Houston Astros vs Baltimore Orioles Prediction 8/21/2025 Today’s MLB Picks

The Houston Astros and the Baltimore Orioles meet Thursday in MLB action from Camden Yards. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Baltimore Orioles prediction.

Starting Pitching Matchup

The Houston Astros will trot out Jason Alexander for the start here and Alexander is 3-1 with a 4.74 ERA and 35 strikeouts this season. The Baltimore Orioles will start Brandon Young here and Young is 1-6 with a 5.68 ERA and 46 strikeouts this season.

Houston Astros Recap

The Houston Astros come into this game looking to rebound from their 7-2 loss at the hands of the Detroit Tigers last time out to sit at 69-58 this season. After this series, the Astros will head home for a series against the Colorado Rockies.

Astros Drop 4^th In A Row

Jose Altuve has 130 hits including 18 doubles, 22 home runs and 64 RBIs. Jeremy Pena also has 117 hits with 21 doubles, 13 homers and 45 RBIs with 17 stolen bases as well. Jake Meyers has 15 doubles as well and Christian Walker has 16 home runs and 65 RBIs but has also accrued a team-high 134 strikeouts so far this season. Altuve also has 9 stolen bases while Jake Meyers has 14 stolen bases this season. Isaac Paredes also has 19 home runs with 50 RBIs of his own and Cam Smith has contributed 7 homers and 48 RBIs.

Why the Houston Astros will win

The Astros have won each of their last nine night games against AL East opponents following a loss.
The Orioles have lost each of their last four games as favorites after going to extra innings.
The underdogs have covered the run line in each of the Orioles’ last 12 games.
The Orioles have failed to cover the run line in each of their last 10 games as favorites following a road win.

Houston Astros Player Prop Facts

Jake Meyers has recorded at least one hit in each of his last 16 road appearances against AL opponents.
Jose Altuve has hit a home run in three of his last four road appearances against the Orioles after playing the previous day.
Jeremy Pena ranks 3rd amongst qualified players for Batting Average (.310) this season.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to add on their 4-3 win over the Boston Red Sox on Tuesday to sit at 59-67 this season. After this series, the Orioles will head home for a rematch series against the Red Sox.

Orioles Win 3 Straight and 6 Of Last 7

Adley Rutschman has 70 hits with 16 doubles, 9 homers and 29 RBIs. Jackson Holliday has 116 hits with 17 doubles, 2 triples, 15 homers and 48 RBIs. Gunnar Henderson has 125 hits with 29 doubles, 5 triples, 15 home runs and 57 RBIs with 16 stolen bases and 110 strikeouts while Holliday has a team-high 115 strikeouts as well this season. Heston Kjerstad’s added 4 homers and 19 RBIs while Jordan Westburg has 15 home runs and 34 RBIs this season.

Why the Baltimore Orioles will win

The Astros have lost seven of their last eight games against American League opponents that held a losing record.
The Orioles have won each of their last four games against the Astros after going to extra innings.
The Astros have failed to cover the run line each of their last 17 games against American League opponents that held a losing record.
The Orioles have covered the run line each of their last nine games against teams that held a winning record.

Baltimore Orioles Player Prop Facts

Tyler O’Neill has hit a home run in four of his last five appearances with the Orioles as favorites.
Gunnar Henderson has recorded a Double in each of the Orioles’ last four games against AL West opponents at Oriole Park at Camden Yards.
Gary Sanchez has recorded at least one hit in each of his last 10 appearances with his team as a favorite against AL West opponents.

Total Runs Facts

Each of the Orioles’ last four home games against AL West opponents have gone UNDER the total runs line.
Four of the Astros’ last five games have gone OVER the total runs line.

Houston Astros vs. Baltimore Orioles Prediction

I’m going to lean towards the Orioles in this one. Earlier this month, the Orioles were horrendous against lefties and couldn’t hit their way out of a wet paper bag in those outings. That’s changed right now though, as the Orioles’ offense has woken up and I think that they can keep their hot ways going here. The Astros have hit a wall over the last week and just aren’t a team I’m looking to back right now even against Brandon Young, who might be my least favorite option in this Orioles rotation. I think Houston is in some trouble here, I’ll roll with Baltimore in this one.