Houston Astros vs Oakland Athletics Prediction 9/24/2025 Today’s MLB Picks

In this article, we will formulate an Astros vs Athletics Prediction for this MLB game on Wednesday, September 24th at the Sutter Health Park in the second game of this series, with the Athletics having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Athletics Preview

The Athletics have a 74-83 record this season and are sitting on the last place of the AL West. The Athletics have a 34-42 home record and are 76-74 in over/under. They are coming off a 5-1 home victory over the Astros, that ended their two-game losing streak. Under is 10-4 in their last 14 games and are playing the Royals next.

The Athletics have a .253 batting average this season, .318 OBP and .432 Slugging percentage. Athletics’ pitching staff has a 4.69 ERA and 1.36 WHIP. Brent Rooker leads the Athletics with 162 hits, while Jacob Wilson is the team’s best hitter with a .318 batting average. Tyler Soderstrom adds a team-high 91 RBI, while Nick Kurtz adds a team-high 33 home runs. 

Luis Severino (R) is the projected starter for the Athletics, and he has a 7-11 record, 4.72 ERA, and 1.33 WHIP.

Houston Astros Preview

The Houston Astros have an 84-73 record this season and are sitting on the second place of the AL West. The Astros have a 38-38 road record and 72-79 in over/under. They are coming off a 1-5 road defeat by the A’s, and have four consecutive losses. They are playing the Angels next.

The Astros have a .250 batting average this season, .316 OBP and .397 slugging percentage. Houston’s pitching staff has a 3.87 ERA and 1.22 WHIP. Jose Altuve leads the Astros with 152 hits, adding a team-high 26 home runs. Jeremy Pena is the team’s best hitter with a .304 batting average, while Christian Walker leads the team in RBI with 82. 

Hunter Brown (R) is the projected starting pitcher for the Astros, and he has a 12-8 record, 2.30 ERA and 1.01 WHIP.

Houston Astros @ Athletics Betting Trends: September 24, 2025

• Probable Starting Pitcher: Luis Severino      Record this season: 7-11      ERA: 4.72
• Home Record: 1-9
• Last 5 against Astros: 1-1

Why the Athletics will win

• The Athletics have won each of their last five games as underdogs against the Astros.
• The Astros have lost five of their last six games as road favorites against American League opponents.
• The Athletics have covered the run line each of their last seven games against teams that held a winning record.
• The Astros have failed to cover the run line in 10 of their last 11 night games against AL West opponents that held a losing record.
• The Athletics have won the first inning in each of their last four games against the Astros.
• The Athletics have led after 3 innings in five of their last six games against the Astros.
• The Athletics have led after 5 innings in each of their last six games against the Astros.

• Probable Starting Pitcher: Hunter Brown      Record this season: 12-8      ERA: 2.30
• Road Record: 7-2
• Last 5 against Athletics: 3-2

Why the Houston Astros will win

• The Astros have won 14 of their last 15 games against AL West opponents following a road loss.
• The Athletics have lost seven of their last eight games against the Astros following a home win.
• The Astros have covered the run line in each of their last eight night games against American League opponents following a road loss.
• The Athletics have failed to cover the run line in five of their last six games against the Astros following a home win.
• The Astros have led after 5 innings in each of their last eight Wednesday night games against the Athletics.
• The Astros have led after 3 innings in five of their last six road night games.

Total Runs Facts

• Seven of the Athletics’ last eight games against American League opponents have gone UNDER the total runs line.
• Seven of the Astros’ last eight road games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 10 of the Athletics’ last 11 games against American League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Astros’ last nine road games against AL West opponents.

Athletics Player Prop Facts

• Nick Kurtz has recorded at least one Double in three of his last four appearances against the Astros.
• Shea Langeliers has hit a home run in each of the Athletics’ last three games as underdogs against the Astros.
• Lawrence Butler has recorded at least one hit in each of his last nine home appearances against opponents that held a winning record.
• Luis Severino has recorded a win in four of his last five appearances with the Athletics as underdogs.
• Luis Severino has recorded five or more strikeouts in each of his last four appearances against AL West opponents.
• Jacob Wilson ranks 2nd amongst qualified players for Batting Average (.318) this season.

Houston Astros Player Prop Facts

• Victor Caratini has hit a home run in three of his last four appearances with the Astros as road favorites against the Athletics.
• Yordan Alvarez has recorded a Double in each of his last three road appearances against the Athletics.
• Christian Walker has recorded at least one hit in each of the Astros’ last 17 road games against opponents that held a losing record.
• Hunter Brown ranks 3rd amongst qualified players for Earned Run Average (2.30) this season.

Matchup/League Facts

• The Athletics rank T2nd in the league for doubles this season (285).
• The Athletics rank 29th in the league for home runs allowed this season (217).
• The Astros rank 1st in the league for strikeouts this season (1461).
• The Astros rank 27th in the league for steals this season (78).

Astros vs Athletics Prediction

The Athletics have won their last 7 head-to-head meetings against the Astros, and are 3-2 in their last 5 home meetings against the Astros. Under is 4-1 in their last 5 meetings.

In this Astros vs Athletics Prediction, the Astros are coming as -150 road favorites. The Astros have fallen out of the top of the AL West with their recent struggles, and have now fallen to the Wild Card fight. They are putting their ace on the mound in Hunter Brown, who has been elite this season, and in excellent form lately, with a 2.01 ERA in his last 5 starts. Severino takes the mound for the A’s, and he has been terrible at home, with a 6.51 ERA, and the Astros have a far better bullpen. This is the perfect bounce-back spot for the struggling Astros, so take them on the moneyline on the road in this one.