Guardians vs Red Sox Prediction 9/3/2025 Today’s MLB Picks

In this article we will formulate a Guardians vs Red Sox prediction for this MLB game on Wednesday, September 3rd at Fenway Park in Boston, Massachusetts. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 68-69 this year after they lost the first two games in this series by scores of 6-4 and 11-7. In their game two loss, Cleveland led 1-0 in the first and 7-5 in the sixth, but they allowed the last six runs for the loss. The Guardians recorded 11 hits in the game and they were led by Rocchio, who went 2-4 with one home run and three RBIs in the loss. Cleveland started Cecconi, who allowed 11 hits and seven earned runs over 5.1 innings, while Gaddis picked up the loss in relief. 

Prior to this series, the Guardians won two out of three against the Mariners and two out of three against the Rays. Cleveland has lost three games in a row and they are currently third in the AL Central standings. The Cleveland pitching staff has a 3.99 ERA with a 1.32 WHIP and a .246 opponent batting average, while the offense has scored 530 runs with a .223 batting average and a .294 on base percentage this season. Jose Ramirez has led Cleveland with 26 home runs and 68 RBIs, while Kyle Manzardo has added 24 home runs and 61 RBIs this year. The projected starting pitcher for Cleveland is Logan Allen, who is 7-10 with a 4.42 ERA and a 1.44 WHIP over 134.1 innings pitched this year. 

Boston Red Sox Betting Preview

The Boston Red Sox are 78-62 this season after they won game two by a score of 11-7 on Tuesday night. Boston blew a 5-1 lead in the third inning, but they bounced back and outscored Cleveland 6-0 to end the game with the win. The Red Sox recorded 18 hits in the game and they were led by Rafaela, who went 2-4 with one home run and four RBIs in the game. Boston started Crochet, who allowed nine hits and seven earned runs over 6.0 innings, while Slaten picked up the win in relief. 

Prior to this series, the Red Sox lost two out of three against the Pirates, but did win all four against the Orioles before that. Boston has won seven of their last nine games and they are tied for second in the AL East standings. The Boston pitching staff has a 3.71 ERA with a 1.29 WHIP and a .243 opponent batting average, while their offense has scored 695 runs with a .255 batting average and a .325 on base percentage this season. Wilyer Abreu (IL) has led Boston with 22 home runs and 69 RBIs, while Trevor Story has added 23 home runs and 88 RBIs this year. The projected starting pitcher for Boston is Brennan Bernardino, who is 4-2 with a 3.08 ERA and a 1.25 WHIP over 49.2 innings pitched this season. 

Why the Red Sox will beat the Guardians 

The Guardians have lost each of their last six road games against American League opponents.
The Red Sox have won nine of their last 10 games against American League opponents.
The Guardians have failed to cover the run line in seven of their last eight road games against American League opponents after playing the previous day.
The Red Sox have covered the run line in seven of their last eight home games against American League opponents following a home win.
The Red Sox have led after 5 innings in four of their last five games.
The Guardians have trailed after 3 innings in three of their last four night games against opponents that held a winning record.

Why the Guardians will beat the Red Sox

The Guardians have won each of their last six Wednesday games against American League opponents.
The Red Sox have lost five of their last six games at Fenway Park against teams that held a losing record.
The Guardians have covered the run line in 11 of their last 12 night games against teams that held a winning record.
The Red Sox have failed to cover the run line in six of their last seven games against American League opponents that held a losing record.

Total Runs Facts

Each of the last six games between the Guardians and Red Sox have gone OVER the total runs line.
Three of the Guardians’ last four road games have gone OVER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Red Sox’s last seven night games at Fenway Park.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Guardians’ last 11 night games.

Boston Red Sox Player Prop Facts

Connor Wong has hit a home run in three of his last five appearances against the Guardians at Fenway Park.
Wilyer Abreu has recorded a Double in three of his last four appearances in night games against AL teams that held a losing record.
Trevor Story has recorded at least one hit in each of the Red Sox’s last 13 home games against AL opponents.

Cleveland Guardians Player Prop Facts

Austin Hedges has hit a home run in three of his four previous appearances at Fenway Park against AL opponents that held a winning record.
Jose Ramirez has recorded at least one hit in 18 of his last 19 Wednesday appearances.

Guardians vs Red Sox Prediction 

Boston was able to complete a big comeback to get the win on Tuesday night, as they remain tied with the Yankees for second in the East. The Sox are 44-27 at home this season, while the Guardians are 33-36 on the road. Cleveland has allowed 21 runs in their last three games and they are starting Allen, who has allowed 13 earned runs and 14 hits in his last 11.0 innings. Boston is going with Bernardino as an opener, with Kyle Harrison most likely coming in for bulk relief. I don’t like the pitching plans for either side, so give me the over here.