Los Angeles Angels vs Seattle Mariners Prediction 9/12/2025 Today’s MLB Picks

The Los Angeles Angels and Seattle Mariners meet Friday in MLB action at T-Mobile Park. Here’s a Los Angeles Angels vs Seattle Mariners Prediction. This article will include a Los Angeles Angels vs Seattle Mariners Pick.

Los Angeles Angels Betting Preview

The Los Angeles Angels are 69-78 on the year and play the Brewers, Rockies, and Royals next. The Los Angeles Angels are batting .229 on the season, have a .304 OBP, and a .402 slugging percentage. The Los Angeles Angels pitching staff has a 4.79 ERA and a 1.43 WHIP. Zach Neto leads the Los Angeles Angels with 129 hits and 62 RBI, while Nolan Schanuel and Taylor Ward have combined for 243 hits and 146 RBI.

Yusei Kikuchi gets the ball for the Los Angeles Angels, and he is 6-11 with a 4.18 ERA and 163 strikeouts this season. Kikuchi is 1-2 with a 1.29 ERA and 35 strikeouts in his career against the Seattle Mariners.

Seattle Mariners Betting Preview

The Seattle Mariners are 79-68 on the year and play the Royals, Astros, and Rockies next. The Seattle Mariners are batting .243 on the season, have a .319 OBP, and a .414 slugging percentage. The Seattle Mariners pitching staff has a 3.95 ERA and a 1.25 WHIP. Julio Rodriguez leads the Seattle Mariners with 161 hits and 89 RBI while JP Crawford and Randy Arozarena have combined for 274 hits and 123 RBI.

Luis Castillo gets the ball for the Seattle Mariners, and he is 9-8 with a 3.85 ERA and 144 strikeouts this season. Castillo is 5-2 with a 2.97 ERA and 75 strikeouts in his career against the Los Angeles Angels.

Los Angeles Angels @ Seattle Mariners Betting Trends: September 12, 2025

• Probable Starting Pitcher: Luis Castillo      Record this season: 9-8      ERA: 3.85
• Home Record: 4-4
• Last 5 against Angels: 3-1

Why the Seattle Mariners will win

• The Mariners have won 14 of their last 15 games at T-Mobile Park against teams that held a losing record.
• The Angels have lost each of their last six games at T-Mobile Park following a loss.
• The Mariners have covered the run line in five of their last six games after playing the previous day.
• The Angels have failed to cover the run line in each of their last four games at T-Mobile Park following a loss.
• The Angels have trailed after 3 innings in five of their last six games at T-Mobile Park.

• Probable Starting Pitcher: Yusei Kikuchi      Record this season: 6-11      ERA: 4.18
• Road Record: 1-8
• Last 5 against Mariners: 1-2

Why the Los Angeles Angels will win

• The Angels have won each of their last four games as underdogs against American League opponents following a loss.
• The Mariners have lost six of their last eight games as favorites against AL West opponents following a win.
• The Mariners have failed to cover the run line in each of their last nine games against AL West opponents following a win.
• The Angels have covered the run line in each of their last seven games as road underdogs following an extra innings loss.
• The Angels have led after 3 innings in three of their last four games as underdogs against American League opponents.

Total Runs Facts

• Seven of the Mariners’ last eight night games against AL West opponents have gone UNDER the total runs line.
• Each of the Angels’ last five night games after playing the previous day have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Angels’ last eight games as road underdogs.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Mariners’ last 10 games as home favorites against AL West opponents.

Seattle Mariners Player Prop Facts

• Jorge Polanco has recorded at least one Double in each of the Mariners’ last five games at T-Mobile Park.
• Cal Raleigh has hit at least one home run in three of his last five appearances against the Angels after playing the previous day.
• Luis Castillo has recorded a win in three of his four previous appearances against the Angels at T-Mobile Park.
• Jorge Polanco has recorded at least one hit in each of the Mariners’ last eight home games.
• Cal Raleigh ranks 3rd amongst qualified players for Slugging Percentage (.570) this season.

Los Angeles Angels Player Prop Facts

• Yoan Moncada has recorded a Double in each of the Angels’ last three games as road underdogs.
• Jo Adell has hit a home run in four of his last five appearances with the Angels as underdogs against AL opponents.
• Yusei Kikuchi has recorded seven or more strikeouts in three of his last four road appearances against opponents that held a winning record.
• Mike Trout has recorded at least one hit in each of his last nine appearances at T-Mobile Park.

Matchup/League Facts

• The Mariners rank 3rd in the league for home runs this season (213).
• The Mariners rank 28th in the league for strikeouts against this season (1303).
• The Angels rank 30th in the league for walks allowed this season (568).
• The Angels rank 29th in the league for hits this season (1123).

Los Angeles Angels vs Seattle Mariners Prediction

It’s hard to find confidence in teams like the Angels this time of year, and Kikuchi has allowed 14 hits and 12 runs in his last 7.2 innings. Kikuchi has allowed 18 runs in his last 11.2 innings. In 77.2 road innings, Kikuchi has a 5.45 ERA and .289 allowed batting average. No, thanks. The Mariners are making their playoff push with a strong week, and Castillo has been great at home with his 2.79 ERA and .206 allowed batting average in 87 innings. The Mariners need to take advantage of series like this to inch closer to the postseason. Give me the M’s at home.