Los Angeles Angels vs Milwaukee Brewers Prediction 9/16/2025 Today’s MLB Picks

In this article, we will formulate an Angels vs Brewers Prediction for this MLB game on Tuesday, September 16th at the American Family Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 91-59 record this season and are sitting on the first place of the NL Central. They have a 48-27 home record and are 72-73 in over/under. They are coming off a 2-3 home defeat by the Cardinals, that ended their two-game winning streak. Over is 5-2 in their last 7 games and are playing the Cardinals and the Padres next.

The Brewers have a .260 batting average this season, .333 OBP and .408 Slugging percentage. Milwaukee’s pitching staff has a 3.63 ERA and 1.24 WHIP. Brice Turang leads the Brewers with 156 hits, while Christian Yelich leads the team in RBI, with 96, adding a team-high 28 home runs. Sal Frelick is the team’s best hitter with a .295 batting average.

Freddy Peralta (R) is the projected starting pitcher for the Brewers, and he has a 16-6 record, 2.69 ERA and 1.09 WHIP.

Los Angeles Angels Preview

The Los Angeles Angels have a 69-81 record this season and are sitting on the 4th place of the AL West. The Angels have a 32-43 road record and 82-65 in over/under They are coming off a 2-11 road defeat by the Mariners, and have four consecutive losses. Over is 7-3 in their last 10 games and are playing the Rockies and the Royals next.

The Angels have a .228 batting average this season, .302 OBP and .399 Slugging percentage. LA’s pitching staff has a 4.83 ERA and 1.44 WHIP. Zach Neto leads the Angels with 129 hits, while Nolan Schanuel is the team’s best hitter with a .266 batting average. Taylor Ward leads the team with 98 RBI, while Jo Adell adds a team-high 36 home runs.

Caden Dana (R) is the projected starting pitcher for the Angels, and he has a 0-1 record, 6.32 ERA and 1.60 WHIP.

Los Angeles Angels @ Milwaukee Brewers Betting Trends: September 16, 2025

• Probable Starting Pitcher: Freddy Peralta      Record this season: 16-6      ERA: 2.69
• Home Record: 8-1
• Last 5 against Angels: 1-0

Why the Milwaukee Brewers will win

• The Brewers have won each of their last 11 Tuesday home games.
• The Angels have lost each of their last five road games.
• The Brewers have covered the run line in eight of their last nine night games following a home loss.
• The Angels have failed to cover the run line in seven of their last eight night games against NL Central opponents.
• The Brewers have led after 3 innings in seven of their last eight games against AL West opponents that held a losing record.
• The Angels have trailed after 5 innings in each of their last six games as underdogs against National League opponents.

• Probable Starting Pitcher: Caden Dana      Record this season: 0-1      ERA: 6.32
• Road Record: 0-0
• Last 5 against Brewers: –

Why the Los Angeles Angels will win

• The Brewers have lost each of their last four games as favorites against American League opponents.
• The Angels have won 12 of their last 16 games as road underdogs against National League opponents following a loss.
• The underdogs have covered the run line in eight of the Brewers’ last nine games at American Family Field.
• The Brewers have failed to cover the run line in each of their last five games as favorites against American League opponents.
• The Brewers have trailed after 3 innings in four of their last five games.
• The Brewers have trailed after 5 innings in each of their last five games as favorites against American League opponents.

Total Runs Facts

• Six of the Brewers’ last seven night games against AL West opponents have gone UNDER the total runs line.
• Four of the Angels’ last five games as underdogs have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Brewers’ last nine night games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Angels’ last nine games as underdogs against National League opponents.

Milwaukee Brewers Player Prop Facts

• Christian Yelich has hit at least one home run in three of his last four appearances after not playing the previous day.
• Freddy Peralta has recorded a win in seven of his last eight appearances in night games.
• Sal Frelick has recorded at least one hit in each of his last 10 appearances with the Brewers as home favorites against AL opponents.
• Rhys Hoskins has recorded a Double in each of the Brewers’ last three home games against AL West opponents.
• Freddy Peralta ranks T2nd in the league for Wins (16) this season.

Los Angeles Angels Player Prop Facts

• Mike Trout has recorded at least one hit in each of his last 10 Tuesday appearances with the Angels as underdogs.
• Travis d’Arnaud has hit at least one home run in each of his last two road appearances against the Brewers.
• Jo Adell ranks 8th in the league in Home Runs (36) this season.

Matchup/League Facts

• The Brewers rank 2nd in the league for on-base percentage this season (.333).
• The Brewers rank T2nd in the league for steals this season (153).
• The Angels rank 30th in the league for doubles this season (202).
• The Angels rank 30th in the league for strikeouts against this season (1496).

Angels vs Brewers Prediction

The Brewers are 4-2 in their last 6 meetings against the Angels, but both teams are tied 2-2 wins in their last 4 meetings Milwaukee. Under is 5-1-1 in their last 7 meetings.

In this Angels vs Brewers Prediction, the Brewers are coming as -210 home favorites. The Brewers have a huge pitching advantage in this matchup, as their best pitcher takes the mound, in Freddy Peralta, who has been elite at home, with a 1.72 ERA. Dana is coming off a terrible start, having given up 5 runs to the Twins, and the Angels have the third-worst bullpen ERA in baseball. Milwaukee has the third-best offense in baseball, and I expect them to dominate this game and cover the runline.