Houston Astros vs Pittsburgh Pirates Prediction 6/3/25 MLB Picks

The Houston Astros and Pittsburgh Pirates meet Tuesday in MLB action at PNC Park. Here’s a Houston Astros vs Pittsburgh Pirates Prediction. This article will include a Houston Astros vs Pittsburgh Pirates Pick.

Houston Astros Betting Preview

The Houston Astros are 32-27 on the year and play the Guardians, White Sox, and Twins next. The Houston Astros are batting .254 on the season, have a .321 OBP, and a .391 slugging percentage. The Houston Astros pitching staff has a 3.66 ERA and a 1.17 WHIP. Jeremy Pena leads the Houston Astros with 69 hits and 30 RBI, while Jose Altuve and Isaac Paredeshave combined for 114 hits and 54 RBI. 

Lance McCullers Jr.  gets the ball for the Houston Astros, and he is 0-1 with a 5.89 ERA and 26 strikeouts this season. This will be McCullers’ first career game against the Pittsburgh Pirates.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 22-38 on the year and play the Phillies, Marlins, and Cubs next. The Pittsburgh Pirates are batting .227 on the season, have a .306 OBP, and a .340 slugging percentage. The Pittsburgh Pirates pitching staff has a 3.96 ERA and a 1.25 WHIP. Bryan Reynolds leads the Pittsburgh Pirates with 54 hits and 34 RBI while Isiah Kiner-Falefa and Ke’Bryan Hayes have combined for 97 hits and 31 RBI.

Paul Skenes gets the ball for the Pittsburgh Pirates, and he is 4-5 with a 2.15 ERA and 77 strikeouts this season. This will be Skenes’ second career game against the Houston Astros.

Why the Pittsburgh Pirates will win

• The Astros have lost each of their last six road games against National League opponents following a win.
• The Pirates have won five of their last six night games against the Astros at PNC Park following a loss.
• The Astros have failed to cover the run line each of their last six road games against NL Central opponents that held a losing record.
• The Pirates have covered the run line in each of their last six games against AL West opponents.
• The Pirates have led after 5 innings in five of their last six games against AL West opponents that held a winning record.
• The Pirates have led after 3 innings in each of their last three night games against American League opponents.

Why the Houston Astros will win

• The Pirates have lost six of their last seven games as favorites.
• The Astros have won each of their last three games as underdogs.
• The Pirates have failed to cover the run line in 17 of their last 18 games as home favorites against American League opponents following a loss.
• The road team has covered the run line in seven of the last eight games between the Astros and Pirates.
• The Astros have led after 3 innings in each of their last three night games against opponents that held a losing record.
• The Astros have led after 5 innings in four of their last five games as underdogs.

Pittsburgh Pirates Player Prop Facts

• Andrew McCutchen has hit a home run in each of the Pirates’ last two games against opponents that held a winning record.
• Isiah Kiner-Falefa has recorded a Double in each of his last three appearances with his team as a home favorite against AL West opponents.
• Andrew McCutchen has recorded at least one RBI in each of the Pirates’ last four night games against AL West opponents that held a winning record.
• Oneil Cruz has scored at least one run in six of his last seven home appearances.
• Isiah Kiner-Falefa has recorded at least one Single in each of his last nine appearances with his team as a home favorite against AL opponents.
• Ke’Bryan Hayes has recorded at least one hit in each of his last 10 appearances against AL opponents.
• Paul Skenes ranks 8th amongst qualified players for Earned Run Average (2.15) this season.

Houston Astros Player Prop Facts

• Isaac Paredes has hit at least one home run in each of the Astros’ last two road games against opponents that held a losing record.
• Isaac Paredes has recorded a Double in each of the Astros’ last three games against NL Central opponents that held a losing record.
• Victor Caratini has recorded an RBI in each of his last three road appearances against the Pirates.
• Yainer Diaz has scored at least one run in four of the Astros’ last five night games.
• Jake Meyers has recorded a Single in each of the Astros’ last six road games.
• Lance McCullers Jr. has recorded seven or more strikeouts in seven of his last nine road appearances against opponents that held a losing record.
• Isaac Paredes has recorded at least one hit in each of his last eight road appearances against opponents that held a losing record.

Houston Astros vs Pittsburgh Pirates Prediction

The Astros and the plus money are intriguing when you consider they’re the better team, but the Pirates have a clear pitching edge. McCullers hasn’t pitched much over the years, and he’s still trying to figure things out this season, allowing 20 hits and 12 earned runs in 18.1 innings. Skenes is one of the best pitchers in baseball with his 2.15 ERA and 0.92 WHIP, and he’s allowed 25 hits and eight runs in his last 37.2 innings. The Pirates are dirt as a team, but with the overwhelming edge on the mound, I’ll give them the edge on Tuesday night.