits with a team-high 37 doubles, 19 home runs and 78 RBIs. Andy Pages also has 139 hits with 22 doubles, 24 home runs and 79 RBIs as well this season.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to bounce back from a 5-3 loss at the hands of the Arizona Diamondbacks last time out to sit at 74-72 on the year. After this series, the Giants will head on the road for a rematch series against the Diamondbacks. 

Giants Looking To Rebound After Failing To Complete Sweep

Jung Hoo Lee has 139 hits including a team-high 30 doubles along with 11 triples, 8 home runs and 51 RBIs with 10 stolen bases while Heliot Ramos has 146 hits with 23 doubles, 17 home runs and 61 RBIs. Wilmer Flores also 15 home runs and 67 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 96 hits with 21 home runs and 56 RBIs along with 19 doubles and Willy Adames has 122 hits with 19 doubles, 28 home runs and 81 RBIs of his own this season. 

Los Angeles Dodgers @ San Francisco Giants Betting Trends: September 12, 2025

• Probable Starting Pitcher: Justin Verlander      Record this season: 3-10      ERA: 4.09
• Home Record: 2-6
• Last 5 against Dodgers: 2-2

Why the San Francisco Giants will win

• The Dodgers have lost each of their last six games as road favorites following a win.
• The Giants have won five of their last six games as underdogs against National League opponents.
• The Dodgers have failed to cover the run line in each of their last eight road games following a win.
• The Giants have covered the run line in each of their last seven games as underdogs against National League opponents.
• The Giants have won the first inning in each of their last five Friday games.
• The Dodgers have trailed after 5 innings in five of their last six road games against National League opponents.
• The Dodgers have trailed after 3 innings in each of their last four road games against National League opponents.

• Probable Starting Pitcher: Yoshinobu Yamamoto      Record this season: 11-8      ERA: 2.72
• Road Record: 8-4
• Last 5 against Giants: 0-1

Why the Los Angeles Dodgers will win

• The Giants have lost each of their last 10 home games against National League opponents following a home loss.
• The Dodgers have won seven of their last eight games against the Giants following a home win.
• The Giants have failed to cover the run line in each of their last 13 home games against National League opponents following a home loss.
• The Dodgers have covered the run line in each of their last four games.
• The Dodgers have led after 3 innings in four of their last five games.
• The Giants have trailed after 5 innings in each of their last five games as home underdogs against NL West opponents.

Total Runs Facts

• Each of the Giants’ last five night games against NL West opponents have gone OVER the total runs line.
• Four of the Dodgers’ last five road games have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Dodgers’ last eight night games against NL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Giants’ last eight home games.

San Francisco Giants Player Prop Facts

• Matt Chapman has hit at least one home run in each of his last three appearances with the Giants as home underdogs against NL opponents.
• Justin Verlander has recorded five or more strikeouts in each of his last eight home appearances.
• Jung Hoo Lee has recorded at least one hit in each of his last 12 appearances after not playing the previous day.
• Rafael Devers ranks 9th amongst qualified players for On Base Percentage (.378) this season.

Los Angeles Dodgers Player Prop Facts

• Mookie Betts has hit a home run in three of the Dodgers’ last four games.
• Freddie Freeman has recorded at least one Double in three of the Dodgers’ last four games as road favorites against the Giants.
• Miguel Rojas has recorded at least one hit in each of his last seven appearances against the Giants after not playing the previous day.
• Shohei Ohtani ranks 2nd amongst qualified players for Slugging Percentage (.609) this season.

Matchup/League Facts

• The Giants rank 1st in the league for home runs allowed this season (125).
• The Giants rank 29th in the league for steals this season (64).
• The Dodgers rank 2nd in the league for home runs this season (215).
• The Dodgers rank 2nd in the league for RBIs this season (708).

Los Angeles Dodgers vs. San Francisco Giants Prediction

I’m leaning towards the Dodgers here. I just think that the Dodgers get it done here, because as well as Justin Verlander has pitched, the Giants have still had a hard time winning games with him on the mound. Yamamoto’s on a roll right now and I just don’t feel like stepping in front of him here. Give me the Dodgers in this one.