Guardians vs Twins Prediction 5/20/25 MLB Picks

In this article, we will formulate a Guardians vs Twins prediction for this MLB game on Tuesday, May 20th at Target Field in Minneapolis, Minnesota. Let’s take a look at the prediction for this MLB matchup. 

These two teams tried playing game one on Monday night, but play was suspended in the fourth inning with Minnesota up 2-1. They will finish game one on Tuesday evening before starting game two, and none of those stats from game one are included in this article. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 25-21 this year after they lost all three games against Cincinnati by scores of 4-5, 1-4, and 1-3. In their game three loss, Cleveland had plenty of baserunners, but only managed one run in the seventh inning for the loss. The Guardians recorded nine hits and they committed one error in the game, while they were led by Santana, who had the lone RBI in the game. Cleveland started Ortiz, who allowed six hits and two earned runs over 5.0 innings for the loss, while Gaddis allowed two hits and one earned run in the sixth. 

Prior to that series, the Guardians won two out of three against the Brewers, but dropped two out of three against the Phillies before that. Cleveland has lost four games in a row, and they are currently third in the AL Central standings. The Cleveland pitching staff has a 4.14 ERA with a 1.41 WHIP and a .260 opponent batting average, while the offense has scored 182 runs with a .233 batting average and a .307 on-base percentage this season. Kyle Manzardo has led Cleveland with 10 home runs and 25 RBIs, while Jose Ramirez has added nine home runs and 23 RBIs this year. The projected starting pitcher for Cleveland is Gavin Williams, who is 3-2 with a 4.29 ERA and a 1.64 WHIP over 42.0 innings pitched this year. 

Minnesota Twins Betting Preview

The Minnesota Twins are 26-21 this season after they won two out of three against Milwaukee by scores of 3-0, 7-0, and 2-5. In their game three loss, Minnesota cut the deficit to 4-2 in the seventh inning, but couldn’t get any closer in the loss. The Twins recorded six hits in the game, and they were led by Lee and Lewis, who both had one RBI in the loss. Minnesota started Matthews, who allowed five hits and four earned runs over 3.0 innings for the loss, while Alcala allowed one earned run in the eighth. 

Prior to that series, the Twins swept the Orioles in three games and swept the Giants in three games. Minnesota has won 13 of its last 14 games, and they are currently second in the AL Central standings. The Minnesota pitching staff has a 3.20 ERA with a 1.14 WHIP and a .228 opponent batting average, while their offense has scored 194 runs with a .242 batting average and a .310 on-base percentage this season. Byron Buxton (IL) has led Minnesota with 10 home runs and 27 RBIs, while Trevor Larnach has added seven home runs and 23 RBIs this year. The projected starting pitcher for Minnesota is Chris Paddack, who is 2-3 with a 4.05 ERA and a 1.18 WHIP over 46.2 innings pitched this season. 

Why the Twins will beat the Guardians 

• The Twins have won each of their last nine home games.
• The Guardians have lost each of their last four games.
• The Twins have covered the run line in each of their last six home games against American League opponents.
• The Guardians have failed to cover the run line in seven of their last eight road games against American League opponents that held a winning record.
• The Guardians have trailed after 3 innings in four of their last five road games against American League opponents that held a winning record.
• The Guardians have trailed after 5 innings in four of their last five road games against American League opponents.

Total Runs Facts

• Each of the Guardians’ last four night games after playing the previous day have gone UNDER the total runs line.
• Six of the Twins’ last seven games as favorites against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 10 of the Guardians’ last 11 games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Twins’ last four games as favorites.

Minnesota Twins Player Prop Facts

• Ty France has recorded at least one RBI in five of his last six appearances at Target Field against AL opponents that held a winning record.
• Trevor Larnach has scored at least one run in seven of the Twins’ last eight games.
• Ty France has recorded at least one Single in seven of the Twins’ last eight games against AL Central opponents.
• Willi Castro has recorded at least one hit in each of his last 11 appearances with the Twins as home favorites against AL Central opponents.
• Bailey Ober has recorded five or more strikeouts in eight of his last nine home appearances against AL opponents.
• Bailey Ober has recorded a win in each of his last four appearances with the Twins as home favorites against AL Central opponents.
• Byron Buxton has hit a home run in four of the Twins’ last seven games against AL opponents.

Cleveland Guardians Player Prop Facts

• Carlos Santana has recorded an RBI in four of the Guardians’ last five games as underdogs.
• Steven Kwan has scored at least one run in each of the Guardians’ last five night games against AL opponents that held a winning record.
• Jose Ramirez has recorded at least one Single in 14 of his last 15 appearances with the Guardians as underdogs.
• Steven Kwan has recorded at least one hit in each of the Guardians’ last 11 games against AL opponents that held a winning record.
• Austin Hedges has hit a home run in each of his last two appearances with the Guardians as road underdogs against the Twins.
• Jose Ramirez ranks T7th in the league in Steals (12) this season.

Matchup/League Facts

• The Twins rank 3rd in the league for ERA this season (3.20).
• The Twins rank 26th in the league for walks this season (132).
• The Guardians rank T24th in the league for triples this season (3).
• The Guardians rank 24th in the league for opponent batting average this season (.260).

Twins vs Guardians Prediction 

Cleveland comes into this series after losing four games in a row, and they have scored one run in each of their last two games. The Guardians are 11-13 on the road this year, while the Twins are 15-6 at home. Minnesota is red hot right now, but they are coming off a loss on Sunday against Milwaukee. The Twins are starting Paddack, who has allowed two earned runs or fewer in four of his last five starts. The Guardians are starting Williams, who has also allowed two earned runs or fewer in four of his last five. This should be a pretty good pitching matchup, but I will side with the hotter team at home. Take Minnesota here.