Giants vs Orioles Prediction 4/10/2026 Today’s MLB Picks

In this article we will formulate a Giants vs Orioles prediction for this MLB game on Friday, April 10th at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup. 

San Francisco Giants Betting Preview

The San Francisco Giants are 5-8 this season after they won two out of three against the Phillies by scores of 4-6, 6-0, and 5-0. In their game three win, San Francisco scored three runs in the sixth inning to take control for the shutout win. The Giants recorded nine hits in the game and they were led by Devers, who went 2-4 with one home run and four RBIs. Mahle allowed three hits and zero earned runs over 5.2 innings in the no decision, while Gage got the win in relief. Prior to that series, San Francisco lost three out of four against the Mets, but did win two out of three against the Padres before that. 

This season, San Francisco has a 4.03 ERA with a 1.34 WHIP and a .242 opponent batting average, while they have scored 41 runs with a .233 batting average and a .283 on base percentage. Matt Chapman has led the Giants with one home run and seven RBIs, while Rafael Devers has added two home runs and six RBIs. The projected starting pitcher for San Francisco is Landen Roupp, who is 1-1 with a 4.22 ERA and a 1.13 WHIP over 10.2 innings pitched this season. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 6-6 this year after they won all three against the White Sox by scores of 2-1, 4-2, and 5-3. In their game three win, Baltimore trailed 2-0 in the second inning and 3-2 in the fifth, but they scored the last three runs to escape with the victory. The Orioles recorded seven hits and they committed two errors in the game, while they were led by Ward, who went 4-5 with two RBIs. Bradish allowed six hits and two earned runs over 5.0 innings for the win, while Garcia picked up the save. Prior to that series, Baltimore lost all three against the Pirates and two out of three against the Rangers. 

This season, Baltimore has a 4.02 ERA with a 1.39 WHIP and a .239 opponent batting average, while they have scored 45 runs with a .242 batting average and a .330 on base percentage. Gunnar Henderson has led the Orioles with four home runs and nine RBIs, while Tyler O’Neill has added one home run and four RBIs. The projected starting pitcher for Baltimore is Shane Baz, who is 0-0 with a 3.27 ERA and a 1.18 WHIP over 11.0 innings pitched this year. 

Why the Baltimore Orioles will win

• The Orioles have won each of their last five home games against National League opponents that held a losing record.
• The Giants have lost each of their last seven games as underdogs against AL East opponents.
• The Orioles have covered the run line in seven of their last eight games following a road win.
• The Giants have failed to cover the run line in each of their last four games as underdogs against AL East opponents.
• The Orioles have led after 5 innings in three of their last four games as home favorites against NL West opponents.
• The Giants have trailed after 3 innings in six of their last eight games as underdogs against AL East opponents.

Why the San Francisco Giants will win

• The Orioles have lost each of their last five games as favorites against National League opponents following a road win.
• The Giants have won each of their last four games as road underdogs against American League opponents following a home win.
• The Orioles have failed to cover the run line in each of their last six home games following a win.
• The Giants have covered the run line in four of their last five games at Oriole Park at Camden Yards.
• The Orioles have trailed after 3 innings in four of their last five home night games.
• The Giants have led after 5 innings in four of their last five games at Oriole Park at Camden Yards.

Total Runs Facts

• Each of the Orioles’ last seven home games against National League opponents have gone UNDER the total runs line.
• Each of the Giants’ last four games as underdogs against the Orioles have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Orioles’ last 10 games as favorites.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the Giants’ last five games.

Baltimore Orioles Player Prop Facts

• Pete Alonso has recorded at least one hit in each of his last eight appearances in night games against NL teams that held a losing record.
• Tyler O’Neill has hit a home run in each of his last four appearances with his team as a home favorite against NL West opponents.

San Francisco Giants Player Prop Facts

• Willy Adames has hit a home run in each of his last two appearances against the Orioles after not playing the previous day.
• Rafael Devers has recorded at least one hit in each of his last seven appearances with his team as a road underdog against AL opponents.

Giants vs Orioles Prediction 

Baltimore comes into this matchup after sweeping the White Sox in their last series, but they were fortunate to not lose a game, as they could have easily lost two of them. The Orioles are 3-3 at home this year, while the Giants are 2-1 on the road. San Francisco is coming off of back to back shutouts against the Phillies, but they allowed 20 runs in the three games prior to that. The starting pitching matchup is pretty even in my opinion and with neither offense hitting the ball very well, I like the under here.

David Racey's Pick: Under 8.5