Kansas City Royals vs Oakland Athletics Prediction 9/26/2025 Today’s MLB Picks

In this article, we will formulate a Royals vs Athletics Prediction for this MLB game on Friday, September 26th at the Sutter Health Park in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Athletics Preview

The Athletics have a 75-84 record this season and are sitting on the last place of the AL West. The Athletics have a 35-43 home record and are 77-75 in over/under. They are coming off a 5-11 home defeat the Astros, that ended their two-game winning streak. Under is 6-3-1 in their last 10 games.

The Athletics have a .254 batting average this season, .318 OBP and .433 Slugging percentage. Athletics’ pitching staff has a 4.70 ERA and 1.36 WHIP. Brent Rooker leads the Athletics with 163 hits, while Jacob Wilson is the team’s best hitter with a .313 batting average. Tyler Soderstrom adds a team-high 93 RBI, while Nick Kurtz adds a team-high 35 home runs. 

The Athletics have not announced a starting pitcher for this matchup.

Kansas City Royals Preview

The Kansas City Royals have an 80-79 record this season and are sitting on the second place of the AL Central. The Royals have a 37-41 road record and are 70-88 in over/under. They are coming off a 9-4 road victory over the Angels, and are 4-2 in their last 6 games. Over is 7-3 in their last 10 games.

The Royals have a .247 batting average this season, .309 OBP and .396 Slugging percentage. Kansas’ pitching staff has a 3.75 ERA and 1.24 WHIP. Bobby Witt Jr. leads the Royals with 180 hits, and he is the team’s best hitter with a .296 batting average. Vinnie Pasquantino leads the team in RBI, with 111, and a team-high 32 home runs.

Noah Cameron (L) is the projected starter for the Royals, and he has a 9-7 record, 2.90 ERA and 1.08 WHIP.

Kansas City Royals @ Athletics Betting Trends: September 26, 2025

• Probable Starting Pitcher: TBD

Why the Athletics will win

• The Athletics have won each of their last six games against AL Central opponents.
• The Royals have lost nine of their last 10 games following a road win.
• The Athletics have covered the run line in each of their last six games against the Royals.
• The Royals have failed to cover the run line in each of their last four games against AL West opponents following a win.
• The Athletics have led after 3 innings in five of their last six games against AL Central opponents.
• The Athletics have led after 5 innings in four of their last five games against opponents that held a winning record.

• Probable Starting Pitcher: Noah Cameron      Record this season: 9-7      ERA: 2.90
• Road Record: 4-4
• Last 5 against Athletics: 0-0

Why the Kansas City Royals will win

• The road team has won each of the last four games between the Royals and Athletics.
• The Athletics have lost three of their last four games after playing the previous day.
• The Royals have covered the run line in 11 of their last 13 road games against AL West opponents.
• The Athletics have failed to cover the run line in four of their last five games after playing the previous day.
• The Royals have led after 5 innings in five of their last six night games.
• The Royals have won the first inning in three of their last four road games against American League opponents.
• The Royals have led after 3 innings in nine of their last 11 road games against AL West opponents.

Total Runs Facts

• Five of the Royals’ last six road games have gone OVER the total runs line.
• Five of the Athletics’ last six home games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Royals’ last 10 road games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Athletics’ last seven home games against American League opponents.

Athletics Player Prop Facts

• Nick Kurtz has recorded at least one hit in each of the Athletics’ last 11 games against AL Central opponents.
• Zack Gelof has hit a home run in each of his last three appearances against the Royals.
• Shea Langeliers has recorded a Double in five of his last six home appearances against AL Central opponents.

Kansas City Royals Player Prop Facts

• Bobby Witt Jr. has recorded at least one Double in three of the Royals’ last four road games against AL West opponents that held a losing record.
• Randal Grichuk has recorded at least one hit in each of his last nine Friday appearances against AL West teams that held a losing record.
• Vinnie Pasquantino has hit a home run in seven of the Royals’ last 11 games against AL West opponents that held a losing record.

Matchup/League Facts

• The Athletics rank 2nd in the league for doubles this season (289).
• The Athletics rank 29th in the league for home runs allowed this season (218).
• The Royals rank 2nd in the league for strikeouts against this season (1074).
• The Royals rank 29th in the league for walks this season (424).

Royals vs Athletics Prediction

The Athletics are 5-1 in their last 6 meetings against the Royals, and are 2-1 in their last 3 home meetings. Under is 7-3 in their last 10 meetings.  

In this Royals vs Athletics Prediction, the Royals are coming as -125 road favorites. Both teams have nothing to play for, but the Royals were fighting for a wild card spot until a few days ago. They are now putting their ace on the mound in Noah Cameron, who has been elite this season and better on the road. Kansas City also has a superior bullpen to back him up, so I expect them to take care of business on the road in this one.