Detroit Tigers vs Cleveland Guardians Prediction 9/24/2025 Today’s MLB Picks

The Detroit Tigers and Cleveland Guardians meet Wednesday in MLB action at Progressive Field. Here’s a Detroit Tigers vs Cleveland Guardians Prediction. This article will include a Detroit Tigers vs Cleveland Guardians Pick.

Detroit Tigers Betting Preview

The Detroit Tigers are 85-72 on the year and play the Red Sox next. The Detroit Tigers are batting .247 on the season, have a .316 OBP, and a .416 slugging percentage. The Detroit Tigers pitching staff has a 3.98 ERA and a 1.25 WHIP. Riley Greene leads the Detroit Tigers with 153 hits and 110 RBI, while Gleyber Torres and Spencer Torkelson have combined for 265 hits and 152 RBI.

Jack Flaherty gets the ball for the Detroit Tigers, and he is 8-14 with a 4.60 ERA and 182 strikeouts this season. Flaherty is 2-4 with a 2.21 ERA and 48 strikeouts in his career against the Cleveland Guardians.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 85-72 on the year and play the Rangers next. The Cleveland Guardians are batting .226 on the season, have a .297 OBP, and a .373 slugging percentage. The Cleveland Guardians pitching staff has a 3.69 ERA and a 1.27 WHIP. Steven Kwan leads the Cleveland Guardians with 168 hits and 55 RBI while Jose Ramirez and Kyle Manzardo have combined for 269 hits and 150 RBI.

Tanner Bibee gets the ball for the Cleveland Guardians, and he is 11-11 with a 4.34 ERA and 157 strikeouts this season. Bibee is 3-3 with a 3.92 ERA and 43 strikeouts in his career against the Detroit Tigers.

Detroit Tigers @ Cleveland Guardians Betting Trends: September 24, 2025

• Probable Starting Pitcher: Tanner Bibee       Record this season: 11-11      ERA: 4.34
• Home Record: 4-5
• Last 5 against Tigers: 3-0

Why the Cleveland Guardians will win

• The Guardians have won each of their last eight night games against American League opponents.
• The Tigers have lost 10 of their last 11 games.
• The Guardians have covered the run line in each of their last 10 night games following a win.
• The Tigers have failed to cover the run line in 10 of their last 11 games.
• The Tigers have trailed after 3 innings in three of their last four games as road underdogs.
• The Tigers have trailed after 5 innings in three of their last four games.

• Probable Starting Pitcher: Jack Flaherty      Record this season: 8-14      ERA: 4.60
• Road Record: 3-6
• Last 5 against Guardians: 2-2

Why the Detroit Tigers will win

• The underdogs have won each of the Tigers’ last seven games.
• The Guardians have lost six of their last eight games as home favorites against the Tigers following a home win.
• The Guardians have failed to cover the run line in each of their last nine games against the Tigers at Progressive Field following a home win.
• The Tigers have covered the run line in each of their last eight games as underdogs against the Guardians following a road loss.

Total Runs Facts

• Eleven of the Guardians’ last 12 games after playing the previous day have gone UNDER the total runs line.
• Each of the Tigers’ last four night games as underdogs have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the last eight games between the Tigers and Guardians.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Tigers’ last four games against American League opponents.

Cleveland Guardians Player Prop Facts

• Steven Kwan has recorded a Double in three of the Guardians’ last four home games against the Tigers.
• Jose Ramirez has recorded at least one hit in each of the Guardians’ last six games.
• Lane Thomas has hit a home run in two of his last three appearances in night games against AL teams that held a winning record.
• Steven Kwan ranks T10th in the league in Hits (168) this season.

Detroit Tigers Player Prop Facts

• Riley Greene has hit a home run in each of the Tigers’ last two games at Progressive Field.
• Jack Flaherty has recorded six or more strikeouts in each of his last four appearances with the Tigers as road underdogs.
• Javier Baez has recorded a hit in each of his last nine appearances with the Tigers as road underdogs against AL opponents.

Matchup/League Facts

• The Guardians rank 29th in the league for on-base percentage this season (.297).
• The Guardians rank 28th in the league for slugging percentage this season (.373).
• The Tigers rank 26th in the league for strikeouts against this season (1403).
• The Tigers rank T10th in the league for runs scored this season (745).

Detroit Tigers vs Cleveland Guardians Prediction

The Tigers have one win since September 11, and I doubt Flaherty is going to turn things around with his 4.60 ERA and 1.28 WHIP. In 64 road innings, Flaherty has a 5.20 ERA and .260 allowed batting average. The Guardians are one of the hotter teams in baseball with just 2 losses since September 5, and they now have a chance to win the AL Central. Bibee has allowed 11 hits and 3 runs in his last 21.2 innings. In 80.2 home innings, Bibee has a 3.35 ERA and .225 allowed batting average. Two teams heading in different directions. I have to side with the Guardians at home as they enter the driver’s seat for the division crown.