Cubs vs Reds Prediction 5/25/25 MLB Picks

In this article we will formulate a Cubs vs Reds prediction for this MLB game on Sunday, May 25th at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Chicago Cubs Betting Preview

The Chicago Cubs are 31-21 this season after they split the first two games in this series by scores of 13-6 and 4-6. In their game two loss, Chicago trailed 6-1 in the fifth inning, but they did score three late runs to make the game interesting. The Cubs recorded 11 hits and they committed one error in the game, while they were led by Turner, Kelly, Crow-Armstrong, and Happ, who all had one RBI in the loss. Chicago started Rea, who allowed seven hits and six earned runs over 5.0 innings for the loss, while Brasier and Kriske finished the final three innings. 

Prior to this series, the Cubs won two out of three against the Marlins and swept the White Sox in three games. Chicago has won six of their last eight games, and they are currently first in the NL Central standings. The Chicago pitching staff has a 3.99 ERA with a 1.30 WHIP and a .250 opponent batting average, while their offense has scored 310 runs with a .263 batting average and a .336 on-base percentage this season. Pete Crow-Armstrong has led Chicago with 14 home runs and 46 RBIs, while Seiya Suzuki has added 13 home runs and 46 RBIs this year. The projected starting pitcher for Chicago is Ben Brown, who is 3-3 with a 5.44 ERA and a 1.55 WHIP over 46.1 innings pitched this season. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 26-27 this year after they won game two by a score of 6-4 on Saturday afternoon. Cincinnati had its lead cut to 2-1 in the third inning, but they scored the next four runs in the game to pull away with the win. The Reds recorded nine hits in the game, and they were led by De La Cruz, who went 2-3 with one home run and four RBIs in the win. Cincinnati started Abbott, who allowed six hits and one earned run over 5.2 innings for the win, while Pagan got the save. 

Prior to this series, the Reds lost two out of three against the Pirates, but did sweep the Guardians in three games before that. Cincinnati has lost three of its last four games, and they are currently third in the NL Central standings. The Cincinnati pitching staff has a 3.68 ERA with a 1.19 WHIP and a .227 opponent batting average, while their offense has scored 240 runs with a .244 batting average and a .320 on-base percentage this season. Elly De La Cruz has led Cincinnati with nine home runs and 37 RBIs, while Austin Hays has added six home runs and 21 RBIs this year. The projected starting pitcher for Cincinnati is Nick Lodolo, who is 4-4 with a 3.22 ERA and a 1.06 WHIP over 58.2 innings pitched this year. 

Why the Cubs will beat the Reds

• The Cubs have won each of their last 12 games against National League opponents following a road loss.
• The Reds have lost four of their last five day games against the Cubs at Great American Ball Park following a win.
• The Cubs have covered the run line in each of their last six games against National League opponents following a road loss.
• The Reds have failed to cover the run line in 11 of their last 12 day games against the Cubs at Great American Ball Park following a home win.

Total Runs Facts

• Each of the Reds’ last five games as underdogs against NL Central opponents have gone OVER the total runs line.
• Five of the Cubs’ last six games as favorites have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cubs’ last eight games as favorites.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Reds’ last four games as underdogs against National League opponents.

Cincinnati Reds Player Prop Facts

• Santiago Espinal has scored at least one run in each of the Reds’ last five games against the Cubs at Great American Ball Park.
• Nick Lodolo has recorded six or more strikeouts in each of his four previous appearances with the Reds as home underdogs against NL opponents.
• Will Benson has hit at least one home run in four of the Reds’ last six home games.
• Elly De La Cruz has recorded at least one RBI in each of the Reds’ last four day games against NL teams that held a winning record.
• Spencer Steer has recorded at least one hit in each of the Reds’ last 13 games at Great American Ball Park.
• Spencer Steer has recorded at least one Single in each of the Reds’ last seven games against NL Central opponents.
• Gavin Lux has recorded at least one Double in each of his last three appearances after playing the previous day.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has recorded at least one Double in each of the Cubs’ last three games at Great American Ball Park against NL Central opponents that held a losing record.
• Carson Kelly has scored at least one run in seven of his last eight appearances with the Cubs as road favorites against NL opponents.
• Dansby Swanson has hit a home run in six of the Cubs’ last 10 road games against NL Central opponents that held a losing record.
• Justin Turner has recorded at least one RBI in four of his last five appearances against NL opponents that held a losing record.
• Ian Happ has recorded at least one hit in each of the Cubs’ last 12 games as favorites against NL Central opponents.
• Carson Kelly has recorded at least one Single in each of his nine previous appearances with the Cubs as road favorites.

Cubs vs Reds Prediction 

Cincinnati was able to snap their three-game losing streak with a nice win on Saturday afternoon in game two, but they continue to be a very streaky team. The Reds are 14-13 at home this year, while the Cubs are 16-11 on the road. Chicago has won three of their last four games, and they have scored at least 13 runs in two of their last four. The Cubs are starting Brown, who has allowed three earned runs or more in three of his last five starts. The Reds are starting Lodolo, who has allowed two earned runs or fewer in three of his last five. I do like Lodolo on the mound, but I am going to side with this Chicago offense here.