Detroit Tigers vs Boston Red Sox Prediction 9/28/2025 Today’s MLB Picks

The Detroit Tigers and Boston Red Sox meet on Sunday in MLB action from Fenway Park. Here’s a Detroit Tigers vs Boston Red Sox prediction. We will look at this from a betting perspective and determine the best Red Sox vs Tigers pick. We will examine:

The Detroit Tigers’ recent form and player performance

The Boston Red Sox’ recent form and player performance

Recent betting trends and streaks involving the Tigers

Recent betting trends and streaks involving the Red Sox

Recent betting trends in games played between the Tigers and Red Sox

A summary that ties it all together and produces a favorable betting outcome for the Detroit and Boston game.

Tigers Clinch A Playoff Spot

The Tigers at least know they are in the playoffs, no matter what happens here, but they are still trying to pick up the American League Central victory, so still plenty to play here. On Saturday, it wasn’t the most dominant game, but the Tigers’ pitching stepped up giving up only a run on the way to the victory. The top offensive player was Jahmi Jones and he drove in two runs on two hits. 

The Tigers are averaging 4.71 runs while their pitching is giving up 4.29 runs per game. The offense is ranked 11th in all of baseball while the pitching is ranked 17th. Riley Greene has hit 36 home runs and driven in 111 RBIs so far this season. Tarik Skubal is getting the start for the Tigers and he sits with a 13-6 record and an ERA of 2.21. In his last start against the Cleveland Guardians, he went six innings giving up only three hits and one earned run. 

Why the Detroit Tigers will win

• The Tigers have won each of their last seven Sunday day games against AL East opponents.
• The Red Sox have lost each of their last four day games after playing the previous day.
• The Tigers have covered the run line in 12 of their last 13 day games against AL East opponents that held a winning record.
• The Red Sox have failed to cover the run line in eight of their last nine games at Fenway Park.
• The Tigers have led after 5 innings in six of their last seven road games.

Red Sox Clinched

The Red Sox also clinched a playoff spot, and they need to get the offense out to a faster start if they want to come away with a victory in this game. Nick Sogard drove in the only run for the Red Sox in the 2nd inning, but the rest of the game the offense couldn’t get anything going. Connely Early got the start for the Red Sox and he went five innings giving up four hits and two hits. He had seven strikeouts and one walk. 

The Red Sox are averaging 4.88 runs while their pitching is giving up 4.19 runs per game. The offense is ranked 6th best in the league while the pitching is ranked 11th. Trevor Story has hit 25 home runs and driven in 95 RBIs. 

Why the Boston Red Sox will win

• The Tigers have lost each of their last seven games at Fenway Park following a win.
• The Red Sox have won each of their last five games following a loss.
• The Red Sox have covered the run line in each of their last four home games against the Tigers following a home loss.
• The Tigers have failed to cover the run line in six of their last seven games at Fenway Park following a win.
• The Tigers have trailed after 3 innings in nine of their last 12 games at Fenway Park against opponents that held a winning record.
• The Tigers have trailed after 5 innings in three of their last four day games at Fenway Park against AL East opponents.

Detroit Tigers vs Boston Red Sox Prediction

I trust the Tigers pitching in this game, and that is going to end up being the difference here. The Red Sox are averaging 4.48 runs per game but they are going to have some major issues getting any sort of offense going in this game. Skubal sits with an ERA of 2.11 and he’s going to dominate this one. The Tigers offense has been a bit inconsistent as of late, but they aren’t going to need him a whole lot of run support to get the job done here. Back the Tigers on the money line.