Cubs vs Reds Prediction 9/18/2025 Today’s MLB Picks

In this article we will formulate a Cubs vs Reds prediction for this MLB game on Thursday, September 18th at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Chicago Cubs Betting Preview

The Chicago Cubs are 88-64 this year after they won all three against Pittsburgh by scores of 4-0, 4-1, and 8-4. In their game three win, Chicago scored four runs in the first inning, but needed three runs in the sixth to reclaim the lead for the victory. The Cubs recorded 10 hits and they committed one error in the game, while they were led by Happ, who went 2-4 with one home run and three RBIs in the win. Chicago started Boyd, who allowed seven hits and four earned runs over 3.0 innings, while Civale got the win in relief. 

Prior to that series, the Cubs won two out of three against the Rays and two out of three against the Braves. Chicago has won seven of their last eight games and they are second in the NL Central standings. The Chicago pitching staff has a 3.82 ERA with a 1.19 WHIP and a .241 opponent batting average, while their offense has scored 743 runs with a .250 batting average and a .322 on base percentage this season. Seiya Suzuki has led Chicago with 27 home runs and 91 RBIs, while Pete Crow-Armstrong has added 29 home runs and 90 RBIs this year. The projected starting pitcher for Chicago is Colin Rea, who is 10-6 with a 4.23 ERA and a 1.31 WHIP over 146.2 innings pitched this year. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 76-76 this season after they won two out of three against St. Louis by scores of 11-6, 0-3, and 6-2. In their game three win, Cincinnati trailed 1-0 in the first inning, but scored six of the last seven runs in the game for the win. The Reds recorded 11 hits and they committed one error in the game, while they were led by Steer, who went 3-4 with one home run and five RBIs in the win. Cincinnati started Singer, who allowed three hits and one earned run over 5.2 innings for the win, while Ashcraft got a hold. 

Prior to that series, the Reds lost all three against the Athletics, but did win two out of three against the Padres before that. Cincinnati has lost four of their last six games and they are currently third in the NL Central standings. The Cincinnati pitching staff has a 3.97 ERA with a 1.24 WHIP and a .236 opponent batting average, while their offense has scored 682 runs with a .246 batting average and a .316 on base percentage this season. Elly De La Cruz has led Cincinnati with 19 home runs and 82 RBIs, while Spencer Steer has added 18 home runs and 69 RBIs this year. The projected starting pitcher for Cincinnati is Hunter Greene, who is 6-4 with a 3.01 ERA and a 0.99 WHIP over 92.2 innings pitched this season. 

Why the Reds will beat the Cubs 

The Cubs have lost four of their last five games at Great American Ball Park following a win.
The Reds have won five of their last six night games at Great American Ball Park following a road win.
The Reds have covered the run line each of their last five night games against National League opponents that held a winning record.
The Cubs have failed to cover the run line in four of their last five road games against the Reds following a win.
The Reds have led after 3 innings in three of their last four night games against the Cubs at Great American Ball Park.
The Reds have led after 5 innings in each of their last three games against the Cubs at Great American Ball Park.

Total Runs Facts

Each of the Cubs’ last eight night games after playing the previous day have gone UNDER the total runs line.
Six of the Reds’ last seven games against National League opponents have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Reds’ last six games against NL Central opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cubs’ last three games at Great American Ball Park.

Cincinnati Reds Player Prop Facts

Hunter Greene has recorded a win in three of his four previous appearances against the Cubs at Great American Ball Park.
Spencer Steer has hit a home run in four of his last eight appearances against NL Central opponents.
Spencer Steer has recorded at least one hit in each of his last nine appearances against NL Central opponents.

Chicago Cubs Player Prop Facts

Seiya Suzuki has hit a home run in two of the Cubs’ last three road games against the Reds.
Nico Hoerner has recorded at least one hit in each of the Cubs’ last nine games against NL opponents.
Seiya Suzuki has recorded at least one Double in each of the Cubs’ last four games at Great American Ball Park.

Cubs vs Reds Prediction 

Chicago comes into this matchup looking for their fifth straight victory and they clinched a playoff berth, so vibes are high with the Cubs. Chicago is 42-35 on the road this year, while Cincinnati is 40-34 at home. The Reds are trying to stay in the wild card race and they are starting Greene, who has allowed 5, 1, 1, 3, and 3 earned runs in his last five starts. The Cubs are going with Rea, who has allowed 3, 1, 3, and 6 earned runs in his last four. The Reds have been very inconsistent recently, but I like them to win here.