Houston Astros vs Athletics Prediction 9/23/2025 Today’s MLB Picks

The Houston Astros and Athletics meet Tuesday in MLB action at Sutter Health Park. Here’s a Houston Astros vs Athletics Prediction. This article will include a Houston Astros vs Athletics Pick.

Houston Astros Betting Preview

The Houston Astros are 84-72 on the year and play the Angels next. The Houston Astros are batting .251 on the season, have a .316 OBP, and a .398 slugging percentage. The Houston Astros pitching staff has a 3.87 ERA and a 1.22 WHIP. Jose Altuve leads the Houston Astros with 152 hits and 75 RBI, while Jeremy Pena and Yainer Diaz have combined for 283 hits and 130 RBI.

Cristian Javier gets the ball for the Houston Astros, and he is 2-3 with a 4.45 ERA and 30 strikeouts this season. Javier is 4-4 with a 3.92 ERA and 68 strikeouts in his career against the Athletics.

Athletics Betting Preview

The Athletics are 73-83 on the year and play the Royals next. The Athletics are batting .253 on the season, have a .318 OBP, and a .432 slugging percentage. The Athletics pitching staff has a 4.72 ERA and a 1.36 WHIP. Brent Rooker leads the Athletics with 162 hits and 87 RBI while Tyler Soderstrom and Jacob Wilson have combined for 298 hits and 149 RBI.

Jeffrey Springs gets the ball for the Athletics, and he is 10-11 with a 4.17 ERA and 135 strikeouts this season. Springs is 2-0 with a 4.70 ERA and 7 strikeouts in his career against the Houston Astros.

Houston Astros @ Athletics Betting Trends: September 23, 2025

• Probable Starting Pitcher: Jeffrey Springs      Record this season: 10-11      ERA: 4.17
• Home Record: 5-5
• Last 5 against Astros: 2-0

Why the Athletics will win

• The underdogs have won each of the last five games between the Astros and Athletics.
• The Astros have lost each of their last six night games against AL West opponents following a home loss.
• The Astros have failed to cover the run line in eight of their last nine games as road favorites against American League opponents.
• The underdogs have covered the run line in seven of the Athletics’ last eight games.
• The Astros have trailed after 3 innings in each of their last three games.
• The Astros have trailed after 5 innings in each of their last three games.

• Probable Starting Pitcher: Cristian Javier      Record this season: 2-3      ERA: 4.45
• Road Record: 0-1
• Last 5 against Athletics: 3-2

Why the Houston Astros will win

• The Athletics have lost each of their last four games against AL West opponents that held a winning record.
• The Astros have won each of their last six games as road favorites against AL West opponents following a loss.
• The Astros have covered the run line in 11 of their last 12 road games against AL West opponents following a home loss.
• The Athletics have failed to cover the run line each of their last four games against AL West opponents that held a winning record.
• The Athletics have trailed after 3 innings in each of their last four night games.
• The Astros have led after 5 innings in seven of their last nine road night games.

Total Runs Facts

• Six of the Athletics’ last seven games against American League opponents have gone UNDER the total runs line.
• Six of the Astros’ last seven road games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 10 of the Astros’ last 11 road games against AL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Athletics’ last eight games as underdogs against American League opponents.

Athletics Player Prop Facts

• Shea Langeliers has hit a home run in each of the Athletics’ last three games as underdogs against the Astros.
• Lawrence Butler has recorded at least one hit in each of his last eight appearances at Sutter Health Park against opponents that held a winning record.
• Brent Rooker has recorded a Double in three of the Athletics’ last four games against AL West opponents at Sutter Health Park.
• Jacob Wilson is one of only seven players to hit over .300 and have 45+ RBIs this season.

Houston Astros Player Prop Facts

• Cristian Javier has recorded five or more strikeouts in seven of his last eight road appearances against AL West opponents that held a losing record.
• Jake Meyers has recorded at least one hit in each of his last 14 appearances with the Astros as road favorites against AL opponents.
• Cristian Javier has recorded a win in three of his last four appearances with the Astros as favorites against the Athletics.
• Victor Caratini has hit a home run in three of his last four appearances with the Astros as road favorites against the Athletics.
• Yordan Alvarez has recorded a Double in each of his last three appearances with the Astros as road favorites against the Athletics.
• Jeremy Pena is one of only seven players to hit over .300 and have 45+ RBIs this season.

Matchup/League Facts

• The Athletics rank 4th in the league for slugging percentage this season (.432).
• The Athletics are one of only four teams in the league to rank top 10 in both home runs and batting average this season.
• The Astros rank 26th in the league for triples this season (12).
• The Astros rank 26th in the league for walks this season (454).

Houston Astros vs Athletics Prediction

The Astros need to take advantage of games like this if they’re going to make the playoffs, but I’m looking at the over. Javier has allowed 17 hits and 10 runs in his last 16.1 innings, and he has a 7.88 ERA and .281 allowed batting average in 8 road innings. Springs has been hittable this season, especially at home through 77.1 innings where he has a 5.00 ERA and .254 allowed batting average. I expect some offense on Tuesday night. Give me the over.