Cubs vs Brewers Prediction 10/11/2025 Today’s MLB Picks

In this article we will formulate a Cubs vs Brewers prediction for this MLB game on Saturday, October 11th at American Family Field in Milwaukee, Wisconsin. Let’s take a look at the prediction for this MLB Divisional Series matchup. 

Chicago Cubs Betting Preview

The Chicago Cubs are tied 2-2 in this series after they won game four by a score of 6-0 on Thursday. Chicago scored three runs in the first inning and never looked back in the easy win. The Cubs recorded 10 hits in the game and they were led by Happ, who went 1-5 with one home run and three RBIs in the win. Chicago started Boyd, who allowed two hits and zero earned runs over 4.2 innings, while Palencia picked up the win in relief. 

Prior to this series, the Cubs won two out of three against the Padres in the Wild Card round and swept the Cardinals to finish the regular season. Chicago has won seven of their last ten games and they finished second in the NL Central standings. The Chicago pitching staff has a 2.95 ERA with a 1.16 WHIP and a .230 opponent batting average, while their offense has scored 22 runs with a .234 batting average and a .303 on base percentage this postseason. Michael Busch has led Chicago with four home runs and four RBIs, while Seiya Suzuki has added two home runs and four RBIs in the playoffs. The projected starting pitcher for Chicago is TBD. 

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are tied 2-2 in this series after they lost games three and four on the road. In their game four loss, Milwaukee fell behind early, but did have a few chances to get back into the game, before squandering them and getting shutout. The Brewers recorded three hits and they committed one error in the game, while they were led by Chourio, Vaughn, and Frelick, who all had one hit in the loss. Milwaukee started Peralta, who allowed three hits and three earned runs over 4.0 innings for the loss, while Gasser allowed two earned runs in relief. 

Prior to this series, the Brewers had a bye in the Wild Card round, but finished the regular season by losing two out of three against the Reds and Padres. Milwaukee has lost seven of their last eleven games and they finished first in the NL Central standings. The Milwaukee pitching staff had a 3.58 ERA with a 1.23 WHIP and a .230 opponent batting average, while the offense scored 806 runs with a .258 batting average and a .332 on base percentage in the regular season. Christian Yelich led Milwaukee with 29 home runs and 103 RBIs, while William Contreras added 17 home runs and 76 RBIs this year. The projected starting pitcher for Milwaukee is TBD. 

Why the Milwaukee Brewers will win

The Cubs have lost each of their last six road games against teams that held a winning record.
The home team has won seven of the last eight games between the Cubs and Brewers.
The Cubs have failed to cover the run line in eight of their last nine playoff games after not playing the previous day.
The Brewers have covered the run line in five of their last six home games against the Cubs.
The Brewers have led after 3 innings in each of their last three night games against the Cubs at American Family Field.
The Brewers have led after 5 innings in each of their last three home games.

Total Runs Facts

Five of the Brewers’ last six playoff games against NL Central opponents have gone OVER the total runs line.
Four of the Cubs’ last five road playoff games have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cubs’ last five games as underdogs against National League opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last four games between the Cubs and Brewers.

Milwaukee Brewers Player Prop Facts

Andrew Vaughn has hit a home run in three of the Brewers’ last five games against the Cubs at American Family Field.
Brice Turang has recorded a Double in three of the Brewers’ last four games at American Family Field.
Andrew Vaughn has recorded at least one hit in each of his last nine home appearances against the Cubs.

Chicago Cubs Player Prop Facts

Seiya Suzuki has hit a home run in four of the Cubs’ last seven games against NL Central opponents.
Nico Hoerner has recorded at least one hit in each of the Cubs’ last eight games against NL opponents.
Kyle Tucker ranks 7th amongst qualified players for On Base Percentage (.377) this season.

Matchup/League Facts

The Brewers rank 2nd in the league for ERA this season (3.58).
The Brewers rank 3rd in the league for runs scored this season (806).
The Cubs rank T3rd in the league for steals this season (161).
The Cubs rank T4th in the league for triples this season (29).

Cubs vs Brewers Prediction 

Milwaukee cruised to the win in games one and two at home in this series, but they blew plenty of chances in game three and were blown out in game four on the road. I picked the Brewers to win this series at the start of the Divisional Round and I am sticking with them here. Neither team has announced their pitching plans for this game, but I believe in this Milwaukee team at home, where they were 52-29 in the regular season. I also think the Brewers will likely have the edge in pitching throughout the game, so give me Milwaukee to get the win.