Pick details
| MATCHUP | Houston Astros | Cleveland Guardians |
|---|---|---|
| Team Records | 9-16 | 14-11 |
| Where | Progressive Field, Cleveland, Ohio | |
| When | Wednesday, April 22, 2026 | |
| Time | 01:10 PM EDT | |
| TV | MLB.TV | |
Houston Astros Betting Preview
The Houston Astros are 9-16 on the year and play the Yankees and Orioles next. The Houston Astros are batting. 262 on the season, have a .352 OBP, and have a .438 slugging percentage. The Houston Astros pitching staff has a 6.05 ERA and a 1.65 WHIP. Yordan Alvarez leads the Houston Astros with 30 hits and 24 RBI while Carlos Correa and Jose Altuve have combined for 49 hits and 21 RBI.
Peter Lambert gets the ball for the Houston Astros, and he is 0-1 with a 7.20 ERA and 8 strikeouts this season. This will be Lambert’s second career game against the Cleveland Guardians.
Cleveland Guardians Betting Preview
The Cleveland Guardians are 14-11 on the year and play the Blue Jays and Rays next. The Cleveland Guardians are batting. 231 on the season, have a .321 OBP, and have a .383 slugging percentage. The Cleveland Guardians pitching staff has a 4.08 ERA and a 1.28 WHIP. Brayan Rocchio leads the Cleveland Guardians with 21 hits and 15 RBI while Steven Kwan and Jose Martinez have combined for 42 hits and 20 RBI.
Tanner Bibee gets the ball for the Cleveland Guardians, and he is 0-2 with a 4.81 ERA and 23 strikeouts this season. Bibee is 0-0 with a 4.50 ERA and 13 strikeouts in his career against the Houston Astros.
Why the Cleveland Guardians will win
- The Astros have lost nine of their last 10 road games.
- The Guardians have won each of their last 11 Wednesday games as favorites against AL West opponents.
- The Guardians have covered the run line in each of their last six Wednesday games against the Astros.
- The Astros have failed to cover the run line each of their last six Wednesday games against AL Central opponents that held a winning record.
- The Astros have trailed after 3 innings in six of their last eight games against American League opponents that held a winning record.
- The Guardians have won the first inning in three of their last four home games against AL West opponents.
- The Guardians have led after 5 innings in 15 of their last 20 day games against the Astros.
Why the Houston Astros will win
- The underdogs have won four of the last five games between the Astros and Guardians.
- The Guardians have lost four of their last five games as home favorites following a win.
- The Astros have covered the run line in each of their last six games as road underdogs against AL Central opponents following a road loss.
- The Guardians have failed to cover the run line in each of their last five games as home favorites against the Astros following a win.
- The Astros have led after 5 innings in six of their last seven games against the Guardians at Progressive Field.
Total Runs Facts
- Eight of the Astros’ last nine games as underdogs have gone OVER the total runs line.
- Six of the Guardians’ last seven games against AL West opponents have gone OVER the total runs line.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last 10 games as underdogs against American League opponents.
- The ‘Inning 1 UNDER 0.5 runs’ market has been hit in each of the last six day games between the Astros and Guardians at Progressive Field.
Cleveland Guardians Player Prop Facts
- Jose Ramirez has hit at least one home run in three of the Guardians’ last seven games as favorites.
- Jose Ramirez has recorded at least one hit in each of his last 11 home appearances against the Astros after playing the previous day.
Houston Astros Player Prop Facts
- Yordan Alvarez has hit a home run in three of the Astros’ last five games against opponents that held a winning record.
- Yordan Alvarez has recorded at least one hit in each of the Astros’ last eight games.
- Yordan Alvarez ranks 2nd amongst qualified players for Slugging Percentage (.747) this season.
Matchup/League Facts
- The Guardians rank T24th in the league for home runs allowed this season (31).
- The Guardians rank T22nd in the league for triples this season (1).
- The Astros rank 30th in the league for walks allowed this season (137).
- The Astros rank 30th in the league for runs allowed this season (150).
Houston Astros vs Cleveland Guardians Prediction
I’ve been fading the Astros a lot this season because of their pitching staff and it’s worked out up to this point. That doesn’t change here. Lambert has been horrible through five innings, posting a 7.20 ERA and 1.60 WHIP. Bibee has had his hiccups as well, with a 4.81 ERA and 1.52 WHIP, but he’s averaging nearly a strikeout per inning and his numbers are still better than anything the Astros are doing these days. It’s awful, folks. I’m going to continue betting against the Astros. Give me the Guardians.
