Houston Astros vs Los Angeles Angels Prediction 9/28/2025 Today’s MLB Picks

In this article, we will formulate an Astros vs Angels Prediction for this MLB game on Sunday, September 28th at the Angel Stadium in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Angels Preview

The Los Angeles Angels have a 72-89 record this season and are sitting on the 4th place of the AL West. The Angels have a 39-41 home record and 87-71 in over/under They are coming off a 1-6 home defeat by the Astros, and are 3-8 in their last 11 games. Under is 5-2 in their last 7 games.

The Angels have a .225 batting average this season, .298 OBP and .398 Slugging percentage. LA’s pitching staff has a 4.88 ERA and 1.43 WHIP. Taylor Ward leads the Angels with 132 hits, while Nolan Schanuel is the team’s best hitter with a .264 batting average. Taylor Ward leads the team with 103 RBI, while Jo Adell adds a team-high 37 home runs.

Sam Aldegheri (R) is the projected starting pitcher for the Angels, and he has a 0-1 record, 8.00 ERA and 2.22 WHIP.

Houston Astros Preview

The Houston Astros have an 86-75 record this season and are sitting on the second place of the AL West. The Astros have a 40-40 road record and 73-82 in over/under. They are coming off a 6-1 road victory over the Angels, and are 2-6 in their last 8 games. Under is 4-1 in their last 5 games.

The Astros have a .250 batting average this season, .315 OBP and .397 slugging percentage. Houston’s pitching staff has a 3.88 ERA and 1.23 WHIP. Jose Altuve leads the Astros with 156 hits, while Jeremy Pena is the team’s best hitter with a .304 batting average. Christian Walker leads the team in RBI with 88, adding a team-high 27 home runs 

Lance McCullers Jr. (R) is the projected starting pitcher for the Astros, and he has a 2-5 record, 6.71 ERA and 1.85 WHIP.

Houston Astros @ Los Angeles Angels Betting Trends: September 28, 2025

• Probable Starting Pitcher: Samuel Aldegheri      Record this season: 0-1      ERA: 8.00
• Home Record: 0-1
• Last 5 against Astros: 0-1

Why the Los Angeles Angels will win

• The Astros have lost each of their last six day games against American League opponents following a win.
• The Angels have won eight of their last nine games against AL West opponents following a home loss.
• The Angels have covered the run line in eight of their last nine games against AL West opponents following a home loss.
• The Astros have failed to cover the run line in seven of their last eight games against AL West opponents following a road win.
• The Astros have trailed after 3 innings in three of their last four day games.
• The Angels have led after 5 innings in each of their last three day games at Angel Stadium of Anaheim against AL West opponents.

• Probable Starting Pitcher: Lance McCullers Jr.      Record this season: 2-5      ERA: 6.71
• Road Record: 2-1
• Last 5 against Angels: 3-1

Why the Houston Astros will win

• The Angels have lost 12 of their last 14 day games against American League opponents that held a winning record.
• The Astros have won 12 of their last 16 road games against the Angels.
• The Angels have failed to cover the run line in 10 of their last 13 games.
• The Astros have covered the run line in three of their last four day games against American League opponents that held a losing record.
• The Angels have trailed after 3 innings in three of their last four day games against American League opponents that held a winning record.
• The Angels have trailed after 5 innings in seven of their last eight games against American League opponents.

Total Runs Facts

• Eight of the Astros’ last nine road games against American League opponents have gone UNDER the total runs line.
• Five of the last six games between the Astros and Angels have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last eight games between the Astros and Angels.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last four games at Angel Stadium of Anaheim.

Los Angeles Angels Player Prop Facts

• Mike Trout has hit at least one home run in two of the Angels’ last three games.
• Taylor Ward has recorded at least one hit in each of his last seven appearances after playing the previous day.

Houston Astros Player Prop Facts

• Christian Walker has recorded at least one hit in each of the Astros’ last 21 road games against opponents that held a losing record.
• Christian Walker has hit at least one home run in each of the Astros’ last three games.

Matchup/League Facts

• The Angels rank 30th in the league for doubles this season (212).
• The Angels rank 30th in the league for strikeouts against this season (1618).
• The Astros rank 1st in the league for strikeouts this season (1495).
• The Astros rank T26th in the league for triples this season (12).

Astros vs Angels Prediction

The Angels are 3-2 in their last 5 meetings against the Astros, but the Astros are 3-2 in their last 5 meetings in LA. Under is 5-1 in their last 6 meetings.  

The Astros got eliminated from the playoffs even though they won yesterday, so there should be disappointment in their ranks today. They are putting Lance McCullers on the mound, who has been terrible this season, and coming into this matchup in atrocious form, with a 9.95 ERA in his last 5 starts. Aldegheri has been bad in his only start for the Angels, and I expect a lot of runs in the final game of the season for both teams. Take the over the total.